Mechanisms of infertility induced in mice by vaccination with murine zona pellucida 3. This research investigates the means by which a novel immunocontraceptive vaccine induces an infertile state in female mice. The vaccine stimulates an autoimmune condition which resembles certain naturally occurring ovarian diseases. By investigating how ovarian cellular interactions are maintained in normal ovaries and disrupted by the immunocontraceptive vaccine, we will learn a great deal about ovarian fu ....Mechanisms of infertility induced in mice by vaccination with murine zona pellucida 3. This research investigates the means by which a novel immunocontraceptive vaccine induces an infertile state in female mice. The vaccine stimulates an autoimmune condition which resembles certain naturally occurring ovarian diseases. By investigating how ovarian cellular interactions are maintained in normal ovaries and disrupted by the immunocontraceptive vaccine, we will learn a great deal about ovarian function in health and disease. Ultimately this information will be applied to improving the reproductive health of women.
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