Participate-CP: Optimising Participation In Physically Active Leisure For Children With Cerebral Palsy: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,014,872.00
Summary
In Australia, 35,000 people have cerebral palsy, who compared to able-bodied peers, are less active with a greater risk of chronic, life-limiting health conditions. There are currently no effective interventions for children with cerebral palsy to increase their physical activity and participation in active leisure activities. We have promising data about a new intervention, called Participate-CP, which we will test in 80 children with cerebral palsy and compare results to usual therapy care.
Improving Weight Loss By Intermittent Use Of Very Low Energy Diet: The TANGO Diet Trial (Temporary Phases Of Accelerated Weight Loss For Noticeably Greater Outcomes)
Funder
National Health and Medical Research Council
Funding Amount
$660,736.00
Summary
Very low energy diet (VLED) is being increasingly used for the treatment of obesity, but the resultant weight loss is usually transient, partly because it induces powerful adaptive responses that inhibit weight loss and promote regain. We have shown that 'taking a break from dieting' for 2 weeks reduces these adaptive responses. In this project we will thus test whether weight loss outcomes with VLED can be improved via intermittent use, where periods on the VLED are alternated with 'breaks'.
A Life Course Approach To Characterising And Predicting Inactivity And Sedentary Behaviour Of Young Adults
Funder
National Health and Medical Research Council
Funding Amount
$302,006.00
Summary
Poor activity habits are expected to overtake smoking as the leading preventable cause of health burden in Australia. Poor activity habits increase the risk for a shorter life and many health problems such as heart disease, some cancers and diabetes. Young adulthood is an important time for individuals to develop their lifestyle habits. This study will provide the first detailed description of the inactivity habits of Australians in their early 20s and factors we can target before adulthood to e ....Poor activity habits are expected to overtake smoking as the leading preventable cause of health burden in Australia. Poor activity habits increase the risk for a shorter life and many health problems such as heart disease, some cancers and diabetes. Young adulthood is an important time for individuals to develop their lifestyle habits. This study will provide the first detailed description of the inactivity habits of Australians in their early 20s and factors we can target before adulthood to encourage healthy habits.Read moreRead less
Platelet Glycoprotein Proteolysis: Novel Mechanisms And Risk Factors
Funder
National Health and Medical Research Council
Funding Amount
$441,473.00
Summary
Platelets are the richest source of amyloid precursor protein (APP) in the body. Platelet ADAM10 regulates both the expression and function of the major platelet collagen receptor GPVI, and protective APP processing. Coagulation protein Factor X has a role in activation of ADAM10. This activation is disrupted in blood that has been treated with direct oral anticoagulant (DOAC) rivaroxaban. This grant will investigate the implications for people taking rivaroxaban on regulation of APP and GPVI.
The Role Of A Presenilin 2 Truncation (PS2V) In Alzheimer's Disease
Funder
National Health and Medical Research Council
Funding Amount
$552,741.00
Summary
The Presenilin and APP proteins are centrally important in inherited, early onset Alzheimer's disease. We have discovered that a shortened form of Presenilin protein, "PS2V", appears to increase specifically the rate at which the APP protein is cleaved to produce the "Amyloid beta" protein fragment that is found in Alzheimer's disease brains. This occurs when brain cells are under oxidative stress. Understanding this process will facilitate development of appropriate therapeutic strategies for t ....The Presenilin and APP proteins are centrally important in inherited, early onset Alzheimer's disease. We have discovered that a shortened form of Presenilin protein, "PS2V", appears to increase specifically the rate at which the APP protein is cleaved to produce the "Amyloid beta" protein fragment that is found in Alzheimer's disease brains. This occurs when brain cells are under oxidative stress. Understanding this process will facilitate development of appropriate therapeutic strategies for the disease.Read moreRead less
EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Investigating Underlying Mechanisms Linking Type 2 Diabetes With Alzheimer’s Disease Pathology
Funder
National Health and Medical Research Council
Funding Amount
$701,950.00
Summary
With type-2 diabetes representing a major risk factor for neurodegenerative diseases such as Alzheimer's disease, it is important to understand the underlying mechanisms. This project will provide significant insight into how T2D impacts the brain with a focus on how deficiencies in brain inuslin signaling drives neurodegeneration. We will also evaluate novel inuslin like molecules at improving brain insulin siganling and preventing or slowing down the neurodegenerative process.