Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS rese ....Identifying genes that influence clinical course and susceptibility in multiple sclerosis. This project aims to identify the genetic basis of multiple sclerosis (MS), the most common neurologic disease in young Australian adults. MS urgently needs research to identify predisposition, aid early diagnosis and provide bona fide molecular targets for new therapies. This will benefit people with MS and those susceptible to it. Crucial new knowledge identified will benefit other major areas of MS research including epidemiology, immunology and neurobiology. Collaboration of 8 major Australian institutions is also important for this project and future studies. The team will have access to a new national MS GeneBank (platform) with samples from 2240 patients that should generate findings important to world-wide MS genetic knowledge.Read moreRead less
Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that ....Identifying the specific structural features of metallothionein that regulate its ability to modulate astrogliosis. This project contributes directly to the Designated National Research Priority 2 and could potentially have a significant impact upon the broader Australian Community by identifying a novel and powerful therapeutic agent based upon metallothionein proteins with the ultimate aim of helping patients who have a brain injury or a neurodegenerative disease. It is important to note that the partnership between UTAS and Bestenbalt LLC is a critical step in the development of these exciting research discoveries into commercially viable outcomes for the Australian Biotechnology Industry and the broader Australian community.Read moreRead less
Development of an implantable blood flow and pressure monitor for pulmonary hypertension. The aim is to develop an implantable device for continuous measurement of blood pressure and flow rate in the pulmonary artery. The device is to store data and download it on request to an external device. Development steps include design of the sensor lead incorporating impedance electrodes and a pressure transducer, numerical modelling of the electrode system, characterising pressure and flow waveforms f ....Development of an implantable blood flow and pressure monitor for pulmonary hypertension. The aim is to develop an implantable device for continuous measurement of blood pressure and flow rate in the pulmonary artery. The device is to store data and download it on request to an external device. Development steps include design of the sensor lead incorporating impedance electrodes and a pressure transducer, numerical modelling of the electrode system, characterising pressure and flow waveforms for condensed storage, establishing flow sensor and blood flow relationships and assessment of sensor stability and calibration demands. The device will facilitate research in pulmonary hypertension and may lead to clinical devices for monitoring effectiveness of treatment.Read moreRead less
Social acceptability of forest management options: Landscape level visualisation and evaluation. Sustainable forest policy requires social acceptance. Prior research has investigated relative acceptability of options at a forest stand level. However, we have insufficient understanding of public acceptance of forest management systems implemented across the wider landscape. Only detailed knowledge of public reaction to social, environmental and economic impacts and the trade-offs involved can red ....Social acceptability of forest management options: Landscape level visualisation and evaluation. Sustainable forest policy requires social acceptance. Prior research has investigated relative acceptability of options at a forest stand level. However, we have insufficient understanding of public acceptance of forest management systems implemented across the wider landscape. Only detailed knowledge of public reaction to social, environmental and economic impacts and the trade-offs involved can reduce the divisive nature of the forest management debate. This project will use interactive, still and animated computer representations of landscapes to examine social acceptability of alternatives to clearfell harvesting. This knowledge will be integrated with biophysical data to improve management of forested landscapes.Read moreRead less
Acceptability of Forest Harvesting Systems. Fierce public debate over forest management has prompted forest agencies to develop and test alternative harvesting systems. This project will examine community response to these harvesting and regeneration options. It will avoid the biases of existing research by developing an interactive simulation of the forest environment that will allow participants to view visual, ecological and economic outcomes of harvest options, as well as changes over time ....Acceptability of Forest Harvesting Systems. Fierce public debate over forest management has prompted forest agencies to develop and test alternative harvesting systems. This project will examine community response to these harvesting and regeneration options. It will avoid the biases of existing research by developing an interactive simulation of the forest environment that will allow participants to view visual, ecological and economic outcomes of harvest options, as well as changes over time as forest regenerates. Public judgements of the acceptability of harvesting options will be integrated with the outcomes of related biophysical studies to identify socially and ecologically sustainable management options for Australian native forests.Read moreRead less
The neural effects of torture. Torture affects millions of people and causes much long-term psychological harm. This project aims to identify the effects that torture has on the brain by studying torture survivors in the context of a range of brain imaging technologies that will lead to development of a model of the neural effects of torture to guide better treatments.