Development of Advanced Fracture Mechanics Models and Novel Technical Tools for Integrity, Durability and Safety Assessment. The proposed project will lead to the new understanding of fracture phenomena and structural integrity. It will create a range of novel computer based technical tools for life and integrity assessment of structures in the presence of cracks and other defects, so as to meet the high safety standards across a wide range of industries. The project will result in technology th ....Development of Advanced Fracture Mechanics Models and Novel Technical Tools for Integrity, Durability and Safety Assessment. The proposed project will lead to the new understanding of fracture phenomena and structural integrity. It will create a range of novel computer based technical tools for life and integrity assessment of structures in the presence of cracks and other defects, so as to meet the high safety standards across a wide range of industries. The project will result in technology that will help to make Australian products stronger and more durable so they become more competitive with low cost overseas imports. All the research outcomes will have a direct benefit to Australian interests, including both public and private industries.Read moreRead less
About one in eight known genetic disorders involve DNA alteration that activates a cellular quality control mechanism that disables the affected gene. This mechanism is more efficient in some individuals than others. It can influence disease outcomes and severity. We will engineer and apply tools and models to measure and manipulate this crucial cellular mechanism. This will allow us to predict disease severity as well as to intervene where a manipulation of this mechanism will be beneficial.
XML Views of Relational Databases: Semantics and Update Problems. XML is the standard for representing, publishing and exchanging data over the Internet and relational database is the dominant technology for data management. Updating XML views over relational data is fundamental to bring these two technologies together to serve Internet-based applications. Australia has been a leading country in both developing and applying internet technologies. The theoretic outcomes of this project will contr ....XML Views of Relational Databases: Semantics and Update Problems. XML is the standard for representing, publishing and exchanging data over the Internet and relational database is the dominant technology for data management. Updating XML views over relational data is fundamental to bring these two technologies together to serve Internet-based applications. Australia has been a leading country in both developing and applying internet technologies. The theoretic outcomes of this project will contribute to the advance in database and web research communities and establish us as an internationally leading group in this research area. The technological outcomes will help organisations in Australia effectively and efficiently conduct e-Business on the Internet. Read moreRead less
Characterising Novel Alternative Splicing Networks That Promote Tumour Cell Plasticity
Funder
National Health and Medical Research Council
Funding Amount
$609,329.00
Summary
During cancer progression, tumour cells can change their properties and become more aggressive and resistant to therapies. We have identified an important regulator of this tumour cell transition, called “Quaking”, which causes widespread changes in gene splicing. We aim to investigate how "Quaking" causes changes in gene splicing and what the effects of these splicing changes are in tumour cells.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560673
Funder
Australian Research Council
Funding Amount
$377,178.00
Summary
Scanning 3D laser vibrometer for non-contact in-plane and out-of-plane vibration measurement. The requested 3D scanning laser vibrometer is intended for the characterisation of 3D vibration of small and large, simple and complex structures, for the purpose of understanding the vibratory behaviour as a precursor to optimising noise and vibration control strategies. It has application to small items for which the use of contact sensors is impossible or impractical, as well as large structures for ....Scanning 3D laser vibrometer for non-contact in-plane and out-of-plane vibration measurement. The requested 3D scanning laser vibrometer is intended for the characterisation of 3D vibration of small and large, simple and complex structures, for the purpose of understanding the vibratory behaviour as a precursor to optimising noise and vibration control strategies. It has application to small items for which the use of contact sensors is impossible or impractical, as well as large structures for which the vibration fields can be complex and a 3D scanning capability is essential. Examples include micro-positioning actuators, piezo-electric motors, live cell response, disk brakes, aircraft and vehicles. Outcomes include the enhancement of existing research projects, allowing a greater understanding of the noise and vibration phenomena.Read moreRead less
Constraints in XML Schema Integration. This project will produce worldwide leading technologies for designing XML data integration system. With the technologies, the well designed integration systems will be able store data with rich semantics and thus provide accurate and understandable information to users. In this way, Australia and communities will be benefited both financially and informatively. The research of this project will also add to the research reputation of Australia in data integ ....Constraints in XML Schema Integration. This project will produce worldwide leading technologies for designing XML data integration system. With the technologies, the well designed integration systems will be able store data with rich semantics and thus provide accurate and understandable information to users. In this way, Australia and communities will be benefited both financially and informatively. The research of this project will also add to the research reputation of Australia in data integration areas. At the same time, the knowledge capacity of Australia on data integration will be enlarged which further improves frontier research activities in the area. Through the research of the project, PhD students will be trained.Read moreRead less
The Role Of UPF3B And Nonsense Mediated MRNA Decay Surveillance In The Pathology Of Intellectual Disability.
