Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to matu ....Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to mature cow oocytes in vitro by altering the chemical composition of maturation medium, thus improving the efficiency of laboratory embryo production and related technologies.Read moreRead less
Chemical inhibition: a new approach to investigate the role of a key protease, CtHtrA, from Chlamydia trachomatis. Infertility in women frequently results from infection with Chlamydia trachomatis. This project will develop an inhibitor compound against a important protein from this bacteria. This will establish a new scientific approach to study Chlamydia trachomatis. This project will also contribute to the development of new treatments for infertility.
Cumulative Harm: Reducing child abuse through improved decision-making. In 2005/06 56,000 cases of child abuse were substantiated in Australia, and this figure is rising exponentially. Disillusionment is growing with an incident based approach to children's safety which fails to either acknowledge or intervene effectively in the cumulative effects of harm to the child's development and well-being. This project uses the leverage of new legislation to re-focus on an earlier intervention with vulne ....Cumulative Harm: Reducing child abuse through improved decision-making. In 2005/06 56,000 cases of child abuse were substantiated in Australia, and this figure is rising exponentially. Disillusionment is growing with an incident based approach to children's safety which fails to either acknowledge or intervene effectively in the cumulative effects of harm to the child's development and well-being. This project uses the leverage of new legislation to re-focus on an earlier intervention with vulnerable children at risk of cumulative harm within a hospital setting. An interdisciplinary lens is bought to the development of new knowledge to provide a better and healthier start to life for this group of children.Read moreRead less
Pioneering seed solutions for the industrial hemp industry. This project aims to develop the next generation of elite industrial hemp cultivars, grown for their seed with high protein and oil contents, that are drought resistant and make minimal THC, teamed with research into their feminisation to provide a safer and better method of producing premium female seed to supply to growers. Project outcomes will include increased fundamental knowledge of drought tolerance, cannabinoid biosynthesis and ....Pioneering seed solutions for the industrial hemp industry. This project aims to develop the next generation of elite industrial hemp cultivars, grown for their seed with high protein and oil contents, that are drought resistant and make minimal THC, teamed with research into their feminisation to provide a safer and better method of producing premium female seed to supply to growers. Project outcomes will include increased fundamental knowledge of drought tolerance, cannabinoid biosynthesis and the feminisation process, converted to practical ways to manipulate these important agronomic traits. This will derisk the industrial hemp industry, encouraging increased cultivation of a nutritionally and economically valuable crop in Australia and create valuable intellectual property applicable globally.Read moreRead less
Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in thei ....Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in their mental health and significant cost savings to the community.Read moreRead less
Predicting Perfect Partners: climate resilient seed production technology . This project aims to increase productivity and profitability of the Australian sorghum industry in the face of risks imposed by an increasingly variable climate. This project expects to generate new knowledge of processes limiting hybrid seed production and translate this world-class research into tools and services that can be used by seed companies to improve its efficiency and reliability. The intended outcome will in ....Predicting Perfect Partners: climate resilient seed production technology . This project aims to increase productivity and profitability of the Australian sorghum industry in the face of risks imposed by an increasingly variable climate. This project expects to generate new knowledge of processes limiting hybrid seed production and translate this world-class research into tools and services that can be used by seed companies to improve its efficiency and reliability. The intended outcome will increase the security and sustainability of farming by minimising the risk of climate-induced seed shortages, maintaining Australia’s leadership in agricultural technology development. The expected benefits support profitable and productive businesses, providing Australian agriculture with a competitive, sustainable edge.Read moreRead less
Age at first birth, mode of conception and adjustment to parenthood. The trend to delayed childbearing is well-established, multiply determined and unlikely to change in the short term. This study will provide contemporary Australian evidence on the experience of becoming a parent at different ages, naturally and through assisted conception, for Australian men and women. Both risk and protective factors for older first-time parents will be identified, thus informing policy and services that can ....Age at first birth, mode of conception and adjustment to parenthood. The trend to delayed childbearing is well-established, multiply determined and unlikely to change in the short term. This study will provide contemporary Australian evidence on the experience of becoming a parent at different ages, naturally and through assisted conception, for Australian men and women. Both risk and protective factors for older first-time parents will be identified, thus informing policy and services that can better support Australian families with planning and rearing children. A key outcome will be a Parenting Decision-Aid to provide evidence-based reader-friendly information about the positives and negatives of first-time parenthood at different ages.Read moreRead less
Development of a non-invasive diagnostic test of Embryo Viability. A successful outcome will:
. improve the cost effectiveness of assisted reproductive technologies resulting in reduced health care costs and allowing greater use of ART in animal production
. by greater cost-effectiveness, facilitate greater access to these advanced technologies in less well developed economies
. build the national capacity in development and validation of biotech diagnostics
. build collaborative relationsh ....Development of a non-invasive diagnostic test of Embryo Viability. A successful outcome will:
. improve the cost effectiveness of assisted reproductive technologies resulting in reduced health care costs and allowing greater use of ART in animal production
. by greater cost-effectiveness, facilitate greater access to these advanced technologies in less well developed economies
. build the national capacity in development and validation of biotech diagnostics
. build collaborative relationship between the CI, University of Sydney and a leading industry partner (Cook Australia)
. lead to significant new fundamental knowledge in embryology that will be of major International significance
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Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health ser ....Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health service delivered to the Australian public. This project aims to develop better tests for application in prenatal diagnostics including non-invasive testing of fetal cells from maternal circulation or cervical samples at 6-13 weeks gestation, IVF and cancer diagnostics.Read moreRead less
Developing technologies that support the genetic modification of rats. Rats and the mouse play critical roles in medical research. Until recently, the targeted genetic modification of a mammal was limited to the mouse. This was due to a technology that was unique to the mouse: embryonic stem (ES) cells. These cells have not been isolated from any other species. The recent development of animal cloning allows for an alternate strategy for targeting genes. We propose to develop cloning strate ....Developing technologies that support the genetic modification of rats. Rats and the mouse play critical roles in medical research. Until recently, the targeted genetic modification of a mammal was limited to the mouse. This was due to a technology that was unique to the mouse: embryonic stem (ES) cells. These cells have not been isolated from any other species. The recent development of animal cloning allows for an alternate strategy for targeting genes. We propose to develop cloning strategies in the rat that supports the genetic modification of this animal. The development of this technology will bring considerable benefits to the areas of physiological research and drug design.Read moreRead less