A New Paradigm For Class I Cytokine Receptor Activation
Funder
National Health and Medical Research Council
Funding Amount
$954,946.00
Summary
Class I cytokine receptors include around 30 receptors with diverse functions such as controlling metabolism and inflammation. Cytokine receptors are molecular switches on cells that receive signals from other cells and transmit this signal into the cell’s nucleus to control the regulation of genes. This project will determine the molecular mechanisms involved in class I cytokine receptors and use this knowledge to develop novel ways to modulate these receptors for clinical applications.
Macrophage Polarisation And Control Of Pulmonary Inflammation.
Funder
National Health and Medical Research Council
Funding Amount
$895,494.00
Summary
As key immune cells, macrophages are polarised to phenotypes that turn inflammation on or off. In cystic fibrosis, defective macrophage polarisation enhances inflammation and prevents lung repair. We are defining the molecules and cellular pathways that control this process and identifying targets for existing drugs that can be used to reprogram macrophages and restore lung repair to improve patient outcomes.
Legacy2Service: A Novel, Model-Driven Technique for Re-engineering On-Demand, Software Services out of Legacy Applications. The proliferation of software-as-a-service applications from "dotcom" players is raising expectations that other industries will make their critical desktop and mainframe software available as web-enabled software-as-a-service and mobile "apps". However, manually re-engineering legacy software is notoriously costly and frequently unsuccessful. This project will make it easi ....Legacy2Service: A Novel, Model-Driven Technique for Re-engineering On-Demand, Software Services out of Legacy Applications. The proliferation of software-as-a-service applications from "dotcom" players is raising expectations that other industries will make their critical desktop and mainframe software available as web-enabled software-as-a-service and mobile "apps". However, manually re-engineering legacy software is notoriously costly and frequently unsuccessful. This project will make it easier and quicker to turn stand-alone programs into online services by automating much of the process. Specifically, it will develop tools: for analysing program code to identify points to implement service interfaces; for displaying existing and new code dependencies visually; and, to help design and implement new software layers that link legacy services to the web.Read moreRead less
Tissue Ferritin Acts As A Proinflammatory Mediator Of Hepatic Fibrosis In Chronic Liver Disease Via Multiple Receptors In Hepatic Stellate Cells Responsible For Both Binding And Signalling.
Funder
National Health and Medical Research Council
Funding Amount
$777,887.00
Summary
Our research has identified a role for tissue-derived ferritin as a proinflammatory cytokine in hepatic stellate cell biology, the cells responsible for liver scarring (fibrosis) in Haemochromatosis. This proposal will identify the receptor responsible for eliciting ferritin's proinflammatory action and assess its role in fibrosis. This study will have implications in chronic liver diseases of varying aetiologies where elevated serum ferrritin is associated with inflammation.