Funder
National Health and Medical Research Council
Funding Amount
$789,954.00
Summary
Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundam ....Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundamental importance.Read moreRead less
RNS Hardware for Public-Key Cryptography and E-security. In a world where electronic communication is ever-present, the security of electronic information, e-security, is an issue of the utmost concern for government, business and individuals alike. Public-key cryptography is a powerful tool in the e-security toolkit. Using this technology it is possible to confirm the identity of individuals, maintain the privacy of personal data and guarantee the authenticity of transactions.
The aim of this ....RNS Hardware for Public-Key Cryptography and E-security. In a world where electronic communication is ever-present, the security of electronic information, e-security, is an issue of the utmost concern for government, business and individuals alike. Public-key cryptography is a powerful tool in the e-security toolkit. Using this technology it is possible to confirm the identity of individuals, maintain the privacy of personal data and guarantee the authenticity of transactions.
The aim of this project is to design new public-key cryptography hardware to provide faster, more secure communications for computers, networks and smart cards. Achieving this will require innovations in the way computers perform arithmetic and how this arithmetic is realised as an integrated circuit.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100082
Funder
Australian Research Council
Funding Amount
$500,000.00
Summary
An Australasian facility for the automated fabrication of high performance bespoke components. A facility for the automated fabrication of high performance bespoke components: The project will create a new coordinated facility for composites research including modern automated infrastructure. The facility will bring Australia in line with leading international research centres and promote fundamental and applied research into a range of fields including underwater renewable energy systems, space ....An Australasian facility for the automated fabrication of high performance bespoke components. A facility for the automated fabrication of high performance bespoke components: The project will create a new coordinated facility for composites research including modern automated infrastructure. The facility will bring Australia in line with leading international research centres and promote fundamental and applied research into a range of fields including underwater renewable energy systems, space vehicle structures, multifunctional and smart materials and infrastructure capacity extension. The facility will position Australian research for significant international collaboration through endorsement of next-generation manufacturing technology and enable leading outcomes for Australasian science and engineering in aerospace, marine, civil, automotive, renewable energy and primary resources.Read moreRead less
Flash Point in the Third Sector: A longitudinal follow up study of the clergy care 'battle' within The Salvation Army. Increasing community demands for social support from clergy, along with organisational pressures is thought to underlie the repeated observation that clergy work is highly stressful. The Salvation Army specifically is alarmed by current low retention and recruitment rates.
This innovative longitudinal study of clergy well-being and productivity uses a participatory action re ....Flash Point in the Third Sector: A longitudinal follow up study of the clergy care 'battle' within The Salvation Army. Increasing community demands for social support from clergy, along with organisational pressures is thought to underlie the repeated observation that clergy work is highly stressful. The Salvation Army specifically is alarmed by current low retention and recruitment rates.
This innovative longitudinal study of clergy well-being and productivity uses a participatory action research design to follow-up army officers over a one year period, during which time one-third will be required to relocate to various Australian states in accord with their vocation. Findings will be important for increasing awareness and implications for clergy care in both The Salvation Army and clergy universally.
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