Prorenin And The Prorenin Receptor In Diabetic Retinopathy: Involvement Of The Wnt Pathway And Inflammation
Funder
National Health and Medical Research Council
Funding Amount
$580,042.00
Summary
Diabetic retinopathy is the leading cause of blindness in people of working age. The World Health Organization predicts that by 2030 more than 300 million people will have diabetes. Given the prevalence of diabetic retinopathy and the lack of effective treatments, there is an urgent need to identify the factors that contribute to its development. This project will determine the role of components of a hormonal system, prorenin and its receptor, in diabetic retinopathy and whether they are new ta ....Diabetic retinopathy is the leading cause of blindness in people of working age. The World Health Organization predicts that by 2030 more than 300 million people will have diabetes. Given the prevalence of diabetic retinopathy and the lack of effective treatments, there is an urgent need to identify the factors that contribute to its development. This project will determine the role of components of a hormonal system, prorenin and its receptor, in diabetic retinopathy and whether they are new targets for its treatment.Read moreRead less
Tumour cells are often characterized by defects in signaling pathways. One of the most important signaling cascades involved in the development of cancer is the EGFR-Ras-MAPK pathway. EGFR is often overexpressed in breast cancer, leading to enhanced Ras signaling (hyperactive Ras) and cell transformation. The proposed project aims to identify the molecular mechanisms that can downregulate hyperactive Ras and will make a valuable contribution to our understanding of EGFR-Ras related cancers.
Targeting KRAS Mutations In Cancer Using A Novel SiRNA Delivery Technology
Funder
National Health and Medical Research Council
Funding Amount
$498,899.00
Summary
Mutations in a gene called KRAS are found in 20% of human cancers but are impossible to target with existing treatments. RNA interference is a promising new way to target genes previously considered undruggable, but there is no way to deliver the molecules required for RNA interference to tumours. We will evaluate the ability of a new nanotechnology based delivery system (antibody targeted minicells) to deliver RNA interference, thereby selectively targeting of KRAS in tumours while avoiding tox ....Mutations in a gene called KRAS are found in 20% of human cancers but are impossible to target with existing treatments. RNA interference is a promising new way to target genes previously considered undruggable, but there is no way to deliver the molecules required for RNA interference to tumours. We will evaluate the ability of a new nanotechnology based delivery system (antibody targeted minicells) to deliver RNA interference, thereby selectively targeting of KRAS in tumours while avoiding toxicity to normal tissue.Read moreRead less
Evaluating The Link Between The GPR91 Receptor And Renin In The Pathogenesis Of Diabetic Retinopathy
Funder
National Health and Medical Research Council
Funding Amount
$486,824.00
Summary
Diabetic retinopathy is the leading cause of blindness in people of working age. A hormonal system called renin-angiotensin is implicated in the development of diabetic retinopathy, and new evidence indicates that its blockade improves aspects of the disease. This project will examine if succinate/GPR91 mediates the over production of renin and represents an additional target for the treatment of diabetic retinopathy.