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Targeting Glycointeractions To Generate New Opportunities To Treat And Prevent Bacterial Infections.
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
Bacteria and bacterial toxins can interact with complex sugar structures on human cells called glycans. My research team has identified new and important glycan interactions used by bacteria that cause diseases ranging from pneumonia, meningitis and food borne infections to urinary tract and sexually transmitted diseases. Now that these interactions have been discovered, they can be exploited to create drugs and vaccines that may treat and prevent disease by blocking the glycan interactions.
Halting The Spread Multidrug Resistant Uropathogenic E. Coli
Funder
National Health and Medical Research Council
Funding Amount
$687,975.00
Summary
Uropathogenic Escherichia coli (UPEC) is a major cause of urinary tract infection (UTI) and increasingly associated with resistance to multiple antibiotics. This project will study the virulence of multidrug resistant UPEC and use this knowledge to develop new approaches to treat and prevent UTI. The outcomes will be applicable to one of the most common infectious diseases of humans and have broad-reaching impact on our understanding of other infections caused by Gram-negative pathogens.
I am a structural biologist with a background in pharmacy. My research focuses on dissecting the molecular mechanisms of disease-causing proteins to underpin the development of new and improved therapeutics
Pathogenesis, Treatment And Prevention Of Bacterial Infectious Diseases
Funder
National Health and Medical Research Council
Funding Amount
$852,458.00
Summary
Bacterial infectious diseases remain a serious threat to human health, accounting for over 10 million deaths each year. My research program aims to better understand the dynamic interactions between major disease-causing bacteria and their human hosts, and to directly apply this new knowledge to the development of improved vaccines and novel treatment strategies. These are urgently needed to combat bacterial infectious diseases in the 21st century.
Improving The Prevention, Treatment And Management Of Cardiovascular & Chronic Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The identification, prevention and management of cardiovascular and chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises modern epidemiological research methods involving large scale clinical trials, registries and epidemiological modelling to advance our understanding and provide new directions for cardiovascular disease prevention and management.
Ovarian and endometrial cancer affect >3,200 women each year in Australia and 3 or 4 women die from these cancers every day. The overall aim of my program of research is to reduce the burden of these cancers in future generations of Australian women by increasing our understanding of (i) what causes them, (ii) how we can optimise patient management to enhance patient outcomes and (ii) how lifestyle changes might improve quality and life and survival, for women who are diagnosed with them.
Striking The Balance: Combining Best Patient Outcomes And Cost-effective Interventions To Manage Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$782,370.00
Summary
This research will combine effective patient outcomes with strategic spending of health dollars. Through detailed analyses of current and recent clinical trials on cardiovascular disease, this project will identify treatments that provide the most benefit to patients’ quality of life and, crucially, will also be the most cost-effective to fund. This will pave the way for similar processes to be used in other areas of health to develop cost-effective healthcare programs for vulnerable groups.
New Antibiotics And Treatment Methods Against Drug-resistant Bacteria
Funder
National Health and Medical Research Council
Funding Amount
$766,468.00
Summary
Infectious disease is a leading cause of death, and the emergence of "superbugs" in the community and hospitals is of grave concern. We are developing new, powerful antibiotics that can kill superbugs using ‘forgotten’ drugs from the 1970s. These will combat bacteria that cause pneumonia, skin and urinary track infections; diseases that cause death and discomfort for thousands of Australians today. We will also develop methods to directly remove bacteria from blood infections.
Infertility remains a devastating disease for many couples, despite the success of IVF, as treatment is often unsuccessful, or remains out-of-reach for both health and/or financial reasons. My fellowship aims to improve our understanding of some of the causes of infertility in women. This will translate to a new infertility treatment that is safer for their health and provides for improved long-term health outcomes for their children.