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Molecular Pharmacology Of Chemokine Receptor Signalling In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$371,770.00
Summary
Molecular pharmacology is the study of how hormones, neurotransmitters and pharmaceuticals interact with our cells through receptors, which transfer a signal across the cell membrane to change the function of that cell. Chemokine receptors are recognised to play a role in the development of many cancers. Understanding how these receptors work has enormous implications for improving our ability to develop better anti-cancer treatments with fewer side effects.
Allosteric Modulation Of GPCR-mediated Intracellular Signalling In Human Embryonic Stem Cell Derived Cardiomyocytes.
Funder
National Health and Medical Research Council
Funding Amount
$324,598.00
Summary
Adenosine and muscarinic receptors are cell-surface proteins that represent promising targets for a number of conditions. However, the mechanisms linking the activation of these receptors to cellular responsiveness have not been thoroughly investigated in cells of human origin. This study will use novel cutting-edge methods to measure the effects of different classes of drugs on receptor-mediated intracellular signalling in embryonic stem cell derived human cardiac cells.
Pharmacological Investigation Of The Glucagon-Like Peptide-1 Receptor (GLP-1R)
Funder
National Health and Medical Research Council
Funding Amount
$367,948.00
Summary
Family B G protein-coupled receptors represent key therapeutic targets for many conditions, including metabolic, bone, growth and neuronal disorders. However, poor mechanistic understanding of this receptor family impacts on their clinical value. Consequently, this research is aimed at gaining a more comprehensive understanding of the structure and function of the family B glucagon-like peptide-1 receptor through use of new and novel pharmacological techniques.