KRAS- And BRAF-Mediated Methylation Signatures In Colorectal Cancers And Polyps
Funder
National Health and Medical Research Council
Funding Amount
$457,076.00
Summary
Bowel cancer is one of the most common cancers affecting Australians. We hypothesise that there are different types of bowel cancer depending on different genes that can be inactivated abnormally, and these subgroups have different clinical features and responses to therapy. We aim to identify the major gene changes that characterise these subgroups, which will in the future allow the development of gene markers for early detection as well as the possibility of individualised patient therapy.
The prevalence of liver cirrhosis worldwide is rising due. The majority of the morbidity and mortality, which arises with cirrhosis, occurs due to the development of portal hypertension. In cirrhosis unexplained vasodilatation of the splanchnic circulation occurs contributing significantly to portal hypertension. I expect to confirm through my experiments that the ACE2/Ang 1-7/Mas axis (alternate RAS) is responsible for this vasodilatation and that antagonists targeting this system may have a ro ....The prevalence of liver cirrhosis worldwide is rising due. The majority of the morbidity and mortality, which arises with cirrhosis, occurs due to the development of portal hypertension. In cirrhosis unexplained vasodilatation of the splanchnic circulation occurs contributing significantly to portal hypertension. I expect to confirm through my experiments that the ACE2/Ang 1-7/Mas axis (alternate RAS) is responsible for this vasodilatation and that antagonists targeting this system may have a role in therapy.Read moreRead less
Wnt And MAPK Signalling In The Determination Of Colorectal Neoplasia Pathway
Funder
National Health and Medical Research Council
Funding Amount
$397,179.00
Summary
Polyps are growths in the bowel that may progress to become a bowel cancer. To prevent the development of cancer, these polyps must be removed by timely colonoscopy. There are many different types of bowel polyps, and these are associated with distinct genetic changes and likelihood of recurrence. This study aims to better understand the DNA changes that occur in bowel polyps and how these impact the clinical features of the polyps. In the future this will aid detection and surveillance strategi ....Polyps are growths in the bowel that may progress to become a bowel cancer. To prevent the development of cancer, these polyps must be removed by timely colonoscopy. There are many different types of bowel polyps, and these are associated with distinct genetic changes and likelihood of recurrence. This study aims to better understand the DNA changes that occur in bowel polyps and how these impact the clinical features of the polyps. In the future this will aid detection and surveillance strategies.Read moreRead less
The Role Of Angiotensin-(1-7), Angiotensin Converting Enzyme-2 And The Mas Receptor In Liver Fibrosis And The Development And Maintenance Of Portal Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Chronic liver disease is widespread in our community, and is increasing due to fatty liver disease and viral hepatitis. Liver disease leads to permanent liver scarring, liver cancer and other life-threatening complications. This research investigates the role of a hormone system called the renin-angiotensin system in liver disease, and investigated the use of drugs that act on this system for the prevention and treatment of liver scarring and these complications.