Critical Infection: Ecological Solutions To Antibiotic Resistance
Funder
National Health and Medical Research Council
Funding Amount
$561,362.00
Summary
The applicant will apply new types of microbial data and diagnostic tools to early interventions in the critically ill and directly test their impact on clinical outcomes. He will also introduce novel therapies to restore antibiotic susceptibility to enteric bacteria and examine the clinical and microbiological effects of antibiotic decontamination of the critically ill in newly funded project grants. Overlapping research themes all link directly to his clinical and professional roles.
Developing and testing a novel biological reduction cell to remediate heavy metal and acid-containing industrial and mine leachates. Echo Remediation Ltd. has a new reduction cell that uses sulfur and bacteria to remove heavy metals and acidity from mine leachates, but development is now required to make it viable. The project aims to optimise the process using molecular approaches to study the effects of operating conditions on the bacterial communities. As part of the investigation, active iro ....Developing and testing a novel biological reduction cell to remediate heavy metal and acid-containing industrial and mine leachates. Echo Remediation Ltd. has a new reduction cell that uses sulfur and bacteria to remove heavy metals and acidity from mine leachates, but development is now required to make it viable. The project aims to optimise the process using molecular approaches to study the effects of operating conditions on the bacterial communities. As part of the investigation, active iron reducers will be selected and introduced to the cell (in conjunction with chemical amendments) and their colonization monitored. The new technology once developed has the potential to be used at mine sites in Australia and overseas and its employment offers a sustainable, biological "green" approach to mine waste remediation.Read moreRead less
Optimising biodegradation and removal of organic and inorganic pollutants in wastewater using constructed wetlands. The urgency of water recycling is dictated by drying climate and rapid expansion of population in Australia. Constructed wetlands are environmentally-benign way to purify wastewater by removing inorganics and facilitating biodegradation of organic pollutants, thus producing recycled water that can be used in a variety of fit-for-purpose applications. This project will produce a dec ....Optimising biodegradation and removal of organic and inorganic pollutants in wastewater using constructed wetlands. The urgency of water recycling is dictated by drying climate and rapid expansion of population in Australia. Constructed wetlands are environmentally-benign way to purify wastewater by removing inorganics and facilitating biodegradation of organic pollutants, thus producing recycled water that can be used in a variety of fit-for-purpose applications. This project will produce a decision-support system for optimising wetland performance in removing inorganics and biodegrading organic pollutants from wastewater, thus enhancing water recycling and reuse in this drying continent of ours.Read moreRead less
Development And Pre-Clinical Evaluation Of A Silicone Dressing For Scar Remediation
Funder
National Health and Medical Research Council
Funding Amount
$163,577.00
Summary
This research is aimed at exploiting advanced polymers as a new therapy for patients with burn related scars, as well as people who are genetically predisposed to scarring due to abnormal healing. In order to progress to clinical trials, the technology needs to be tested on an animal scar model. Successful outcome of these tests will allow the industry partner, Tissue Therapies, to proceed with a clinical trial, paving the way to a therapeutic product available for scar treatment.
Amelioration strategies to reduce environmental deterioration and agricultural production losses in water repellent regions. Millions of hectares of potentially productive agricultural land in Australia are affected by water-repellency. Water repellency causes non-uniform infiltration of water in soils and promotes surface erosion. Consequently, water repellent soils cannot be satisfactorily used for agricultural production, resulting in production losses of millions of dollars annually. This in ....Amelioration strategies to reduce environmental deterioration and agricultural production losses in water repellent regions. Millions of hectares of potentially productive agricultural land in Australia are affected by water-repellency. Water repellency causes non-uniform infiltration of water in soils and promotes surface erosion. Consequently, water repellent soils cannot be satisfactorily used for agricultural production, resulting in production losses of millions of dollars annually. This investigation is part of a genuine international effort that will develop new procedures to ameliorate water-repellent soils. New and improved mathematical models and decision support tools will also be developed to improve water-repellent land management, reduce environmental risk and minimise agriculture production loss.Read moreRead less
Skill Building Interventions To Address Barriers To Social Inclusion For People With Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$251,715.00
Summary
People with a psychotic illness often experience unemployment, social isolation and difficulty living independently. Social and cognitive (e.g. thinking and memory) skill difficulties contribute to this, however, most psychiatric treatments fail to improve the underlying skill problems. This program of research will measure whether computer-assisted cognitive remediation and social skill training can effectively improve everyday living and social participation in people with a psychotic illness.
Are acidic mine lakes usable as regional water resources? After the de-commissioning of open-cut mines, the voids frequently fill with water. In Australia, hundreds of mine lakes will develop over the next ten years and beyond. When the base mineralogy is pyritic the water can become highly acidic with high concentrations of dissolved metals. These mine lakes frequently exist in regions where water resources are in short supply. This project will investigate possible strategies to remediate such ....Are acidic mine lakes usable as regional water resources? After the de-commissioning of open-cut mines, the voids frequently fill with water. In Australia, hundreds of mine lakes will develop over the next ten years and beyond. When the base mineralogy is pyritic the water can become highly acidic with high concentrations of dissolved metals. These mine lakes frequently exist in regions where water resources are in short supply. This project will investigate possible strategies to remediate such lakes and assess the possibility of using mining lakes as valued water resources in these regions. The primary outcome of the research will be improved management of the lakes for optimal long term water quality.Read moreRead less
Drought and Salinity Tolerance in Metal Hyperaccumulating Plants: A Functional Role for the Metals? A few plant species can ?hyperaccumulate? metal ions to 100-1000 times the concentrations seen in ?normal? plants. Just why these plants have evolved such an extreme response to metalliferous soils remains an enigma. Many of the hyperaccumulators so far described are endemic to xeric environments, or saline soils prone to rapid drying. We hypothesize that the metals might act as osmotica, enha ....Drought and Salinity Tolerance in Metal Hyperaccumulating Plants: A Functional Role for the Metals? A few plant species can ?hyperaccumulate? metal ions to 100-1000 times the concentrations seen in ?normal? plants. Just why these plants have evolved such an extreme response to metalliferous soils remains an enigma. Many of the hyperaccumulators so far described are endemic to xeric environments, or saline soils prone to rapid drying. We hypothesize that the metals might act as osmotica, enhancing plant survival during water stress. This will be tested for Australian native and non-native hyperaccumulator plants. The study will clarify our understanding of the evolutionary significance of hyperaccumulation, and has important applications for extracting metals from contaminated soils.Read moreRead less
Investigation of Australian crop species for the rhizoremediation of residual sulfonyl urea herbicide contaminations in agricultural soils. This research aims to identify an environmentally sustainable and economically viable solution to the problem of residual herbicide contaminations in agricultural soils. The strategy is focused on stimulation of microbial degradation of pesticides in the root zone of crop species (Lupins). Such a strategy will improve crop yields and reduce soil contaminatio ....Investigation of Australian crop species for the rhizoremediation of residual sulfonyl urea herbicide contaminations in agricultural soils. This research aims to identify an environmentally sustainable and economically viable solution to the problem of residual herbicide contaminations in agricultural soils. The strategy is focused on stimulation of microbial degradation of pesticides in the root zone of crop species (Lupins). Such a strategy will improve crop yields and reduce soil contaminations and environmental impacts at minimal cost. Read moreRead less