Primary central nervous system (CNS) tumours, arising in the brain and spinal cord, are the leading cause of cancer-related deaths in children less than 15 years of age. Medulloblastomas and other primitive neuroectodermal tumours (PNETs) are the most common form of primary childhood brain tumours, accounting for 25-30% of cases. Despite notable recent advances in our understanding of the molecular genetic basis of malignancies, the pathogenesis of CNS PNETs remains obscure. To address this prob ....Primary central nervous system (CNS) tumours, arising in the brain and spinal cord, are the leading cause of cancer-related deaths in children less than 15 years of age. Medulloblastomas and other primitive neuroectodermal tumours (PNETs) are the most common form of primary childhood brain tumours, accounting for 25-30% of cases. Despite notable recent advances in our understanding of the molecular genetic basis of malignancies, the pathogenesis of CNS PNETs remains obscure. To address this problem, we propose to apply a novel combinatorial approach for the identification of PNET tumour suppressor genes utilising both representational difference analysis (RDA) and microarray expression profiling. Data from this study will help to elucidate the molecular pathways that are compromised in the initiation and growth of PNETs. This information will have direct implications for the development of improved diagnostic and prognostic indicators necessary for the design of more effective therapeutic strategies for the treatment of PNET patients.Read moreRead less
HARMONIC ANALYSIS AND BOUNDARY VALUE PROBLEMS FOR ELLIPTIC SYSTEMS. It is of the utmost necessity for Australia to develop the theoretical
expertise needed in the current era. The type of mathematics under
investigation here is closely allied to that needed in much of the
current boom in communication technology and medical research. The
training which would be provided to the research associates is
considerable, and would flow on to produce the expertise needed to
keep the coming gen ....HARMONIC ANALYSIS AND BOUNDARY VALUE PROBLEMS FOR ELLIPTIC SYSTEMS. It is of the utmost necessity for Australia to develop the theoretical
expertise needed in the current era. The type of mathematics under
investigation here is closely allied to that needed in much of the
current boom in communication technology and medical research. The
training which would be provided to the research associates is
considerable, and would flow on to produce the expertise needed to
keep the coming generation involved in modern technological development. I will maintain my large collaborative effort with
leading mathematicians from the US, France and other countries, thus
helping to keep Australia at the forefront of a significant field of
research.Read moreRead less
HARMONIC ANALYSIS OF ELLIPTIC SYSTEMS ON RIEMANNIAN MANIFOLDS. It is of the utmost necessity for Australia to develop the theoretical expertise needed in the current era. The type of mathematics under investigation here is closely allied to that needed in much of the current boom in communication technology and medical research. The training which would be provided to the research associates is considerable, and would flow on to produce the expertise needed to keep the coming generation invol ....HARMONIC ANALYSIS OF ELLIPTIC SYSTEMS ON RIEMANNIAN MANIFOLDS. It is of the utmost necessity for Australia to develop the theoretical expertise needed in the current era. The type of mathematics under investigation here is closely allied to that needed in much of the current boom in communication technology and medical research. The training which would be provided to the research associates is considerable, and would flow on to produce the expertise needed to keep the coming generation involved in modern technological development. I will maintain my active collaborative effort with leading mathematicians from the US, France and other countries, thus helping to keep Australia at the forefront of a significant field of research.Read moreRead less
Propagation of singularities for the Schrodinger equation. The time-dependent Schrodinger equation governs the evolution of quantum particles. In this project we aim to use new techniques from mathematical scattering theory to analyse solutions of the Schrodinger equation and obtain sharp bounds on their singularities. Controlling such singularities will allow us to deduce quantitative bounds on the number of eigenvalues in certain situations, and provide new techniques for studying nonlinear Sc ....Propagation of singularities for the Schrodinger equation. The time-dependent Schrodinger equation governs the evolution of quantum particles. In this project we aim to use new techniques from mathematical scattering theory to analyse solutions of the Schrodinger equation and obtain sharp bounds on their singularities. Controlling such singularities will allow us to deduce quantitative bounds on the number of eigenvalues in certain situations, and provide new techniques for studying nonlinear Schrodinger equations. Read moreRead less
HARMONIC ANALYSIS, BOUNDARY VALUE PROBLEMS, AND MAXWELL'S EQUATIONS IN LIPSCHITZ DOMAINS. Boundary value problems for partial differential equations arise naturally when physical problems are expressed in mathematical terms. This project concerns the systematic development of the harmonic analysis of partial differential operators, and of the corresponding boundary integrals in order to solve such problems on irregular regions. Particular emphasis is given to studying the behaviour of electrom ....HARMONIC ANALYSIS, BOUNDARY VALUE PROBLEMS, AND MAXWELL'S EQUATIONS IN LIPSCHITZ DOMAINS. Boundary value problems for partial differential equations arise naturally when physical problems are expressed in mathematical terms. This project concerns the systematic development of the harmonic analysis of partial differential operators, and of the corresponding boundary integrals in order to solve such problems on irregular regions. Particular emphasis is given to studying the behaviour of electromagnetic waves both inside and outside irregularly shaped surfaces, and their propagation through it.Read moreRead less
Functional and harmonic analysis of function spaces: synthesis, development and applications. Recent advances in mathematics are on the borderlines of its branches. This interdisciplinary project develops and binds the research areas attracting growing interest of prominent mathematicians during the last 30 years because of not only its theoretical value, but also its ties with the key equations describing a multitude of physical phenomena and the theoretical foundation of numerical methods. Th ....Functional and harmonic analysis of function spaces: synthesis, development and applications. Recent advances in mathematics are on the borderlines of its branches. This interdisciplinary project develops and binds the research areas attracting growing interest of prominent mathematicians during the last 30 years because of not only its theoretical value, but also its ties with the key equations describing a multitude of physical phenomena and the theoretical foundation of numerical methods. The Euler, Helmholtz, Lamb, Navier-Stokes and acoustic equations, studied in terms of function spaces, govern incompressible viscous fluid flows and wave propagations. Contributing to both pure mathematics and, particularly, Short-Term Tsunami Prediction, the project will enhance Australia's research reputation.Read moreRead less
Quantum chaos and scattering theory. The project will involve mathematical research of the highest international standard, as well as research training of postgraduate students and postdoctoral researchers, in a very active and far-reaching field. Progress in this field will have implications in areas ranging from engineering (e.g. nanotechnology, quantum computing) and mathematical analysis (e.g. theory of partial differential equations) through to number theory.
The Spectral Theory and Harmonic Analysis of Geometric Differential Operators. The project will involve mathematical research of the highest international standard in two very active and far-reaching field of mathematics: quantum chaos, and harmonic analysis. Progress in these fields will have implications in areas such as communications technology (e.g. image compression), quantum theory, and mathematical analysis (e.g. partial differential equations).
Computational Schemes for Initial-Boundary Value Problems. Many physical phenomena can be modelled as initial-boundary value problems described by partial differential equations. Simulations of such models require efficient and robust computational algorithms. The main aim of this project is to propose numerical algorithms for two dimensional spatial problems and three dimensional time-space models. A major focus of the project is to investigate methods that require about half the computation ....Computational Schemes for Initial-Boundary Value Problems. Many physical phenomena can be modelled as initial-boundary value problems described by partial differential equations. Simulations of such models require efficient and robust computational algorithms. The main aim of this project is to propose numerical algorithms for two dimensional spatial problems and three dimensional time-space models. A major focus of the project is to investigate methods that require about half the computational resources over celebrated schemes for solving boundary value problems.Read moreRead less