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The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Megalithic Connections: Imperilled Cultural Heritage in Laos and India. This interdisciplinary project aims to document and explore the cultural connections between the geographically disparate megalithic cultures of Laos and India and create an enduring digital record of these threatened cultural assets. Integrating archaeological science and pioneering data capture technologies, the project will create globally significant new knowledge; advance heritage management processes including transfer ....Megalithic Connections: Imperilled Cultural Heritage in Laos and India. This interdisciplinary project aims to document and explore the cultural connections between the geographically disparate megalithic cultures of Laos and India and create an enduring digital record of these threatened cultural assets. Integrating archaeological science and pioneering data capture technologies, the project will create globally significant new knowledge; advance heritage management processes including transferrable exploratory technologies; and help underpin economic, social and cultural benefit in these regions. With an increasing awareness of the need to conserve global cultural assets, Australia will take the lead in developing breakthrough technological solutions and new cross-country research and practitioner capability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100054
Funder
Australian Research Council
Funding Amount
$1,341,398.00
Summary
Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant ad ....Dedicated High-throughput 3D-Electron Diffractometer. This proposal aims to install the first dedicated high-throughput 3D-electron diffractometer in the Southern Hemisphere, and one of the first in the world. It will be able to rapidly solve the atomic-scale structures of molecules and materials for which this is now extremely difficult and time-consuming – or impossible – due to the inability to grow large enough crystals for traditional X-ray diffraction. It will thus provide a significant advantage for chemists, physicists, biologists, geologists, and engineers who rely on detailed structural knowledge to rationally optimise the properties of their compounds, from pharmaceutical activity to carbon capture to superconductivity, to the substantial benefit of multiple national priority areas.Read moreRead less
Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of mul ....Towards 2050 - managing recovery of Australia's coral reefs. The coral reefs of Australia contribute over $6 bn each year to the economy. However, the reefs of Australia, in addition to those worldwide, are threatened by coral bleaching driven by anthropogenic climate change. If we are to preserve the economic, social and ecosystem value of these environments, it is essential that we are able to better manage the recovery of reefs from bleaching events. This project will utilise a variety of multi-disciplinary approaches, ranging from future climate models, historical satellite data to in-field experimentation to fill fundamental knowledge gaps in our understanding of coral bleaching recovery and delivery a variety of management and stakeholder relevant outputs.Read moreRead less
Beyond migration and diffusion: The prehistoric mobility of people & ideas. The project plans to build on the strength of current collaborations between archaeologists and geochemists to ask novel questions about the movement of people and ideas in prehistory. The project plans to examine spatial and temporal patterns in population mobility to clarify their relationship with the appearance of new and exotic materials, technologies and practices. The project focuses on the ways in which the movem ....Beyond migration and diffusion: The prehistoric mobility of people & ideas. The project plans to build on the strength of current collaborations between archaeologists and geochemists to ask novel questions about the movement of people and ideas in prehistory. The project plans to examine spatial and temporal patterns in population mobility to clarify their relationship with the appearance of new and exotic materials, technologies and practices. The project focuses on the ways in which the movement of individuals and groups of people is both an instigator and a response to sociocultural change, using both key European and Pacific Island examples, to help build a comparative archaeology of phenomena of rapid social and economic change, with pertinence to general theories of innovation and adoption.Read moreRead less
Barriers and pathways to development of Indigenous traditional medicines. This project aims to explore how Australian regulatory systems can better support Aboriginal and Torres Strait Islander Traditional Knowledge (TK) holders to commercialise their traditional medicines. Focusing on the mudjala plant and working with the Kimberley’s Nyikina people, the project should generate new anthropological methods for documenting TK related to traditional medicine, new models for regulating traditional ....Barriers and pathways to development of Indigenous traditional medicines. This project aims to explore how Australian regulatory systems can better support Aboriginal and Torres Strait Islander Traditional Knowledge (TK) holders to commercialise their traditional medicines. Focusing on the mudjala plant and working with the Kimberley’s Nyikina people, the project should generate new anthropological methods for documenting TK related to traditional medicine, new models for regulating traditional medicinal products, and pharmacological insights into traditional methods of activating the plant. Additional expected outcomes include unlocking the significant, untapped potential for Indigenous Australians to benefit from the development of traditional medicine products regulated by the Therapeutic Goods Administration.Read moreRead less
Predicting genetic exchange between species under climate change. This project aims to resolve the factors that lead to the mixing of species’ gene pools, with a focus on whether climate change will increase such mixing, possibly leading to extinction by genetic swamping.
