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Mitochondrial Dysfunction In Cardiac Hypertrophy And Failure
Funder
National Health and Medical Research Council
Funding Amount
$164,821.00
Summary
Heart failure is a disease of wide prevalence in the Western World. In addition to the human toll of heart failure, the economic impact is highly substantial. It remains unclear what causes heart failure, but the effects of calcium and free radicals produced in the mitochondria on muscle function are generally accepted as major contributors. The aim of this project is to understand how calcium and free radicals interact with each other and the mechanisms by which they reduce heart function.
The Potential Of Blocking Translation Initiation For Cancer Therapy
Funder
National Health and Medical Research Council
Funding Amount
$347,792.00
Summary
Treatment of many cancers remains unsatisfactory and new drugs for treating them are urgently required. By determining how a new class of anti-cancer drugs kills cancer cells and whether they might also affect normal cells, we can determine how they can be optimally given to patients suffering from cancer.
Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
Structure Determination Of The Mammalian Ryanodine Receptor
Funder
National Health and Medical Research Council
Funding Amount
$377,397.00
Summary
Heart failure is the leading cause of death worldwide. We will determine the structure of the ryanodine receptor, a calcium channel involved in initiating contraction of cardiac and skeletal muscle. Detailed insights into the function of the ryanodine receptor will result from this work. An atomic structure of the cardiac ryanodine receptor will assist in the development of improved ryanodine receptor inhibitors to prevent and treat congestive heart failure.
Identification Of Regulatory Protein Interactions On The CRH Promoter
Funder
National Health and Medical Research Council
Funding Amount
$216,600.00
Summary
CRH made in the brain controls our response to stress, and when made by the placenta it controls when birth will occur. Changes to the stress response can have important implications in heart disease, cancer, obesity and many other diseases. 70% of neonatal death is a result of premature birth, and pre-term babies that survive are more likely to have intellectual handicap or cerebral palsy. This research will help us understand CRH production during stress and pregnancy.
Understanding The Role Of Circular RNAs In Neuronal Biology Using RNA-targeting CRISPR/Cas9
Funder
National Health and Medical Research Council
Funding Amount
$398,097.00
Summary
The regulation of gene expression through a process known as RNA splicing has been shown to be at the heart of a number of processes required for brain development, memory and learning, and is often dysregulated in a number of neurological diseases. Circular RNAs (circRNAs) have been recently shown to be a relatively abundant class of spliced RNA that are specifically enriched in brain tissue. In this project, I aim to understand the roles of circRNAs in neuronal development.