Improving Cardiovascular Outcomes Through Better Trials
Funder
National Health and Medical Research Council
Funding Amount
$1,714,215.00
Summary
Randomised trials are the cornerstone of high quality medical practice. There is an urgent need to do more trials but there are major challenges - timely recruitment of participants, inclusion of representative patients and control of costs are issues we face every day. I will commence a series of new trials evaluating interventions for cardiovascular disease. In parallel I will develop and test innovative solutions to the practicalities of doing large-scale studies.
A Phase III Randomised Placebo-controlled Trial Of Mirtazapine As A Pharmacotherapy For Methamphetamine (Ice) Dependence
Funder
National Health and Medical Research Council
Funding Amount
$3,923,009.00
Summary
Crystalline methamphetamine ('ice') is a growing concern in Australia. There are no approved medications that can be used to treat dependence on this drug. This clinical trial will examine whether mirtazapine, a newly identified treatment agent for methamphetamine use, can be used safely and effectively in routine clinical care to manage methamphetamine dependence in Australia.
Overcoming The Barriers To Treatment Of Multi-drug Resistant Gram-negative Bloodstream Infections In Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$447,603.00
Summary
There is a critical need to develop new treatments for children with antibiotic resistant infections. The most important bacteria causing resistant infections are known as Gram-negative bacteria. Doctors treating children with resistant Gram-negative infections are faced with few antibiotic options. This project will discover the most important resistant infections in Australian children, and trial a new antibiotic to help doctors to use it in the right children and at the right dose.
Creating Treatment Options For Endometrial Cancer Through High-level Clinical Trials
Funder
National Health and Medical Research Council
Funding Amount
$2,508,156.00
Summary
Endometrial cancer (EC) arises from the inner lining of the womb. Treatment typically involves surgery (hysterectomy) to remove the womb and explore if cancer has affected the lymph glands in the pelvis. The benefit of surgery on the lymph glands is doubtful. My research program will generate evidence to inform clinical practice on the treatment of EC and explore non-surgical treatment alternatives to a hysterectomy for better patient outcomes, particularly in women who wish to start a family.