Health And Fertility Of Young Men Conceived Using Intra-cytoplasmic Sperm Injection
Funder
National Health and Medical Research Council
Funding Amount
$362,570.00
Summary
The injection of a single sperm into the egg (ICSI) has been the main IVF treatment for men with poor sperm quality since 1993 but is now often used for other types of infertility. Concern has been raised about the health of the children. We will approach >800 parents and their adult sons conceived using ICSI and will assess his general health and development, and fertility. This work will improve patient counselling and practice guidelines, and direct research into the safety of ICSI.
Role Of The Anaphase-Promoting Complex Activator Cdh1 In Oocyte Maturation And Meiotic Aneuploidy
Funder
National Health and Medical Research Council
Funding Amount
$526,878.00
Summary
Eggs containing an incorrect number of chromosomes are described as aneuploid. This project sets out to examine the molecular causes of aneuploidy and why it increases with female age. We focus on the protective role of the protein Cdh1 in this process. The outcome would be to better understand the origins of aneuploidy so as to find methods of decreasing it as women age. This is highly significant given aneuploidy is the leading cause of early embryo loss and produces Down Syndrome babies.
Understanding an important aspect of current-day family dynamics: the institution of repartnering in Australia. Families are at the core of Australia's social fabric. Understanding their dynamics assists in developing good policies and mechanisms to support them. Repartnering is an important aspect of current-day family dynamics. Yet we know relatively little about how these partnerships operate. This project will illuminate the patterns and issues central to repartnering and provide a significa ....Understanding an important aspect of current-day family dynamics: the institution of repartnering in Australia. Families are at the core of Australia's social fabric. Understanding their dynamics assists in developing good policies and mechanisms to support them. Repartnering is an important aspect of current-day family dynamics. Yet we know relatively little about how these partnerships operate. This project will illuminate the patterns and issues central to repartnering and provide a significant contribution to social research. Results from this study will equip policy makers with appropriate knowledge to develop policies aimed at assisting families. The findings will contribute to growing international knowledge on family dynamics in repartnered relationships, as well as strengthen Australia's social and economic fabric through stronger families.Read moreRead less
Do Australian parents want both a son and a daughter? From the late 1990s, policy makers became more aware of the importance of fertility in influencing population age structure and growth rates in Australia. The proposed project will augment our understanding of fertility dynamics both current, and over high and low fertility regimes. It will also highlight an important factor in fertility decision-making. There is considerable speculation on the impact of shifting gender-role attitudes on sex ....Do Australian parents want both a son and a daughter? From the late 1990s, policy makers became more aware of the importance of fertility in influencing population age structure and growth rates in Australia. The proposed project will augment our understanding of fertility dynamics both current, and over high and low fertility regimes. It will also highlight an important factor in fertility decision-making. There is considerable speculation on the impact of shifting gender-role attitudes on sex preference, but evidence supporting this is mixed. By developing a deeper understanding of the factors influencing progression to having more children we will be better able to predict fertility trends and provide support to Australian parents. Read moreRead less
Family Formation and Fertility Decline in Nineteenth-Century Tasmania. The fertility decline which began across the industrialised world in the late nineteenth century greatly impacted the demographic, economic and social milieux of the twentieth century and beyond. Using family reconstitution techniques and a wide range of data, this project will explore the mechanisms by which fertility decline was achieved in nineteenth-century Tasmania and the broader societal influences that brought these m ....Family Formation and Fertility Decline in Nineteenth-Century Tasmania. The fertility decline which began across the industrialised world in the late nineteenth century greatly impacted the demographic, economic and social milieux of the twentieth century and beyond. Using family reconstitution techniques and a wide range of data, this project will explore the mechanisms by which fertility decline was achieved in nineteenth-century Tasmania and the broader societal influences that brought these mechanisms into play. The results will advance our understanding of Australia's evolution over the nineteenth century and into the twentieth century. The research will result in three journal articles, a single-authored monograph and wide public dissemination.Read moreRead less
Childbearing within cohabiting unions in Australia: trends, explanations and comparison. This project will explore the trends and determinants of childbearing within cohabitation in Australia. The project will contribute to our understanding of modern family dynamics and change. By comparison with other countries we will learn more about the policy settings that assist and support couples to realise their family formation plans.
ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology indust ....ARC Centre of Excellence in Biotechnology and Development. The Centre will create a multidisciplinary research team focusing on the molecular mechanisms that drive the specification and differentiation of male germ cells. This research will improve our fundamental understanding of how complex regulatory networks control the expression of a complex phenotype, the spermatozoon. It will also create a platform of knowledge from which we can stimulate the growth of the Australian Biotechnology industry, the protection of the Australian Environment and the well-being of the Australian people. Key issues for this Centre include testicular cancer, male infertility, contraception, pest animal control, environmental impacts on human health and gene pharming.Read moreRead less
Epidemics, mortality and longevity in Tasmania, 1838-1930. This project will investigate areas of contemporary importance that can only be explored using historic-demographic data. National benefits include (1) gaining a better understanding of how epidemics spread through families and communities, and possible mortality and case-fatality rates, to assist in preparation for future epidemics; (2) improved accuracy in projecting older-age mortality and population ageing in Australia and other coun ....Epidemics, mortality and longevity in Tasmania, 1838-1930. This project will investigate areas of contemporary importance that can only be explored using historic-demographic data. National benefits include (1) gaining a better understanding of how epidemics spread through families and communities, and possible mortality and case-fatality rates, to assist in preparation for future epidemics; (2) improved accuracy in projecting older-age mortality and population ageing in Australia and other countries; and (3) more precise estimates of women's capacity to naturally conceive and carry to term by characteristics such as her age, her partner's age, and her number of previous births. The project will also result in augmentation of a unique publicly available dataset.Read moreRead less
Inequality in first family formation in contemporary Australia. The timing and context of Australians' entry into parenthood differs across the socio-economic spectrum. This project investigates the socio-economic disparities in entering parenthood, particularly focusing on education and employment differentials as well as socio-demographic factors such as ethnic and religious background, and experience of family dissolution. Using longitudinal panel data, this project aims to: determine the soc ....Inequality in first family formation in contemporary Australia. The timing and context of Australians' entry into parenthood differs across the socio-economic spectrum. This project investigates the socio-economic disparities in entering parenthood, particularly focusing on education and employment differentials as well as socio-demographic factors such as ethnic and religious background, and experience of family dissolution. Using longitudinal panel data, this project aims to: determine the socio-economic and demographic differentials of inequality in first family formation in Australia; discover how inequality in first family formation has changed since the middle of the 20th Century; and, assess how family-policy regime mediates or exacerbates this inequality.Read moreRead less
Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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