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Escape And Reversion Of Critical Immune Responses: Insights Into Effective Immunity To HIV
Funder
National Health and Medical Research Council
Funding Amount
$372,446.00
Summary
The HIV pandemic is a global emergency. The overall goal of this grant proposal is to elucidate the requirements for protective immunity to HIV. Although immune responses have some effect on HIV replication, the virus mutates and evolves to escape immune pressure. However, each mutation away from wild-type virus likely results in at least some impairment in the ability of the virus to replicate. Where efficient immune responses target regions of the virus that are critical to virus replication, ....The HIV pandemic is a global emergency. The overall goal of this grant proposal is to elucidate the requirements for protective immunity to HIV. Although immune responses have some effect on HIV replication, the virus mutates and evolves to escape immune pressure. However, each mutation away from wild-type virus likely results in at least some impairment in the ability of the virus to replicate. Where efficient immune responses target regions of the virus that are critical to virus replication, escape mutations may result in viral variants incapable of causing disease. Resulting from an exciting collaboration between HIV and theoretical biologists, we have recently identified techniques to calculate the effectiveness of immunity and the cost of subsequent immune escape variants. We will use and expand these techniques to identify immune responses that result in the most effective control of viral replication. These studies will lead to ways to improve HIV vaccines and thereby prevent HIV.Read moreRead less
IMproving Physical ACtivity With Treadmill Training Following Stroke: The Stroke-IMPACT Trial
Funder
National Health and Medical Research Council
Funding Amount
$736,065.00
Summary
Stroke is a leading cause of disability amongst Australians. After stroke, activity levels are low, with few people able to exercise at an intensity which will reduce the risk of future cardiovascular events. This project examines the effectiveness of combining a high intensity treadmill training program with a self management approach to improve activity levels, mobility, cardiovascular risk profile in stroke survivors, increasing their independence and reducing the burden of care.
There’s recent evidence that children get leaner and fitter during the school term, but become fatter and less fit over the summer holidays. This may be because of differences in activity and diet: on holidays, children may eat more, be less active and have more screen time. We propose to track the time use, diet, fitness and fatness of 9-11 year old children across three school years. If the pattern is confirmed, we should focus more on the home environment, or perhaps encourage summer camps.
Feasibility, Safety, Adherence, And Efficacy For High Intensity Interval Training In A Hospital-Initiated Rehabilitation Program For Heart Disease
Funder
National Health and Medical Research Council
Funding Amount
$75,779.00
Summary
This project aims to investigate if high intensity interval training can be successfully integrated into a hospital-based cardiac rehabilitation program as a practical and safe alternative to the usual care exercise protocol (moderate intensity continuous training). We expect high intensity interval training will be a safe and practical option for appropriate patients, and will offer greater improvements in fitness, exercise adherence, cardiovascular risk factors, and intra-abdominal fat.
A Saturation Screen For Modifiers Of Epigenetic Reprogramming In The Mouse: Phase II
Funder
National Health and Medical Research Council
Funding Amount
$1,374,820.00
Summary
The building of a complex organism, such as a human embryo, is a self-directed process driven by the genetic information inherited from the parents. As the cells differentiate into a diverse array of tissues, the genetic information does not change. What does change is the epigenetic state of the genome in each cell type. We still understand little about this epigenetic reprogramming except that mistakes in the process lead to death and disease. Our work aims to address this lack of knowledge
A Scalable Intervention For Increasing Vigorous Physical Activity Among Older Adolescents: The ‘ Burn To Learn ’ Cluster RCT
Funder
National Health and Medical Research Council
Funding Amount
$636,912.00
Summary
Physical inactivity has been described as a global pandemic and only 15% of Australian adolescents are sufficiently active. The pressure to perform in major school assessments drives many older adolescents to sacrifice physical activity to maximise academic performance. Our team has designed a time-efficient solution to increase physical activity in senior high school students using high intensity interval training which will be evaluated using a cluster randomised controlled trial.
There is increasing evidence that regular physical activity contributes considerably to better physical fitness and good health of individuals and nations. Unfortunately, many individuals in Australia are not regularly active. A sedentary lifestyle is associated with a higher risk of coronary heart disease, obesity, diabetes, osteoporosis and some cancers. Physical activity guidelines encourage participation in at least 30 minutes of moderate-intensity physical activity on most, preferably all, ....There is increasing evidence that regular physical activity contributes considerably to better physical fitness and good health of individuals and nations. Unfortunately, many individuals in Australia are not regularly active. A sedentary lifestyle is associated with a higher risk of coronary heart disease, obesity, diabetes, osteoporosis and some cancers. Physical activity guidelines encourage participation in at least 30 minutes of moderate-intensity physical activity on most, preferably all, days of the week. Walking is one of the most common forms of physical activity undertaken by adults, however there is a relatively poor understanding of the physiological demands of this task. A better understanding of walking for people of different age, gender, size and shape would provide for improvements in the categorisation of intensity of physical activity for use in population measures of physical activity and exercise prescription for individuals who are obese. The aim of the proposed study is to assess the relationship between energy cost of walking and body composition of adults. The main purpose is to consider how people of different age, gender, size and shape manage self-paced walking relative to maximal capacity. The energy cost of walking is an important determinant of a person's functional capacity, physical fitness and health status. The main outcomes of the study: An increased knowledge and understanding of the energy expenditure of self-paced walking relative to maximal aerobic power; More reliable assessment of physical activity status using a variety of commonly employed indirect assessment techniques; A comprehensive understanding of the inter-individual differences in walking characteristics based on age, gender or body fatness; A better understanding of the energy cost of walking and the subsequent promotion of this form of physical activity has potential to impact on the health of Australians, particularly those who are sedentary and overweight or obese.Read moreRead less