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Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is ....Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is expected to redefine our understanding of the virus-host interactions formed by these important pathogens. By determining the mechanisms of NSV-nucleolus interaction, the project plans to also provide important information for the development of new vaccines/therapeutics for livestock to combat NSVs that target nucleoli.Read moreRead less
Defining domains within Mycoplasma hyopneumoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine. Over 90% of Australian commercial pig production facilities are affected by Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia. This disease causes economic losses in Australia of over $20 million per annum and up to $1 billion per annum in major swine rearing countries worldwide. This project will determine the p ....Defining domains within Mycoplasma hyopneumoniae surface proteins that interact with host extracellular matrix: efficacy testing of candidate vaccines in swine. Over 90% of Australian commercial pig production facilities are affected by Mycoplasma hyopneumoniae, the causative agent of swine enzootic pneumonia. This disease causes economic losses in Australia of over $20 million per annum and up to $1 billion per annum in major swine rearing countries worldwide. This project will determine the protective efficacy of new generation vaccines against M. hyopneumoniae, which aim to block the colonisation process and prevent disease .Read moreRead less
Identification and characterisation of Mycoplasma hyopneumoniae surface-molecules that interact with the host epithelium. Mycoplasma hyponeumoniae causes porcine enzootic pneumonia, a disease that significantly impacts swine production. Current vaccines are unable to prevent colonisation of the respiratory tract and are costly to produce and administer. The expression of microbial adhesins that mediate adherence to the extracellular matrix is considered the initial step in host colonisation for ....Identification and characterisation of Mycoplasma hyopneumoniae surface-molecules that interact with the host epithelium. Mycoplasma hyponeumoniae causes porcine enzootic pneumonia, a disease that significantly impacts swine production. Current vaccines are unable to prevent colonisation of the respiratory tract and are costly to produce and administer. The expression of microbial adhesins that mediate adherence to the extracellular matrix is considered the initial step in host colonisation for many bacterial pathogens. We propose to identify M. hyopneumoniae cell surface moleculaes that interact with components of the extracellular matrix. Targetting these cell surface molecules will lead to therapeutics that prevent disease and block colonisation, eventually eradicating the host pathogen from pig production facilities.Read moreRead less
Proteomics and vaccine development in swine dysentery. Swine dysentery is an infectious disease of significant economic importance caused by Brachyspira hyodysenteriae. There is no effective vaccine available. This project will combine modern techniques in microbial genomics and proteomics to identify outer membrane proteins of B. hyodysenteriae and evaluate their role as candidate vaccine antigens.
Subspecies distribution and virulence of Streptococcus uberis. Streptococcus uberis is a significant cause of bovine mastitis. Attempts to produce a successful vaccine against S. uberis have been hampered by the lack of knowledge of phylogenetic relationships within the species and virulence mechanisms. It is uncertain whether pathogenic strains are clonal or are acquired opportunistically from a diverse population in the environment. This project aims to examine the phylogenetic structure of ....Subspecies distribution and virulence of Streptococcus uberis. Streptococcus uberis is a significant cause of bovine mastitis. Attempts to produce a successful vaccine against S. uberis have been hampered by the lack of knowledge of phylogenetic relationships within the species and virulence mechanisms. It is uncertain whether pathogenic strains are clonal or are acquired opportunistically from a diverse population in the environment. This project aims to examine the phylogenetic structure of S. uberis by multilocus sequence typing and investigate control of virulence gene expression in S. uberis. The information obtained will be used to improve the formulation of a bovine mastitis vaccine developed by RMIT University and Vet Biosearch.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100911
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
The mechanisms driving microbial navigation in marine systems. This project aims to apply advanced video-microscopy to characterise microbial motion at the single cell level, interrogating their navigational responses in precisely controlled physical and chemical conditions. Ocean carbon cycling is driven by the concerted action of marine microbes, but the fine-scale interactions between these microbes and their physical and chemical environments remains elusive. The project findings will unrave ....The mechanisms driving microbial navigation in marine systems. This project aims to apply advanced video-microscopy to characterise microbial motion at the single cell level, interrogating their navigational responses in precisely controlled physical and chemical conditions. Ocean carbon cycling is driven by the concerted action of marine microbes, but the fine-scale interactions between these microbes and their physical and chemical environments remains elusive. The project findings will unravel the fundamental processes governing microbial motion in real environments, and develop the mechanistic modelling tools required to make quantitative ecosystem-level predictions of how soil-atmosphere-water-marine systems respond in the face of environmental change.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100636
