Early Career Industry Fellowships - Grant ID: IE230100410
Funder
Australian Research Council
Funding Amount
$452,085.00
Summary
Bridging the gap between rockfall theory and engineering practice. Fragmentation is often observed post rockfall events and it is recognised as a critical aspect of adequate rockfall risk management. Yet, rockfall fragmentation is a complex phenomenon still poorly understood and not properly considered in engineering practice. This project aims at developing a theoretical and stochastic fragmentation framework, based on high-quality and comprehensive experimental data, in collaboration with lead ....Bridging the gap between rockfall theory and engineering practice. Fragmentation is often observed post rockfall events and it is recognised as a critical aspect of adequate rockfall risk management. Yet, rockfall fragmentation is a complex phenomenon still poorly understood and not properly considered in engineering practice. This project aims at developing a theoretical and stochastic fragmentation framework, based on high-quality and comprehensive experimental data, in collaboration with leading international industry partners that provide advanced geotechnical design tools to practitioners around the world. The outcomes of the project will bridge the gap between rockfall theory and engineering practice. It will allow for more cost-effective and safer design of rockfall protection structures.Read moreRead less
A novel granular stress sensor for soil exploration. The project aims to develop a novel way to measure the state of soils and improve the perception of soft ground robots by combining advances in sensor development with granular physics. The project expects to produce new insights in geotechnical engineering by utilising innovative sensors compliant with the surrounding medium, thus improving measurements across broader deformation conditions than existing technologies. Expected outcomes includ ....A novel granular stress sensor for soil exploration. The project aims to develop a novel way to measure the state of soils and improve the perception of soft ground robots by combining advances in sensor development with granular physics. The project expects to produce new insights in geotechnical engineering by utilising innovative sensors compliant with the surrounding medium, thus improving measurements across broader deformation conditions than existing technologies. Expected outcomes include an increased ability to prevent soil failures by utilising these sensors to monitor stress levels underground. This should provide significant benefits for saving critical infrastructure from environmental and geotechnical failures, including landslides, tunnel collapses, and tailings dam damages.Read moreRead less
Chemical staples and chemical probes to dissect dynamins cellular roles. Modulation of protein structure drives cellular function. Dynamin GTPase forms at least two macromolecular structures with different cellular functions. The drivers behind these different structures is unknown. In this project we will leverage our discoveries, and planned enhancements, of chemical biology probes that will modulate dynamin activity by inhibiting at three distinct sites, and one site that stimulates dynamin a ....Chemical staples and chemical probes to dissect dynamins cellular roles. Modulation of protein structure drives cellular function. Dynamin GTPase forms at least two macromolecular structures with different cellular functions. The drivers behind these different structures is unknown. In this project we will leverage our discoveries, and planned enhancements, of chemical biology probes that will modulate dynamin activity by inhibiting at three distinct sites, and one site that stimulates dynamin activity. It is known that Dynamin helices and rings are believed responsible for at least three in cell biological functions: in hormone, neutral and receptor internalisation; cellular mitosis and in actin dynamics. Prior to this work we have lacked the tools to understand the role of shape modulation of protein function.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100707
Funder
Australian Research Council
Funding Amount
$450,926.00
Summary
Towards a molecular fingerprint for human-specific endogenous retroviruses. This project aims to understand how ancient viral sequences resident in the human genome can contribute to cellular processes. Using a novel molecular toolbox that combines affinity-directed proximity labelling mass spectrometry and single molecule microscopy, this project will characterise the cellular fingerprint of a human endogenous retrovirus family HERV-K (HML-2). This fingerprint will comprehensively describe how ....Towards a molecular fingerprint for human-specific endogenous retroviruses. This project aims to understand how ancient viral sequences resident in the human genome can contribute to cellular processes. Using a novel molecular toolbox that combines affinity-directed proximity labelling mass spectrometry and single molecule microscopy, this project will characterise the cellular fingerprint of a human endogenous retrovirus family HERV-K (HML-2). This fingerprint will comprehensively describe how expressed HERV-K loci engage with the homeostasis network in human cells. This will provide significant benefits in the form of new knowledge concerning fundamental aspects of cellular homeostasis, and a state-of-the-art molecular biology toolbox ready to explore quantitatively the role of HERV-K in human health and disease.Read moreRead less