Control Of TGF-beta Superfamily Signalling In Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$443,946.00
Summary
Members of the transforming growth factor ? (TGF-?) family of proteins play crucial roles in adult tissue homeostasis. In recent years a new paradigm has emerged suggesting that inhibition of TGF-? signalling could be an effective strategy for restoring homeostasis in disease-affected tissues. Dr Harrison’s overall research strategy is based on this concept, and is particularly focussed on developing specific antagonists of individual TGF-? proteins.
Addressing Inequalities In Women's Health: Research, Implementation And Scale Up Of Evidence Based Care To Improve Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$340,038.00
Summary
My women's reproductive health implementation research program addresses gaps in evidence based health care, builds the evidence for implementation and scale-up of effective interventions into policy and practice and drives health care improvement to deliver better health outcomes. The program focuses on i) specific groups who experience disadvantage through location or socio-economic disadvantage or health condition and ii) women at critical life stages (pre-conception and pregnancy)
Mechanisms Of Abnormal Expression Of The IGF2 Gene In Disorders Affectin Foetal Growth
Funder
National Health and Medical Research Council
Funding Amount
$420,872.00
Summary
The IGF2 gene is crucial for foetal growth. Only the copy inherited from the father is active, a phenomenon named parental imprinting. In some children with foetal overgrowth or growth retardation, the deregulation of imprinting of the IGF2 gene during the first days of foetal development will influence subsequent growth and will also have major implications in post-natal and adult life. We will investigate the mechanisms resulting in abnormal imprinting of IGF2 early in development.
Novel Point-of-care Screening And Treatment Interventions To Improve Pregnancy Outcomes And To Prevent Cervical Cancer In High-burden, Low-income Settings
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
I lead newly-funded research grants worth nearly $10 million to conduct novel intervention trials in sexual and reproductive health. These projects build on the extensive collaborations and the robust nationwide network of clinical field sites that I have established in Papua New Guinea during the past five years. My research will lead to improved maternal and neonatal health outcomes, and prevent premature deaths due to cervical cancer, in high-burden, low-income settings worldwide.
Mechanisms Controlling Sympathetic Nerve Activity To The Heart
Funder
National Health and Medical Research Council
Funding Amount
$101,220.00
Summary
In heart failure there is a large increase in sympathetic nerve activity to the heart and the kidney that has detrimental effects which is related to mortality in patients. The areas in the brain causing the increased nerve activity to the heart are unknown. We will investigate the role of two key brain areas in mediating this increase. In addition we will also focus on local mechanisms that are responsible for the increase in noradrenaline spillover.