Cellular Regulation Of Tooth Matrix Deposition And Remineralisation
Funder
National Health and Medical Research Council
Funding Amount
$124,530.00
Summary
Caries is one of the most prevalent of all human diseases. It has a very significant impact on the health budget of a nation apart from its effect on the individual concerned. In recent years there has been a growing recognition that healing or re-mineralisation protocols for the treatment of carious lesions in dentine are possible, rather than just relying on surgical removal of the diseased tissue and placement of restoratives. This project proposes to investigate a strategy for deliberately s ....Caries is one of the most prevalent of all human diseases. It has a very significant impact on the health budget of a nation apart from its effect on the individual concerned. In recent years there has been a growing recognition that healing or re-mineralisation protocols for the treatment of carious lesions in dentine are possible, rather than just relying on surgical removal of the diseased tissue and placement of restoratives. This project proposes to investigate a strategy for deliberately stimulating cellular reparative processes for the treatment of this disease. It is expected that the outcomes from this research will have a major influence on the techniques and materials used to treat this disease. They will potentially have a very broad application from the paediatric to the geriatric sectors of the dental profession.Read moreRead less
Dental caries (tooth decay) is initiated by demineralisation of tooth hard tissue by organic acids produced by dental plaque bacteria from dietary sugars. The disease is a major public health problem and has an estimated economic burden in Australia of over $1 billion p.a. being higher than that for any other dietary-related disease. We have discovered and patented a novel amorphous calcium fluoride phosphate that is stabilised by phosphopeptides from the bovine milk protein casein. These comple ....Dental caries (tooth decay) is initiated by demineralisation of tooth hard tissue by organic acids produced by dental plaque bacteria from dietary sugars. The disease is a major public health problem and has an estimated economic burden in Australia of over $1 billion p.a. being higher than that for any other dietary-related disease. We have discovered and patented a novel amorphous calcium fluoride phosphate that is stabilised by phosphopeptides from the bovine milk protein casein. These complexes, designated CPP-ACFP, have the potential to provide superior clinical efficacy in preventing dental caries and treating and repairing early stages of disease. The aims of this project therefore are (i) to develop topical formulations of CPP-ACFP for application to teeth to repair early stages of decay and (ii) to characterise the three-dimensional structure of the CPP-ACFP complexes. The significance of this work is that a superior and novel treatment for dental caries may be developed as well as providing insight into the structure of organically-stabilised amorphous calcium phosphate and its role in biomineralisation processes.Read moreRead less