A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Role Of STAT5 In Defining Lifespan In Mouse Models
Funder
National Health and Medical Research Council
Funding Amount
$547,216.00
Summary
We seek to elucidate the molecular basis for the extended lifespan seen in the Methuselah mouse, the longest lived mouse model of ageing. This mouse lacks the receptor for growth hormone, and we have identified a major gene-regulating protein activated by the growth hormone receptor as correlating with lifespan. This project seeks to establish if this protein does indeed regulate lifespan, and to determine how it does this, particularly in relation to metabolism of toxins and free radicals.