Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to matu ....Improving the efficiency of bovine oocyte maturation in vitro. For the dairy and beef industries, the hundreds of eggs (oocytes) in a high value cow's ovary that fail to produce a pregnancy are a wasted genetic resource. A key technology to unlocking this resource is in vitro maturation of oocytes, but the process is inefficient. One possible cause is that the current approaches to maturing oocytes in vitro do not adequately mimic the natural process in vivo. We will design new systems to mature cow oocytes in vitro by altering the chemical composition of maturation medium, thus improving the efficiency of laboratory embryo production and related technologies.Read moreRead less
Pioneering seed solutions for the industrial hemp industry. This project aims to develop the next generation of elite industrial hemp cultivars, grown for their seed with high protein and oil contents, that are drought resistant and make minimal THC, teamed with research into their feminisation to provide a safer and better method of producing premium female seed to supply to growers. Project outcomes will include increased fundamental knowledge of drought tolerance, cannabinoid biosynthesis and ....Pioneering seed solutions for the industrial hemp industry. This project aims to develop the next generation of elite industrial hemp cultivars, grown for their seed with high protein and oil contents, that are drought resistant and make minimal THC, teamed with research into their feminisation to provide a safer and better method of producing premium female seed to supply to growers. Project outcomes will include increased fundamental knowledge of drought tolerance, cannabinoid biosynthesis and the feminisation process, converted to practical ways to manipulate these important agronomic traits. This will derisk the industrial hemp industry, encouraging increased cultivation of a nutritionally and economically valuable crop in Australia and create valuable intellectual property applicable globally.Read moreRead less
Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health ser ....Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health service delivered to the Australian public. This project aims to develop better tests for application in prenatal diagnostics including non-invasive testing of fetal cells from maternal circulation or cervical samples at 6-13 weeks gestation, IVF and cancer diagnostics.Read moreRead less
Nanosampling sensors for real-time embryo monitoring. The health potential of every individual is established early in life, during the period when the oocytes mature and embryos are formed. This project will develop a photonic sensing platform capable of monitoring embryos as they develop, which will lead to new insight into the earliest stages of life and improved assisted reproduction technologies.
Breeder-ready genetic tools for sustaining wheat yields under heat stress. Yield losses in wheat due to heat stress are increasing with climate change, driving an urgent need for new heat-tolerant varieties; however, few resources for heat tolerance are available for use in breeding. This research aims to use comprehensive genetic and agronomic approaches to provide breeders with the tools and evidence to select WtmsDW, a newly discovered genetic region that protects pollen fertility and sustain ....Breeder-ready genetic tools for sustaining wheat yields under heat stress. Yield losses in wheat due to heat stress are increasing with climate change, driving an urgent need for new heat-tolerant varieties; however, few resources for heat tolerance are available for use in breeding. This research aims to use comprehensive genetic and agronomic approaches to provide breeders with the tools and evidence to select WtmsDW, a newly discovered genetic region that protects pollen fertility and sustains grain yield under heat stress. These tools are expected to significantly boost productivity for the $9.8B Australian wheat industry, benefitting rural communities and industry partners and supporting food security, both directly and through longer-term extension of novel heat tolerance mechanisms to other crop species.Read moreRead less