A novel granular stress sensor for soil exploration. The project aims to develop a novel way to measure the state of soils and improve the perception of soft ground robots by combining advances in sensor development with granular physics. The project expects to produce new insights in geotechnical engineering by utilising innovative sensors compliant with the surrounding medium, thus improving measurements across broader deformation conditions than existing technologies. Expected outcomes includ ....A novel granular stress sensor for soil exploration. The project aims to develop a novel way to measure the state of soils and improve the perception of soft ground robots by combining advances in sensor development with granular physics. The project expects to produce new insights in geotechnical engineering by utilising innovative sensors compliant with the surrounding medium, thus improving measurements across broader deformation conditions than existing technologies. Expected outcomes include an increased ability to prevent soil failures by utilising these sensors to monitor stress levels underground. This should provide significant benefits for saving critical infrastructure from environmental and geotechnical failures, including landslides, tunnel collapses, and tailings dam damages.Read moreRead less
Eruption dynamics and tsunami potential from submarine volcanoes. This project is based on recently acquired seafloor samples and geophysical data from extraordinary deposits at a modern submarine volcano. This project aims to determine the conditions that lead to explosive eruption underwater, the dynamics of associated sediment flows, and if these events can trigger tsunami. Expected outcomes include an unprecedented reconstruction of the architecture of submarine caldera volcanoes, new innova ....Eruption dynamics and tsunami potential from submarine volcanoes. This project is based on recently acquired seafloor samples and geophysical data from extraordinary deposits at a modern submarine volcano. This project aims to determine the conditions that lead to explosive eruption underwater, the dynamics of associated sediment flows, and if these events can trigger tsunami. Expected outcomes include an unprecedented reconstruction of the architecture of submarine caldera volcanoes, new innovative models applicable globally for a richer understanding of volcanic tsunami and eruptions that shape the seafloor. This project will provide significant benefits through mitigation of global marine natural hazards, and by improving knowledge on the volcanic hosts of ore deposits.Read moreRead less
A fundamental study of the role of signal transduction pathways in the regulation of Chlamydia's complex developmental cycle. Chlamydia are unique organisms in the microbial world. They are among the smallest bacteria and yet have a complex two-stage developmental cycle. In addition they are major causes of disease in animals and humans with no vaccines available. We have used the recent flood of full genome sequence data to identify over 30 new cell signalling proteins. By understanding how the ....A fundamental study of the role of signal transduction pathways in the regulation of Chlamydia's complex developmental cycle. Chlamydia are unique organisms in the microbial world. They are among the smallest bacteria and yet have a complex two-stage developmental cycle. In addition they are major causes of disease in animals and humans with no vaccines available. We have used the recent flood of full genome sequence data to identify over 30 new cell signalling proteins. By understanding how these cell signaling proteins are organized into pathways and how this microorganism controls its complex growth and developmental cycle, we will be able to develop novel methods of control. We are at the fore front of international research and therefore uniquely placed to conduct this project.Read moreRead less
A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to ....A study of the nongenomic action of Vitamin D: proposed role of the nuclear VDR and downstream signalling molecules. Vitamin D (1,25D) activates genes in the nucleus through the vitamin D receptor (VDR). 1,25D can also elicit rapid responses at the plasma membrane. This action is critical to the activation of nuclear genes. We hypothesise that a proportion of the nuclear VDR is located at the plasma membrane where it stimulates downstream signalling molecules eg Ras, ERK1/2 and ERK5. We plan to explore this hypothesis and to identify the signalling molecules. We will also investigate our novel finding that a specific Ras isoform is involved in ERK5 activation. The work will provide new information on signalling pathways.Read moreRead less
Structural studies on the mitochondrial protein import machinery. Proteins transported across biological membranes are generally synthesized as precursors with signal sequences. These signal sequences are decoded by one of a number of membrane-specific protein transport machinery, but how this decoding occurs is largely unknown. This proposal aims to understand the structural basis of protein import into the mitochondrion, a poorly understood biological process. This study will enhance signif ....Structural studies on the mitochondrial protein import machinery. Proteins transported across biological membranes are generally synthesized as precursors with signal sequences. These signal sequences are decoded by one of a number of membrane-specific protein transport machinery, but how this decoding occurs is largely unknown. This proposal aims to understand the structural basis of protein import into the mitochondrion, a poorly understood biological process. This study will enhance significantly our understanding of mitochondrial biology, and will also have ramifications for other areas of protein transport.Read moreRead less
