The Australian Research Data Commons (ARDC) invites you to participate in a short survey about your
interaction with the ARDC and use of our national research infrastructure and services. The survey will take
approximately 5 minutes and is anonymous. It’s open to anyone who uses our digital research infrastructure
services including Reasearch Link Australia.
We will use the information you provide to improve the national research infrastructure and services we
deliver and to report on user satisfaction to the Australian Government’s National Collaborative Research
Infrastructure Strategy (NCRIS) program.
Please take a few minutes to provide your input. The survey closes COB Friday 29 May 2026.
Complete the 5 min survey now by clicking on the link below.
Cancer cachexia is a devastating disease characterised by skeletal muscle wasting and weakness. It impairs patient quality of life and accounts for >20% of cancer-related deaths. My work aims to identify factors contributing to the development of cancer cachexia. This insight will then enable me to test potential strategies to prevent the wasting seen in cancer patients to improve their quality of life and to reduce mortality.
This proposal aims to examine central mechanisms important in stress related hypertension. My team will focus on the role of tissue plasminogen activator in mediating inhibitory effects of chronic stress on neural plasticity and examine inhibitory dysfunction in GABAergic and nitric oxide pathways that lead to increased sympathetic activity and elevated blood pressure. Importantly, we will investigate the potential of three interventions directed at each as therapies for hypertension.
This study focuses on key endocrine pathways involved in the remodelling of the breast stromal cells into a reactive stromal environment which is more permissive for tumour growth. We have identified key pathways involved in the regulation of estrogen biosynthesis and fibrosis in tumour associated stroma. These studies will lead to the development of novel breast cancer therapies.
Mechanisms Controlling Sympathetic Nerve Activity To The Heart
Funder
National Health and Medical Research Council
Funding Amount
$101,220.00
Summary
In heart failure there is a large increase in sympathetic nerve activity to the heart and the kidney that has detrimental effects which is related to mortality in patients. The areas in the brain causing the increased nerve activity to the heart are unknown. We will investigate the role of two key brain areas in mediating this increase. In addition we will also focus on local mechanisms that are responsible for the increase in noradrenaline spillover.