Structural And Functional Studies On RNA Nuclear Retention Mediated By Paraspeckles: A Novel Gene Regulation
Funder
National Health and Medical Research Council
Funding Amount
$290,978.00
Summary
Dynamic interactions between proteins and nucleic acids are essential process in gene regulation, where aberrant regulation leads to various diseases including cancers. The project aims to examine the interactions between paraspeckle proteins and nucleic acid molecules via determination of the structures of protein-nucleic acid complexes at the atomic level. The results will provide a better understanding of a recently discovered gene regulation mechanism and a basis for new gene therapy.
A hybrid approach to predict the structure-borne noise transmission in ship structures using a waveguide method and Statistical Energy Analysis. The prediction of structure-borne noise transmission in large welded ship structures is required, in order to design maritime vessels with greater ship power and reduced weight, without increasing the noise levels. The aim of this project is to develop a hybrid approach for structural dynamic analyses using an analytical waveguide method and Statistical ....A hybrid approach to predict the structure-borne noise transmission in ship structures using a waveguide method and Statistical Energy Analysis. The prediction of structure-borne noise transmission in large welded ship structures is required, in order to design maritime vessels with greater ship power and reduced weight, without increasing the noise levels. The aim of this project is to develop a hybrid approach for structural dynamic analyses using an analytical waveguide method and Statistical Energy Analysis. The theoretical estimation and associated experimental measurement of the SEA parameters (modal density, coupling and internal loss factors) form the basis for the hybrid approach. The outcomes will result in improved predictive techniques for dynamic analyses of large complex resonant structures.Read moreRead less
Understanding The Role Of RAS Mutations In Thyroid Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$463,854.00
Summary
My fellowship will examine the association of RAS mutations in thyroid cancer. RAS proteins are the most mutated in cancer and I will investigate how they work in thyroid cancer. RAS mutated thyroid cancer is more likely to cause death. This grant will be based in the pioneering lab of Prof Fagin at Memorial Sloan Kettering Cancer Center and the Garvan Institute of Medical Research. It is hoped by understanding these mutations, new treatments for thyroid cancer can be developed.
Structural and multidisciplinary optimization. Structural and multidisciplinary design optimization is an important subject in aeronautical, aerospace, automobile, offshore platforms and many other structures. This project aims to address design optimization of coupled structures, with a focus on electro-mechanical coupled structures. It is expected to coordinate an integrated effort to develop efficient and effective algorithms for optimum design of electro-mechanical coupled structures.
Shape adaptive structures with built-in compact smart material based actuators. Primary Australian aerospace manufacturers are sub-contractors and constantly compete in the global market. Their products are primarily control surfaces, e.g., Boeing 757 and 777 rudders, 737 Krueger flaps. In light of the development of the hingeless control surfaces (HCS) in the smart aircraft wing program in the USA, the economic benefits of this project are very high because (a) it will address the key technolo ....Shape adaptive structures with built-in compact smart material based actuators. Primary Australian aerospace manufacturers are sub-contractors and constantly compete in the global market. Their products are primarily control surfaces, e.g., Boeing 757 and 777 rudders, 737 Krueger flaps. In light of the development of the hingeless control surfaces (HCS) in the smart aircraft wing program in the USA, the economic benefits of this project are very high because (a) it will address the key technological issue identified in the HCS program; and (b) it will enhance Australian manufacturers¡¯ technological standing and input in the design and manufacturing of next generation HCS by providing highly trained people with world-leading niche technology.Read moreRead less
Active shape control of large thin-walled structures using ferroelectric single crystals. Ferroelectric single crystals were invented 5 years ago, and they possess many superior properties compared to conventional piezoelectric materials, particularly the induced strain up to 1.5%, an order higher than conventional materials. This project aims to poineer the application of these new and powerful smart materials as actuators and sensors to shape control of smart structures. The expected outcome ....Active shape control of large thin-walled structures using ferroelectric single crystals. Ferroelectric single crystals were invented 5 years ago, and they possess many superior properties compared to conventional piezoelectric materials, particularly the induced strain up to 1.5%, an order higher than conventional materials. This project aims to poineer the application of these new and powerful smart materials as actuators and sensors to shape control of smart structures. The expected outcomes are (a) a new constitutive theory for the non-linear behaviour of ferroelectric single crystals; (b) a novel definition and formulation for the shape control problem; and (c) an innovative theoretical framework for design optimization of shape control of smart structures using ferroelectric single crystals.Read moreRead less
Morphing flexible structures with lead lanthanum zirconium titanate (PLZT) based optical actuators. Lead lanthanum zirconate titanate (PLZT) materials yield mechanical strains when exposed to near ultraviolet light as a result of combined photovoltaic and converse piezoelectric effects. They offer actuation strain on par with piezoelectric materials and other advantages, such as wireless light-to-mechanical energy transfer, immunity from electrical and magnetic disturbances and fast response wi ....Morphing flexible structures with lead lanthanum zirconium titanate (PLZT) based optical actuators. Lead lanthanum zirconate titanate (PLZT) materials yield mechanical strains when exposed to near ultraviolet light as a result of combined photovoltaic and converse piezoelectric effects. They offer actuation strain on par with piezoelectric materials and other advantages, such as wireless light-to-mechanical energy transfer, immunity from electrical and magnetic disturbances and fast response with the transparent electrode design. This project aims to pioneer the application of PLZT optical actuators in morphing flexible structures leading to development of wireless smart structures technology and opt-electromechanical systems such as medical instruments.Read moreRead less
Development of a Local Spectral Method for the Computations of Thin-Walled Structures. This project will benefit Aust. society by providing a powerful tool for improving the safe and cost effective design of structures under extreme conditions (high frequency vibration, complicating supporting conditions). The method has the potential to be further developed to provide solutions to unsolved problems in acoustic wave transport, short electromagnetic wave propagation etc. The research training of ....Development of a Local Spectral Method for the Computations of Thin-Walled Structures. This project will benefit Aust. society by providing a powerful tool for improving the safe and cost effective design of structures under extreme conditions (high frequency vibration, complicating supporting conditions). The method has the potential to be further developed to provide solutions to unsolved problems in acoustic wave transport, short electromagnetic wave propagation etc. The research training of the project will help to keep Australia to be at the forefront in this research field and the published research findings will promote the reputation of Australian researchers in the field of computational engineering. The international collaboration will be strengthened between the Investigator's team and his colleagues in US. Read moreRead less
Natural Semantic Metalanguage (NSM): formalisation, computation, referential semantics. Meaning is what links language with culture, communication and cognition but strangely enough, most linguists do not regard semantics (the systematic study of meaning) as a central part of their discipline. This project pursues basic research in the leading meaning-based theory of language: the natural semantic metalanguage (NSM) theory, which has been originated and developed primarily in Australia. It aims ....Natural Semantic Metalanguage (NSM): formalisation, computation, referential semantics. Meaning is what links language with culture, communication and cognition but strangely enough, most linguists do not regard semantics (the systematic study of meaning) as a central part of their discipline. This project pursues basic research in the leading meaning-based theory of language: the natural semantic metalanguage (NSM) theory, which has been originated and developed primarily in Australia. It aims to make this theory more precise, to work out how it can be used by computers, and to connect it with other, more mathematically inspired approaches to meaning.Read moreRead less