Size matters, but at what cost? Role of male sex hormones in the placenta. This project aims to understand molecular pathways regulated by male sex hormones in the placenta that may contribute to sex-specific fetal growth and survival outcomes in response to reduced oxygen and/or glucose. Through this project, we expect to generate new knowledge of the mechanisms that drive sex-specific placental molecular function using interdisciplinary approaches. The application of this advanced understandin ....Size matters, but at what cost? Role of male sex hormones in the placenta. This project aims to understand molecular pathways regulated by male sex hormones in the placenta that may contribute to sex-specific fetal growth and survival outcomes in response to reduced oxygen and/or glucose. Through this project, we expect to generate new knowledge of the mechanisms that drive sex-specific placental molecular function using interdisciplinary approaches. The application of this advanced understanding of the sex-specific regulation of placental molecular function and fetal growth may be targeted in future studies to improve fetal growth outcomes in placental mammals such as livestock, domestic pets, and humans.Read moreRead less
Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide ....Targeting TGF-beta proteins to control animal reproduction. This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide a non-surgical method of contraception in companion/feral species, which should address the large unmet need for fertility control in these animals.
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