Funder
Australian Research Council
Funding Amount
$376,300.00
Summary
The role of marine microbes in the global carbon cycle. This project aims to unravel microbiological processes in the ocean to help quantify the ecosystem services carried out by microbes that support our economy and environment. By recycling vital nutrients, microbes form the basis of the marine food web. In Australia, their contributions support fisheries worth $4.2 billion. Their role in carbon cycling also controls our climate. Yet, their direct productivity remains unquantified. Technical l ....The role of marine microbes in the global carbon cycle. This project aims to unravel microbiological processes in the ocean to help quantify the ecosystem services carried out by microbes that support our economy and environment. By recycling vital nutrients, microbes form the basis of the marine food web. In Australia, their contributions support fisheries worth $4.2 billion. Their role in carbon cycling also controls our climate. Yet, their direct productivity remains unquantified. Technical limitations have restricted our ability to identify the key microbes most responsible for ocean carbon cycling, and to measure their impact. This project plans to combine new approaches in microfluidics, chemistry and oceanography to quantify carbon uptake by individual microbes and provide new understanding of microbe-mediated chemical cycling processes.Read moreRead less
New tools to decipher, predict and manage pacific oyster mortality episodes. This project aims to unite cutting-edge genomic and molecular biological tools with novel quantitative modelling analyses to identify the mechanisms behind oyster disease events. Oyster farming contributes almost $100 million to the Australian economy each year and is a cornerstone of coastal communities, but has been decimated by diseases that threaten this important primary industry. While some causative pathogens hav ....New tools to decipher, predict and manage pacific oyster mortality episodes. This project aims to unite cutting-edge genomic and molecular biological tools with novel quantitative modelling analyses to identify the mechanisms behind oyster disease events. Oyster farming contributes almost $100 million to the Australian economy each year and is a cornerstone of coastal communities, but has been decimated by diseases that threaten this important primary industry. While some causative pathogens have been identified, the environmental catalysts of oyster disease remain a mystery. The expected outcome of this project is an innovative coupling of tools that provides new capacity to forecast disease events, delivering the Australian oyster industry a powerful platform to predict, manage and prevent costly disease outbreaks. By identifying environmental thresholds and oyster disease danger periods, an expected outcome of this project is the development of new oyster farming strategies aimed at avoiding multi-million dollar losses associated with disease outbreaks.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100525
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Mucus control: Applying concepts from bacteriophage-mucus interactions. This project aims to examine how mucus-adherent bacteriophage interact with bacteria in mucus as a mechanism to manipulate microbiomes. Bacterial infections at mucosal surfaces in animals are a serious global health threat. Traditionally antibiotics have been used to curb mucosal infections, but antibiotic resistance means new therapies are urgently needed. Bacteriophage – viruses that infect bacteria – can kill bacteria and ....Mucus control: Applying concepts from bacteriophage-mucus interactions. This project aims to examine how mucus-adherent bacteriophage interact with bacteria in mucus as a mechanism to manipulate microbiomes. Bacterial infections at mucosal surfaces in animals are a serious global health threat. Traditionally antibiotics have been used to curb mucosal infections, but antibiotic resistance means new therapies are urgently needed. Bacteriophage – viruses that infect bacteria – can kill bacteria and might provide a layer of antimicrobial immunity in animal mucus. The anticipated outcomes are resolving how bacteriophage control bacteria within mucus, and applying concepts to bioengineer mucosal microbiomes.Read moreRead less
Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The pro ....Why certain viruses don't get along in mosquitoes. The molecular mechanism. The overall goal of this project is to obtain an understanding of how certain insect-only viruses make mosquitoes incapable of transmitting diseases. These viruses, called insect-specific flaviviruses, can be employed as biocontrol agents for mosquito-borne human and veterinary diseases. However as it is currently unknown how exactly they affect mosquitoes, the safety and efficacy of their use can't be predicted. The proposed project will dissect the very intricate mechanisms of interactions between insect-specific flaviviruses and mosquitoes and explain how exactly they prevent disease transmission. It should generate novel fundamental knowledge, implement innovative methodologies and provide training for students and junior scientist. Read moreRead less