Guanylate cyclases - an expanding family critical in plant growth and development. The enzyme guanylate cyclase (GC) forms an important signalling molecule. We have identified unique GC molecules from higher plants. We shall use strategic basic research to determine the biological importance of these novel molecules in plant growth and development. We have formed an international team to achieve these goals and also to develop strong scientific links between Australia and other countries such as ....Guanylate cyclases - an expanding family critical in plant growth and development. The enzyme guanylate cyclase (GC) forms an important signalling molecule. We have identified unique GC molecules from higher plants. We shall use strategic basic research to determine the biological importance of these novel molecules in plant growth and development. We have formed an international team to achieve these goals and also to develop strong scientific links between Australia and other countries such as South Africa. The outcomes will provide new insight into the biological function of the novel GCs. Consequently, the new knowledge is critical to the development of novel biotechnological approaches to benefit sustainable agriculture in Australia.Read moreRead less
Regulation of the actin cytoskeleton by LIM kinase 2. Because the regulation of actin cytoskeleton is essential for many cellular processes including cell motility and the normal function of neurons, it is of great importance to understand its regulation. Elucidation of the molecular and biological mechanisms underlying the actin cytoskeleton including cell motility may enable the identification of novel therapeutic targets for the treatment of diseases such as cancer metastasis, Alzheimer disea ....Regulation of the actin cytoskeleton by LIM kinase 2. Because the regulation of actin cytoskeleton is essential for many cellular processes including cell motility and the normal function of neurons, it is of great importance to understand its regulation. Elucidation of the molecular and biological mechanisms underlying the actin cytoskeleton including cell motility may enable the identification of novel therapeutic targets for the treatment of diseases such as cancer metastasis, Alzheimer disease (AD) and/or Multiple Sclerosis (MS) in which the regulation of the actin cytoskeleton is affected.
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Analysis of the Role of Snapin in the Regulation of SNARE Complex Assembly. The aims of the proposed studies are to investigate the role played by a protein, snapin in the trafficking of membranes and cargo proteins between different compartments inside mammalian cells. Membrane trafficking is a fundamental cellular process that requires a family of related molecules termed SNARES. We have recently discovered that snapin interacts with certain members of the SNARE family, implying a critical rol ....Analysis of the Role of Snapin in the Regulation of SNARE Complex Assembly. The aims of the proposed studies are to investigate the role played by a protein, snapin in the trafficking of membranes and cargo proteins between different compartments inside mammalian cells. Membrane trafficking is a fundamental cellular process that requires a family of related molecules termed SNARES. We have recently discovered that snapin interacts with certain members of the SNARE family, implying a critical role in membrane trafficking. The proposed studies will provide important new insights into the molecular mechanisms underlying the function of both snapin and SNAREs, and membrane trafficking in general.Read moreRead less
Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysica ....Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysical binding assays to characterise compounds that are produced on small scale using parallel chemistry. This approach will enable better chemical probes to be developed more rapidly at lower cost than is currently possible.Read moreRead less
How Large Earthquakes Change Our Dynamically Deforming Planet. The project aims to understand the multiscale dynamics of interacting faults on a global scale using novel computer simulations with unprecedented spatial and temporal resolution. The focus of the research is to investigate the two-way coupling that exists between cycles of great earthquakes on plate boundaries, the global stress field, deformation within the crust, and changes to the Earth's dynamic topography. This is an important, ....How Large Earthquakes Change Our Dynamically Deforming Planet. The project aims to understand the multiscale dynamics of interacting faults on a global scale using novel computer simulations with unprecedented spatial and temporal resolution. The focus of the research is to investigate the two-way coupling that exists between cycles of great earthquakes on plate boundaries, the global stress field, deformation within the crust, and changes to the Earth's dynamic topography. This is an important, foundational question in the emerging field of decadal scale global geodynamics. The tools are intended to improve reference models used to study sea-level changes in response to global ice loss. They support better climate models and improved forward planning tools for at-risk coastal communities.Read moreRead less