Exploring The Function Of Breast Cancer-Associated Variants In Long Non-Coding RNAs
Funder
National Health and Medical Research Council
Funding Amount
$501,585.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel a ....Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel avenues for therapy.Read moreRead less
Gene Expression Profiling In Critically Ill Patients With Septic Shock: The ADRENAL-GEPS Study
Funder
National Health and Medical Research Council
Funding Amount
$863,304.00
Summary
Sepsis refers to a whole body inflammation caused by severe infection. Approximately one in three adults admitted with septic shock die within 28 days and it is unclear whether treatment with anti-inflammatory drugs is beneficial in terms of patient survival. The aim of this study is to develop a clinical test based on gene activity that can be used to predict patient survival and also determine what the best treatment might be for individual patients.
Identifying Novel Long-noncoding RNAs Involved In The Development Of Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$785,204.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. The aim of this proposal is to identify and characterise these non-coding genes that are modulate breast cancer risk. Understanding how sequences variations that alter these novel genes contribute to breast cancer will provide novel avenues for therapy.
Recently discovered rare manuscripts of mediaeval Pali subcommentaries: a missing link in Buddhist textual transmission. The project will "enhance Australia's capacity to interpret and engage with its regional environment through a greater understanding of languages, societies and cultures" (Research priority 4: Understanding our region and the world); it will deepen our understanding of religious and cultural traditions of many Buddhist countries, which constitute a substantial part of Australi ....Recently discovered rare manuscripts of mediaeval Pali subcommentaries: a missing link in Buddhist textual transmission. The project will "enhance Australia's capacity to interpret and engage with its regional environment through a greater understanding of languages, societies and cultures" (Research priority 4: Understanding our region and the world); it will deepen our understanding of religious and cultural traditions of many Buddhist countries, which constitute a substantial part of Australia's regional environment, and advance our knowledge of Buddhism, the fastest growing religion in Australia. Since this is the first project of its kind in the field of Pali studies, it will increase the international prestige of Australian research capability and open new possibilities for international cooperation in the field.Read moreRead less
FPGA Controller Architectures for Safety Critical Applications. The project industry partner, Invensys Rail Systems, has a major design group in Australia, who work with railway signalling systems throughout the world. Invensys are keen to adopt new technologies to more efficiently and effectively implement signalling functions. However, the safety-critical nature of railway signalling means that any new technology must be analysed in detail to bring it to an acceptable technical readiness lev ....FPGA Controller Architectures for Safety Critical Applications. The project industry partner, Invensys Rail Systems, has a major design group in Australia, who work with railway signalling systems throughout the world. Invensys are keen to adopt new technologies to more efficiently and effectively implement signalling functions. However, the safety-critical nature of railway signalling means that any new technology must be analysed in detail to bring it to an acceptable technical readiness level. The outcomes of this research will be an improved technical readiness level for FPGAs in signalling systems, and this will allow Invensys' Australian design group to develop new technologies and allow them to compete more effectively in the global marketplace.Read moreRead less
Are some languages better than others? It is important for the Australian community - speaking several hundred different indigenous and immigrant languages across the nation - to realise that each language has approximately (but not precisely) the same overall complexity as every other. One may have intricate word structure, while another has short words but elaborate rules for putting words together to make sentences. And, striding above 'political correctness', many people in Australia will be ....Are some languages better than others? It is important for the Australian community - speaking several hundred different indigenous and immigrant languages across the nation - to realise that each language has approximately (but not precisely) the same overall complexity as every other. One may have intricate word structure, while another has short words but elaborate rules for putting words together to make sentences. And, striding above 'political correctness', many people in Australia will be interested to know whether a certain language is a little more efficient than certain other languages for a particular purpose (for example, commercial business). Read moreRead less
Fluid-thermal-structural interactions on high-speed aerospace vehicles. Sixteen years after the retirement of Concorde, high-speed commercial flight is once again on the rise with the development of new supersonic business jets and small airliners as well as hypersonic transport and reusable space launch systems. Robust and efficient designs for these light-weight vehicles must address the problem of aerodynamic heating and its effect on structural performance and lifing. This project will desig ....Fluid-thermal-structural interactions on high-speed aerospace vehicles. Sixteen years after the retirement of Concorde, high-speed commercial flight is once again on the rise with the development of new supersonic business jets and small airliners as well as hypersonic transport and reusable space launch systems. Robust and efficient designs for these light-weight vehicles must address the problem of aerodynamic heating and its effect on structural performance and lifing. This project will design and perform first-of-kind experiments that reproduce the complex fluid-thermal-structural interactions representative of those experienced by these aircraft and rockets. We will then use these measurements to assess, validate and improve the current state-of-the-art of simulation and modelling approaches for design.Read moreRead less
Onset Theory: Pushing the design envelope for textile composite structures. This study aims to exploit an innovative physics-based approach to predict the strength of textile composites. This is particularly important in areas such as aircraft design, where drastic weight savings are needed to allow designers to remain competitive in a low-carbon future. Improved theory and design tools will remove conservatism and account for a large part of these weight savings. The new approach is the first t ....Onset Theory: Pushing the design envelope for textile composite structures. This study aims to exploit an innovative physics-based approach to predict the strength of textile composites. This is particularly important in areas such as aircraft design, where drastic weight savings are needed to allow designers to remain competitive in a low-carbon future. Improved theory and design tools will remove conservatism and account for a large part of these weight savings. The new approach is the first to be consistent at all length scales — from atoms to aeroplanes — ensuring relevance for new and evolving composite material systems. A novel understanding of crack initiation in textile laminates is intended to reduce design and certification effort for new aircraft and help to design more efficient airframes at a lower cost.Read moreRead less
The Papacy in Late Antiquity. The papacy, one of the oldest and most powerful institutions in the world, has recently been revitalized and gives every sign of retaining its authority in the immediate future. The research aims to explain how, across some three hundred years, it came to enjoy its position. In a world in which religious authority and allegiance is becoming more important, locally and internationally, a sound understanding of the foundations of a key institution will be of great ben ....The Papacy in Late Antiquity. The papacy, one of the oldest and most powerful institutions in the world, has recently been revitalized and gives every sign of retaining its authority in the immediate future. The research aims to explain how, across some three hundred years, it came to enjoy its position. In a world in which religious authority and allegiance is becoming more important, locally and internationally, a sound understanding of the foundations of a key institution will be of great benefit. Read moreRead less