Long-term Cloud Service Composition. This project proposes an economic model-based framework for the selection and composition of cloud services, thus creating an efficient market for cloud consumers and providers. The project will use economic models that incorporate a range of quality of service (QoS) parameters as a key driver for optimising the selection of cloud services and the acceptance of consumer requests. The main outcomes of this project aim to increase efficiencies in the cloud mark ....Long-term Cloud Service Composition. This project proposes an economic model-based framework for the selection and composition of cloud services, thus creating an efficient market for cloud consumers and providers. The project will use economic models that incorporate a range of quality of service (QoS) parameters as a key driver for optimising the selection of cloud services and the acceptance of consumer requests. The main outcomes of this project aim to increase efficiencies in the cloud market, benefiting consumers and providers.Read moreRead less
Improving provision of a document store as a service in a public cloud. Improving provision of a document store as a service in a public cloud. This project aims to develop a model of document-oriented database correctness and performance that can be applied to cloud-hosted clusters. Many modern web applications rely on document-oriented databases hosted on clusters of virtualised servers from commercial cloud providers. Developers make difficult deployment decisions, such as how to combine data ....Improving provision of a document store as a service in a public cloud. Improving provision of a document store as a service in a public cloud. This project aims to develop a model of document-oriented database correctness and performance that can be applied to cloud-hosted clusters. Many modern web applications rely on document-oriented databases hosted on clusters of virtualised servers from commercial cloud providers. Developers make difficult deployment decisions, such as how to combine data sharding and replication to meet service requirements without any guidance on the degree of precision. This research will allow developers and database administrators to predict how systems will behave in conditions difficult to simulate directly. Ultimately, this is expected to improve the quality and efficiency of services built using document databases.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140101628
Funder
Australian Research Council
Funding Amount
$301,970.00
Summary
Non-Intrusive Resource Sharing for Cloud Data Centre Efficiency. Resource sharing using hardware virtualisation has become increasingly common for cloud data centre efficiency. Such virtualisation allows multiple workloads to share a common set of resources in a single physical machine. In practice, however, these co-located workloads often compete for resources, leading to their resource usage being non-isolable and intrusive. This intrusive resource sharing is a major source of cloud data cent ....Non-Intrusive Resource Sharing for Cloud Data Centre Efficiency. Resource sharing using hardware virtualisation has become increasingly common for cloud data centre efficiency. Such virtualisation allows multiple workloads to share a common set of resources in a single physical machine. In practice, however, these co-located workloads often compete for resources, leading to their resource usage being non-isolable and intrusive. This intrusive resource sharing is a major source of cloud data centre inefficiency. This project will develop non-intrusive resource allocation and scheduling solutions that enable co-located workloads to organically use resources. These solutions exploit the heterogeneity and dynamicity of cloud data centres that are often perceived as the main hurdles of resource management.Read moreRead less
Cognitive Enhancement In Schizophrenia Via Selective Oestrogen Receptor Modulator.
Funder
National Health and Medical Research Council
Funding Amount
$396,380.00
Summary
Cognitive dysfunction in schizophrenia is resistant to treatment and related to poor community functioning and quality of life. In spite of the widely appreciated magnitude of the problem, there is still a critical gap in our knowledge concerning treatments to reverse these cognitive deficits. The proposed research is significant because it will clarify the role of hormones and genes in relation to cognitive deficits in schizophrenia and it may help patients improve their level of functioning.
Molecular Mechanisms Of Receptor Activation And Signalling
Funder
National Health and Medical Research Council
Funding Amount
$571,980.00
Summary
Fundamental to our ability to respond to both immediate and long-term environmental changes and stresses is the coordinated regulation of cellular functions by hormonal and neurotransmitter stimuli. The great majority of such stimuli are sensed by G-protein coupled receptors (GPCR), complex glycoprotein molecules on the surface of most cells that selectively bind and are activated by various hormones and neurotransmitters. Although GPCRs are a superfamily of proteins that now compromise several ....Fundamental to our ability to respond to both immediate and long-term environmental changes and stresses is the coordinated regulation of cellular functions by hormonal and neurotransmitter stimuli. The great majority of such stimuli are sensed by G-protein coupled receptors (GPCR), complex glycoprotein molecules on the surface of most cells that selectively bind and are activated by various hormones and neurotransmitters. Although GPCRs are a superfamily of proteins that now compromise several hundred distinct but structurally-related members, the molecular mechanisms involved in their activation and, thus, their regulation of vital cellular functions, remains unclear. Based on insights that we have gained from the development and characterisation of several alpha1-adrenergic receptor mutants, we have developed a model of receptor activation. In this application we are proposing to further test and to extend the hypotheses underlying this model. Importantly, the functions regulated by GPCR include vital responses, such as the maintenance of circulatory homeostasis by augmenting heart pump function and by constricting vascular smooth muscle to maintain blood pressure. In addition, disordered cellular regulation by GPCR has been implicated in a wide variety of diseases, including hypertension, congestive heart failure and cardiac hypertrophy. Thus, the studies detailed here to further understand the molecular mechanisms of receptor activation have broad implications for our knowledge of critical physiological control systems, and may lead to novel therapeutic approaches to treat a variety of diseases.Read moreRead less
Developing A New Strategy For Treating Demyelinating Peripheral Diseases
Funder
National Health and Medical Research Council
Funding Amount
$496,250.00
Summary
Incomplete remyelination is a significant component of the persistent clinical disability of peripheral demyelinating neuropathy, contributing to conduction deficits and the secondary axonal damage. A crucial therapeutic challenge is to identify ways to promote remyelination. This project aims to develop a new strategy and a novel clinically relevant target for treating peripheral demyelinating neuropathy.
Pushing AR Toward Better Outcomes In Breast And Prostate Cancers
Funder
National Health and Medical Research Council
Funding Amount
$998,754.00
Summary
Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives ....Breast and prostate cancers kill >6000 Australians each year. These cancers are strikingly similar, both driven by hormone receptors that have ‘gone bad’. Current therapies aim to eradicate the receptors. While often effective, therapeutic resistance is common and results in fatal disease. We aim to develop new, less toxic treatments that switch receptor behaviour from good to bad, without destroying them. This should improve quality of life, while preventing drug resistance and loss of lives.Read moreRead less