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Novel Babesia proteins and their roles in the pathogenesis of tick fever. This project aims at gaining a deep understanding of the biology of Babesia parasites and how they cause tick fever in cattle. The project expects to discover novel parasite proteins involved in the development and persistence of tick fever and identify their functional role in infection. The main expected outcome is the discovery of parasite proteins that are critical for infection and pathogenesis of cattle tick fever. T ....Novel Babesia proteins and their roles in the pathogenesis of tick fever. This project aims at gaining a deep understanding of the biology of Babesia parasites and how they cause tick fever in cattle. The project expects to discover novel parasite proteins involved in the development and persistence of tick fever and identify their functional role in infection. The main expected outcome is the discovery of parasite proteins that are critical for infection and pathogenesis of cattle tick fever. The findings will contribute to the development of future novel vaccines to control tick fever, with significant economic benefits for the beef and dairy industries worldwide.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100121
Funder
Australian Research Council
Funding Amount
$452,824.00
Summary
Effects of environmental heat stress on male fertility in livestock species. This project aims to address the role of ambient heat stress in animal fertility by examining its mechanisms and developing treatments to alleviate its effects. Using an interdisciplinary approach that brings together veterinary sciences, reproductive biology, biochemistry and bioinformatics, the project expects to improve our understanding of how high environmental temperatures lead to reduced fertility, pregnancy loss ....Effects of environmental heat stress on male fertility in livestock species. This project aims to address the role of ambient heat stress in animal fertility by examining its mechanisms and developing treatments to alleviate its effects. Using an interdisciplinary approach that brings together veterinary sciences, reproductive biology, biochemistry and bioinformatics, the project expects to improve our understanding of how high environmental temperatures lead to reduced fertility, pregnancy loss and compromised inheritance in large animals, and to develop effective interventions. The resulting benefits include enhanced productivity and resilience of Australia’s livestock industries in the face of a changing climate.
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Industrial Transformation Research Hubs - Grant ID: IH210100051
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
The ARC Research Hub for Digital Bioprocess Development. The ARC Hub for Digital Bioprocess Development aims to assist the Biopharma industry by increasing digital innovation, productivity and competitiveness. An interdisciplinary team of engineers, scientists and computing specialists will develop digitally integrated advanced manufacturing processes and a platform for industry adoption. The program will address key bioprocessing research challenges and develop new process and digital models th ....The ARC Research Hub for Digital Bioprocess Development. The ARC Hub for Digital Bioprocess Development aims to assist the Biopharma industry by increasing digital innovation, productivity and competitiveness. An interdisciplinary team of engineers, scientists and computing specialists will develop digitally integrated advanced manufacturing processes and a platform for industry adoption. The program will address key bioprocessing research challenges and develop new process and digital models that can predict and optimise manufacturing processes, resulting in greater yields, faster and more flexible processes and enhanced product stability. The Hub will transform biopharmaceutical manufacturing and unlock growth opportunities to forge an internationally competitive Australian Biopharma sector.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC170100016
Funder
Australian Research Council
Funding Amount
$3,123,492.00
Summary
ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therap ....ARC Training Centre for Personalised Therapeutics Technologies. The ARC Training Centre for Personalised Therapeutics Technologies aims to create and develop the skills and technology to benefit from the transformative impacts that cell/organ-on-a-chip technology will have on the medtech/pharma industries. By combining microfluidics-based/real-time technologies with personalised medicine the Training Centre will provide industry growth opportunities through improved screening of potential therapeutics. The use of an individual patient’s cellular and molecular research findings will ultimately enable personalised diagnostic and therapeutic decisions.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220101210
Funder
Australian Research Council
Funding Amount
$451,634.00
Summary
Deciphering molecular genetic mechanisms underlying chromatin interactions. This project aims to generate the high confidence map of enhancer-promoter links in 61 tissues and cells through robust integration of novel machine learning tools with genomic and epigenomic datasets. Understanding which key elements in the genome may be important to fine-tune gene expression is essential for understanding biological pathways. The expected outcomes include i) New tools to robustly identify true chromati ....Deciphering molecular genetic mechanisms underlying chromatin interactions. This project aims to generate the high confidence map of enhancer-promoter links in 61 tissues and cells through robust integration of novel machine learning tools with genomic and epigenomic datasets. Understanding which key elements in the genome may be important to fine-tune gene expression is essential for understanding biological pathways. The expected outcomes include i) New tools to robustly identify true chromatin pairs; ii) Comperehensive maps of regulatory interactomes in 61 tissues & cells, which will provide a roadmap for interpreting & prioritising noncoding variants.
This should provide significant benefit to Australia's capacity for cutting-edge genomics research through fundamental understanding of gene regulation mechanism.Read moreRead less