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Transcriptional And Metabolic Regulation Of Effector And Memory Lymphocyte Differentiation
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
I am an internationally recognized expert in the field of lymphocyte biology. My work has shed light on antibody production, T cell responses and immune pathology. Specifically, I have identified molecular regulators that link antigen recognition, lymphocyte population expansion, cellular metabolism and effector function. My ongoing work focusses on the development and function of several critically important cell types, including tissue resident lymphocytes and regulatory T cells.
Understanding Leukocyte Function In Inflammatory Disease
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
In inflammatory diseases such as rheumatoid arthritis, asthma and lupus, white blood cells accumulate in organs and cause injury. The focus of this project is to understand how white blood cells leave the bloodstream and enter tissues. In particular, this project examines their contribution to inflammatory diseases of the kidney. By understanding this process in greater detail, we may be able to design more specific therapies to combat these conditions.
The human immune system comprises many different types of cells that can detect foreign molecules. My research will lead the way to understanding some of the most abundant, yet least well understood, cells within this system, collectively known as 'unconventional T cells'. This knowledge is essential to optimally and efficiently manipulate the immune system in health and disease.
Defining The Coordination Of Immune Responses To Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$640,210.00
Summary
Understanding how immune responses are coordinated is critical for the design of new therapies and vaccines to target infectious diseases and cancers. This project will utilise advanced imaging combined with novel tools to dissect the complex interactions that occur between immune cells as they are activated and patrol the body to eliminate infectious pathogens.
Delineating Immune Circuits For Innate And Adaptive Immune Protection
Funder
National Health and Medical Research Council
Funding Amount
$876,005.00
Summary
The immune system provides the essential frame-work to protect us against infection, disease and to heal tissues after trauma. This is achieved by a complex but elegant network of different types of white blood cells. Understanding the molecular wiring of these cells will provides fundamental insights to how the body fights pathogen infections and cancer and lays the foundation to therapeutic approaches to vaccination and disease treatments.
My research is aiming to study how the immune system controls viral infections in transplant patients and use this information to bolster their immunity in a test tube, providing protection against a virus the patient is unable to fight after their transplant. We are also trying to develop new strategies to use patient's own blood cells which will be grown in the laboratory and returned to the patient, resulting in a full recovery.
Mapping The Molecular Blueprint For Immune Cell Differentitation
Funder
National Health and Medical Research Council
Funding Amount
$753,300.00
Summary
Killer T cells are white blood cells that are key for helping control virus infections and in the recognition and elimination of cells that have become cancerous. This proposal aims to identify novel molecular mechanisms that control the ability of killer T cells to mediate their antiviral and anti-cancer functions. This will provide molecular targets for possible clinical interventions designed to either promote immunity (vaccination) or limit damage caused by T cell responses that target self
Immune Imprinting By Nanoparticles And Vaccines: New Principles And Translation Into The Clinic
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
Vaccines require adjuvants to be effective. Despite decades of research there is only one adjuvant approved for broad use in humans. Based on our prior findings I will engage new principles in nanotechnology, and deepen understanding of immune imprinting in various organs of the body including the lung, to develop 2nd generation broadly useful nanoadjuvants able to effectively treat cancer and malaria.
I am an cellular immunologist determining the mechanisms by which immunity to foreign organisms is generated, how tolerance to self tissues is maintained, and how the immune system iscriminates between foreign organisms and self.
T cells play a pivotal role in the immune system by recognising viral peptides presented by "HLA" molecules on infected cells through the use of T cell receptors (TCRs). I will investigate the variables that influence T lymphocyte recognition of human herpesvirus infection, including variability in TCR, HLA, and viral genes. Understanding the impact of these variables on how we fight infections will aid in the development of new "intelligent" vaccines and immune-based therapies.