Does Maladaptive Remodelling Of The Heart And Vasculature In Response To Preterm Birth Lead To Long-term Cardiovascular Risk?
Funder
National Health and Medical Research Council
Funding Amount
$535,086.00
Summary
Being born prematurely is linked to the development of high blood pressure (a major risk factor for cardiovascular disease) later in life. In this project we will examine whether injury to the cells lining the cardiovascular system and/or structural changes in the wall of the arteries and the heart, as a result of being born early, lead to an elevation in blood pressure and heart dysfunction in adulthood.
An Exploration Of Cerebral Palsy Aetiology: Assisted Reproductive Technology And Congenital Anomalies
Funder
National Health and Medical Research Council
Funding Amount
$89,420.00
Summary
Cerebral palsy (CP) is the most common physical disability of childhood, describing a group of permanent disorders of movement caused by damage to the developing brain. The causes of CP are poorly understood for most people. This study will explore and quantify the impact of two known risk factors on CP: assisted reproductive technology and congenital anomalies. When these causes of CP are better understood, possibilities for prevention of this disability can be sought.
Does Adenotonsillectomy Change Vascular Function In Children With Sleep Breathing Disorders?
Funder
National Health and Medical Research Council
Funding Amount
$522,105.00
Summary
Sleep breathing disorders affect 10% of all children and when severe, obstruction in the upper airways causes serious deficits in growth, development, brain function and heart health. But even mild snoring (without obstruction) may also cause poor health in the arteries that supply blood to the brain and heart, as well as the smaller arteries in the arms and legs. In both adults and children with conditions like diabetes and obesity, poor blood vessel health has been shown to greatly increase th ....Sleep breathing disorders affect 10% of all children and when severe, obstruction in the upper airways causes serious deficits in growth, development, brain function and heart health. But even mild snoring (without obstruction) may also cause poor health in the arteries that supply blood to the brain and heart, as well as the smaller arteries in the arms and legs. In both adults and children with conditions like diabetes and obesity, poor blood vessel health has been shown to greatly increase the future risk of heart attacks, angina and strokes. Children with severe sleep breathing disorders (such as sleep apnoea syndrome) are currently treated by removal of the tonsils and adenoids, which typically resolves snoring and improves sleep, but it is not yet known whether there are any benefits for blood vessel health. The earliest signs of blood vessel disease in children are abnormal function of the lining of the blood vessels (endothelial dysfunction) and thickening of the lining of blood vessels (intima media thickness). They precede the adult diseases of atherosclerosis - which causes heart attacks and strokes, and diabetic kidney and eye disease. These changes can be measured accurately and non-invasively using ultrasound imaging of arteries in the neck and arm. Our primary aim is to assess whether changes in blood vessel health occur in children with sleep breathing disorders across the range of severity, with a secondary aim to measure any changes in cardiovascular control during both sleep (when snoring occurs). Most importantly, by assessing children before and after surgery, we will be able to see for the first time whether treatment of childhood snoring improves blood vessel health. This study may have major implications for the clinical management of snoring children, who may require treatment at an earlier age to prevent poor blood vessel health and an increased risk of cardiovascular diseases later in life.Read moreRead less
Improving the quality of life of children born very premature. This research program is in line with the national research priority to promote good health and well being, and more specifically to provide a healthy start to life for high-risk infants. This research program is attempting to improve the quality of life of infants born very preterm by improving our understanding of the nature of the problems faced by these high-risk children. This knowledge will inform future preventative care and ....Improving the quality of life of children born very premature. This research program is in line with the national research priority to promote good health and well being, and more specifically to provide a healthy start to life for high-risk infants. This research program is attempting to improve the quality of life of infants born very preterm by improving our understanding of the nature of the problems faced by these high-risk children. This knowledge will inform future preventative care and early intervention strategies. More directly, this research program incorporates a series of randomised controlled trials which are all attempting to improve the health and well being of these vulnerable infants.Read moreRead less
Cumulative Harm: Reducing child abuse through improved decision-making. In 2005/06 56,000 cases of child abuse were substantiated in Australia, and this figure is rising exponentially. Disillusionment is growing with an incident based approach to children's safety which fails to either acknowledge or intervene effectively in the cumulative effects of harm to the child's development and well-being. This project uses the leverage of new legislation to re-focus on an earlier intervention with vulne ....Cumulative Harm: Reducing child abuse through improved decision-making. In 2005/06 56,000 cases of child abuse were substantiated in Australia, and this figure is rising exponentially. Disillusionment is growing with an incident based approach to children's safety which fails to either acknowledge or intervene effectively in the cumulative effects of harm to the child's development and well-being. This project uses the leverage of new legislation to re-focus on an earlier intervention with vulnerable children at risk of cumulative harm within a hospital setting. An interdisciplinary lens is bought to the development of new knowledge to provide a better and healthier start to life for this group of children.Read moreRead less
Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in thei ....Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in their mental health and significant cost savings to the community.Read moreRead less
Optimising bubble continuous positive airway pressure (CPAP) for preterm infants. Synchrotron imaging will be used to see how the lungs of newborns are aerated and move when they are supported by continuous positive airway pressure (CPAP) breathing support. This project will provide fundamental biological information that will contribute to refinement of devices to support breathing in babies.