Unlocking Hidden Cancer Drivers Using Transcriptome Data
Funder
National Health and Medical Research Council
Funding Amount
$700,473.00
Summary
New sequencing technologies allow us to get an unbiased look at the molecular signalling in a tumour. However this information is very complex and need specialised methods in statistic and computation in order to make new discoveries. Here will will develop analysis methods to find novel transcriptional variants in cancer and then test them in the lab in order to understand if our discoveries are responsible for causing cancer.
A Novel Molecular Mechanism Controlling Myelopoiesis
Funder
National Health and Medical Research Council
Funding Amount
$878,439.00
Summary
The immune system is comprised of many different cell types, each with a specialised function. Many are short-lived and must be continually replenished throughout life. Abnormalities in this process underlie many human diseases, including immunodeficiency, autoimmunity and cancer. We have discovered a novel molecular mechanism that is critical for the production of immune cells. This project will investigate how this mechanism is controlled and the impacts on myelodysplastic syndromes.
Understanding The Contribution Of SRNAs To Antibiotic Resistance In Staphylococcus Aureus
Funder
National Health and Medical Research Council
Funding Amount
$587,424.00
Summary
Golden Staph is a major problem in Australian hospitals. This project will use cutting edge technology to investigate how Golden Staph responds to and resists antibiotics used to treat human infections, leading to new strategies for the prevention and treatment of antibiotic resistant bacteria.
MicroRNA Pathway Control Of Immune Cell Development
Funder
National Health and Medical Research Council
Funding Amount
$631,370.00
Summary
The immune system is comprised of many different cell types, each with a specialised function. Many are short-lived and must be continually replenished throughout life. Abnormalities in this process underlie many human diseases, including immunodeficiency, autoimmunity and cancer. My laboratory seeks to understand the molecular pathways that control development of immune cells and to identify the defects that lead to disease.
A Stem Cell-specific MicroRNA-independent Function Of Drosha
Funder
National Health and Medical Research Council
Funding Amount
$637,702.00
Summary
Stem cells are responsible for producing and replenishing the ~200 specialised cell types in our body. Our goal is to understand the molecular switches that control the function of these cells. We recently discovered that the activity of certain genes within stem cells is controlled by degradation. This degradation is absolutely crucial for safeguarding the function of stem cells. This project will investigate how this novel mechanism is controlled within these cells.
A Multi-Scale Approach To Reliability And Durability Of Engineering Structures And Sensors. The Longford explosion is an example where a major failure was due to a very small defect. It is estimated to have cost Australia in excess of $1.5 Billion. The acquisition costs of aircraft mean that keeping a fleet operational for a year can produce savings of ~$100,000,000.The automotive industry is designing lighter vehicles. GM Australia has realised that ensuring the durability of these new designs ....A Multi-Scale Approach To Reliability And Durability Of Engineering Structures And Sensors. The Longford explosion is an example where a major failure was due to a very small defect. It is estimated to have cost Australia in excess of $1.5 Billion. The acquisition costs of aircraft mean that keeping a fleet operational for a year can produce savings of ~$100,000,000.The automotive industry is designing lighter vehicles. GM Australia has realised that ensuring the durability of these new designs is essential. By our participation in the GM PACE program we ensure that the developments are available to the broader Australian Industry. Indeed, to design durable MEM's structures would give Australia a commercial edge.Read moreRead less
Are some languages better than others? It is important for the Australian community - speaking several hundred different indigenous and immigrant languages across the nation - to realise that each language has approximately (but not precisely) the same overall complexity as every other. One may have intricate word structure, while another has short words but elaborate rules for putting words together to make sentences. And, striding above 'political correctness', many people in Australia will be ....Are some languages better than others? It is important for the Australian community - speaking several hundred different indigenous and immigrant languages across the nation - to realise that each language has approximately (but not precisely) the same overall complexity as every other. One may have intricate word structure, while another has short words but elaborate rules for putting words together to make sentences. And, striding above 'political correctness', many people in Australia will be interested to know whether a certain language is a little more efficient than certain other languages for a particular purpose (for example, commercial business). Read moreRead less
Basic Linguistic Theory. The project is to write the first comprehensive monograph on basic linguistic theory, the theoretical model which underpins almost all grammatical descriptions and most work on typological universals of language (e.g. asking whether all languages have relative clauses, and how these differ between languages). Part 1 will focus on methodology, modes of argumentation and the components of a linguistic description, while Part 2 will profile grammatical categories and const ....Basic Linguistic Theory. The project is to write the first comprehensive monograph on basic linguistic theory, the theoretical model which underpins almost all grammatical descriptions and most work on typological universals of language (e.g. asking whether all languages have relative clauses, and how these differ between languages). Part 1 will focus on methodology, modes of argumentation and the components of a linguistic description, while Part 2 will profile grammatical categories and construction types (such as negation, interrogatives, causatives). This work will constitute both a major contribution to linguistic theory and also a practical manual for pursuing linguistic description and typological generalisations concerning the nature of human language.Read moreRead less