Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the pirifo ....Coding of olfactory information in the piriform cortex. This project aims to understand how electrical activity in the primary olfactory (piriform) cortex enables mice to recognise and remember odours. By using optical recording techniques together with genetic tools, the project expects to generate new knowledge about how the mammalian brain builds internal representations of the external world. Specific outcomes of the project include new insights into the functional architecture of the piriform cortex and fresh understanding of how olfactory information is encoded and stored in neural circuits. More broadly, the project aims to advance our understanding of how the brain works, with benefits for future improvements in artificial intelligence and brain-machine interfaces.Read moreRead less
Structure and function of heterodimeric amino acid transporters. Recently a new family of amino acid transporters has been identified, the members of which are involved in the delivery of amino acids between cells and tissues. All members display a rather unusual structure in that they require two subunits to be functional. The main aim of this study is to investigate the interaction between large and small subunits. The study will give insight how membrane proteins form complexes in the membran ....Structure and function of heterodimeric amino acid transporters. Recently a new family of amino acid transporters has been identified, the members of which are involved in the delivery of amino acids between cells and tissues. All members display a rather unusual structure in that they require two subunits to be functional. The main aim of this study is to investigate the interaction between large and small subunits. The study will give insight how membrane proteins form complexes in the membrane and how these interactions affect the function of a complex membrane protein.Read moreRead less
MemberGuard: Protecting Machine Learning Privacy from Membership Inference. Machine Learning has become a core part of many real-world applications. However, machine learning models are vulnerable to membership inference attacks. In these attacks, an adversary can infer if a given data record has been part of the model's training data. In this project, the team aims to develop new techniques that can be used to counter these attacks, such as 1) new analytical models for membership leakage, 2) ne ....MemberGuard: Protecting Machine Learning Privacy from Membership Inference. Machine Learning has become a core part of many real-world applications. However, machine learning models are vulnerable to membership inference attacks. In these attacks, an adversary can infer if a given data record has been part of the model's training data. In this project, the team aims to develop new techniques that can be used to counter these attacks, such as 1) new analytical models for membership leakage, 2) new methods for susceptibility diagnosis, 3) new defences that leverage privacy and utility. Data-oriented services are estimated to be valuable assets in the future. These techniques can help Australia gain cutting edge advantage in machine learning security and privacy and protect its intellectual property on these services.Read moreRead less
DeepHoney: Automatic Honey Data Generation for Active Cyber Defence . This project aims to enhance the security of networks and information systems by empowering them with intelligent deception techniques to achieve proactive attack detection and defence. In recent times, the fictitious environment – honeypot designed by human experience becomes popular to attract attackers and capture their interactions. However, rules-based construction of honeypots fails in preserving the privacy, boosting th ....DeepHoney: Automatic Honey Data Generation for Active Cyber Defence . This project aims to enhance the security of networks and information systems by empowering them with intelligent deception techniques to achieve proactive attack detection and defence. In recent times, the fictitious environment – honeypot designed by human experience becomes popular to attract attackers and capture their interactions. However, rules-based construction of honeypots fails in preserving the privacy, boosting the attractiveness and evolving the system. The project expects to advance deep learning and yield novel DeepHoney technologies with associated publications and open-source software. This should benefit science, society, and the economy by building the next generation of active cyber defence systems. Read moreRead less
Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutritio ....Amino acids as nutrients - the molecular basis of amino acid absorption in kidney and intestine. Nutrition is a critical factor for well being and health. This is highlighted by the increase in frequency of type II diabetes and the obesity problem that all societies with a western diet face. Most studies in nutrition focus on fat and carbohydrates because of their direct involvement in obesity and diabetes. Proteins and the resulting peptides and amino acids, however, form 10-15% of our nutrition. At a time where protein-rich diets are recommended to fight obesity and diabetes, it is important to understand the basis of protein absorption and metabolism. This project investigates the mechanism and mediators of amino acid absorption in kidney and intestine. Read moreRead less
Privacy-preserving Biometrics based Authentication and Security. Password based authentication systems cannot verify genuine users. Biometric authentication can address this issue. However, the booming IoT applications and cloud computing require that the biometric authentication must be conducted in the privacy-protected setting in order to comply with privacy protection legal regulations. Latest reports show that current biometric authentication systems, under protected setting, exhibit poor ....Privacy-preserving Biometrics based Authentication and Security. Password based authentication systems cannot verify genuine users. Biometric authentication can address this issue. However, the booming IoT applications and cloud computing require that the biometric authentication must be conducted in the privacy-protected setting in order to comply with privacy protection legal regulations. Latest reports show that current biometric authentication systems, under protected setting, exhibit poor authentication performance, which is not commercially applicable. This project aims to investigate innovative solutions to this issue. The intended deliverables will include deep learning based biometric feature extractor, cancellable biometrics and cloud oriented biometrics security protocols. Read moreRead less
Verified concurrent memory management on modern processors. This project aims to formally verify automatic memory managers in the presence of concurrency and the weakly ordered memory of modern processors. A new framework for verifying memory managers, reusable for a wide range of managed programming languages, target hardware, policies, and algorithms will be developed. Expected technical outcomes include improved techniques to ensure trustworthiness of the foundations on which critical softwar ....Verified concurrent memory management on modern processors. This project aims to formally verify automatic memory managers in the presence of concurrency and the weakly ordered memory of modern processors. A new framework for verifying memory managers, reusable for a wide range of managed programming languages, target hardware, policies, and algorithms will be developed. Expected technical outcomes include improved techniques to ensure trustworthiness of the foundations on which critical software infrastructures are built. This will significantly enhance the security of public and private cyber assets, and deliver applications that are more robust and trustworthy, across a range of critical infrastructure such as transportation, communication, energy and defence.Read moreRead less
Improving neuronal cell function with cell permeable copper complexes. Metal-based drugs offer an exciting new approach to treatment of neurodegeneration. However, little is known about how cells metabolise these drugs and this information is critical for further drug development. This project will determine how metal-based drugs are metabolised by neuronal cells and how this may result in therapeutic benefit.
Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge fo ....Electrical properties of human dendrites. This project aims to determine the electrical properties of dendrites in human neurons. Dendrites are the primary site of synaptic input to neurons and their electrical properties play a key role in information processing in the brain. While we know much about the electrical properties of dendrites in other species, primarily rodents, little is known about the electrical properties of human dendrites. This project aims to address this gap in knowledge for the first time. The results obtained will shed light on the mechanisms the brain uses to process information, and therefore will bring us a step closer to truly understanding ourselves.Read moreRead less
Resolving the Structures of Human Muscarinic M1 and M4 Receptors. Muscarinic receptors are vital for most basic human brain functions. These receptors are changed in schizophrenia and Alzheimer's disease. This project will determine the structure and localisation of two of these receptors in order to i) understand their roles in brain disorders and ii) develop drugs to treat disorders involving them.