The significance is that the project would improve our understanding of speciation and species’ vulnerability to rapid climate change through genetic mixing; a largely overlooked process.
Key outcomes would be to generate new k ....Predicting genetic exchange between species under climate change. This project aims to resolve the factors that lead to the mixing of species’ gene pools, with a focus on whether climate change will increase such mixing, possibly leading to extinction by genetic swamping.
The significance is that the project would improve our understanding of speciation and species’ vulnerability to rapid climate change through genetic mixing; a largely overlooked process.
Key outcomes would be to generate new knowledge of a fundamental evolutionary process and extend the toolbox of biodiversity managers facing rapid environmental change.
The project would benefit Australia by highlighting our unique biodiversity and scientific capability, and by training early career researchers in advanced evolutionary biology.Read moreRead less
The First Polynesians: Their Origins, Lifeways and Environmental Challenges. This project uses an interdisciplinary approach to examine the biological, cultural and environmental factors underpinning the Polynesian people through a study of their ancient homeland in Tonga. Early Polynesian society developed 2650-2350 years ago, but little is known about the people, their culture and how sea-level fall impacted subsistence and settlement. The proposed study’s goal is to fill this gap in human kno ....The First Polynesians: Their Origins, Lifeways and Environmental Challenges. This project uses an interdisciplinary approach to examine the biological, cultural and environmental factors underpinning the Polynesian people through a study of their ancient homeland in Tonga. Early Polynesian society developed 2650-2350 years ago, but little is known about the people, their culture and how sea-level fall impacted subsistence and settlement. The proposed study’s goal is to fill this gap in human knowledge about our Pacific neighbours using a unique skeletal assemblage, excavated cultural remains and advanced mapping of palaeo-sea-level markers that will improve understanding of the impact of environmental change on human societies in our region.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100953
Funder
Australian Research Council
Funding Amount
$413,013.00
Summary
Engaging Rural Knowledges in Education for Sustainable Community Futures. This project aims to enhance understanding of the existing and unique knowledges in rural, regional and remote communities and how these can be used to enhance achievement in contemporary, metropolitan-focused, education. The project will generate new understandings about rural knowledge, related influences upon student curriculum access and achievement, and how rural, regional and remote communities understand educational ....Engaging Rural Knowledges in Education for Sustainable Community Futures. This project aims to enhance understanding of the existing and unique knowledges in rural, regional and remote communities and how these can be used to enhance achievement in contemporary, metropolitan-focused, education. The project will generate new understandings about rural knowledge, related influences upon student curriculum access and achievement, and how rural, regional and remote communities understand educational success. Through detailed analysis of data from systems, community focus groups, and school case-studies in six rural, regional and remote communities this project expects to advance knowledge to help make education better meet the needs of rural, regional and remote communities. Read moreRead less
U/Th dating of coral mortality and recovery rates in the Great Barrier Reef. This project aims to use high-efficiency U-Th geochronology and palaeoecology to identify past coral mortality events and community changes in the inshore Great Barrier Reef (GBR) and quantify subsequent recovery rates across a water quality gradient. These records will then be linked to natural and human impacts, especially since European settlement. The project outcomes will improve understanding of past disturbances ....U/Th dating of coral mortality and recovery rates in the Great Barrier Reef. This project aims to use high-efficiency U-Th geochronology and palaeoecology to identify past coral mortality events and community changes in the inshore Great Barrier Reef (GBR) and quantify subsequent recovery rates across a water quality gradient. These records will then be linked to natural and human impacts, especially since European settlement. The project outcomes will improve understanding of past disturbances and recovery rates in the GBR ecosystem and help focus management in the face of increased human pressure and environmental changes.Read moreRead less