About one in eight known genetic disorders involve DNA alteration that activates a cellular quality control mechanism that disables the affected gene. This mechanism is more efficient in some individuals than others. It can influence disease outcomes and severity. We will engineer and apply tools and models to measure and manipulate this crucial cellular mechanism. This will allow us to predict disease severity as well as to intervene where a manipulation of this mechanism will be beneficial.
Characterising Novel Alternative Splicing Networks That Promote Tumour Cell Plasticity
Funder
National Health and Medical Research Council
Funding Amount
$609,329.00
Summary
During cancer progression, tumour cells can change their properties and become more aggressive and resistant to therapies. We have identified an important regulator of this tumour cell transition, called “Quaking”, which causes widespread changes in gene splicing. We aim to investigate how "Quaking" causes changes in gene splicing and what the effects of these splicing changes are in tumour cells.
The Role Of UPF3B And Nonsense Mediated MRNA Decay Surveillance In The Pathology Of Intellectual Disability.
Funder
National Health and Medical Research Council
Funding Amount
$789,954.00
Summary
Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundam ....Proper functioning of the nonsense mediated mRNA decay (NMD or 'mRNA police') is crucial for any cell to ensure normal development and function. When NMD is compromised the outcome is learning and memory problems, autism or schizophrenia. Under this project we study malfunctioning NMD using stem and neuronal cells derived from patients' skin cells. Some of the affected genes might be considered for therapeutic interventions. NMD is relevant to 1000s of human disorders and as such it is of fundamental importance.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561231
Funder
Australian Research Council
Funding Amount
$671,715.00
Summary
MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools acc ....MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools accessible through the Internet will enable researchers to archive, retrieve and exchange data and software; access distributed MR image databases and the latest MR image analysis tools; schedule analysis tasks on the grid compute engine, the outcomes of which will be visualized by the visualization workstations.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100235
Funder
Australian Research Council
Funding Amount
$280,000.00
Summary
Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure wil ....Accelerating Australia's large scale video surveillance research programmes. The research to be conducted using this infrastructure will bring immense benefits to Australia in terms of increased levels of public safety and in the protection of critical facilities from terrorism and other crimes, by developing better surveillance systems. This will provide both increases in measurable research outputs and opportunities for Australian business to commercialise these systems. The infrastructure will accelerate the pace of surveillance research and development in Australia, enhancing the competitiveness of both Australia's researchers and the businesses that will commercialise these researchers' discoveries.Read moreRead less
Tracking targets in large scale surveillance camera networks. The research is expected to provide a significant boost in the effectiveness of safety and security measures for public facilities and open spaces that are monitored by surveillance cameras. The general public benefits from this through a decreased need for intrusive security measures, and increased deterrence of crime and anti-social behaviour. This capability is in demand worldwide for both public and private camera networks, whose ....Tracking targets in large scale surveillance camera networks. The research is expected to provide a significant boost in the effectiveness of safety and security measures for public facilities and open spaces that are monitored by surveillance cameras. The general public benefits from this through a decreased need for intrusive security measures, and increased deterrence of crime and anti-social behaviour. This capability is in demand worldwide for both public and private camera networks, whose usefulness is currently limited by the difficulty of monitoring them. We therefore anticipate considerable commercial interest in Australia and internationally.
Read moreRead less
Image search for simulator content creation. The World Wide Web contains tens of billions of images, with personal and industrial collections stretching to may times that number. The potential economic value of these image-based resources is enormous, but largely untapped as we have no practical way of recovering the images we need. This project will develop image search technologies which will allow Australian industry to exploit these important resources. Some of the wide variety of possible ....Image search for simulator content creation. The World Wide Web contains tens of billions of images, with personal and industrial collections stretching to may times that number. The potential economic value of these image-based resources is enormous, but largely untapped as we have no practical way of recovering the images we need. This project will develop image search technologies which will allow Australian industry to exploit these important resources. Some of the wide variety of possible applications might include the searching of surveillance video for objects of interest, vision-based guidance of unmanned vehicles, smart-phone and smart-home systems which understand their environments, and stock tracking systems which can detect spoilage.Read moreRead less
Deep visual understanding: learning to see in an unruly world. Deep Learning has achieved incredible success at an astonishing variety of Computer Vision tasks recently. This project aims to convey this success into the challenging domain of high-level image-based reasoning. It will extend deep learning to achieve flexible semantic reasoning about the content of images based on information gleaned from the huge volumes of data available on the Internet. The project expects to overcome one of the ....Deep visual understanding: learning to see in an unruly world. Deep Learning has achieved incredible success at an astonishing variety of Computer Vision tasks recently. This project aims to convey this success into the challenging domain of high-level image-based reasoning. It will extend deep learning to achieve flexible semantic reasoning about the content of images based on information gleaned from the huge volumes of data available on the Internet. The project expects to overcome one of the primary limitations of deep learning and will greatly increase its practical application to a range of industrial, cultural or health settings.Read moreRead less
Added depth: automated high level image interpretation. Humans are very good at understanding the world through imagery, but computers lack this fundamental capacity because they lack experience of what they might see. This project will provide this experience by combining the large volumes of imagery on the Internet with three dimensional information generated by humans for other purposes.
Discovery Early Career Researcher Award - Grant ID: DE190100539
Funder
Australian Research Council
Funding Amount
$408,000.00
Summary
Towards conversational vision-based Artificial Intelligence. This project aims to develop a novel learning framework, Vision-Ask-Answer-Act (V3A). This framework will allow a machine to perform a sequence of actions via a conversation with human users, based on intricate processing of not just visual input, but human-computer verbal exchanges. Artificial intelligence has great potential as a tool for economic productivity and daily tasks. Applications in cars and assistant robots, still in their ....Towards conversational vision-based Artificial Intelligence. This project aims to develop a novel learning framework, Vision-Ask-Answer-Act (V3A). This framework will allow a machine to perform a sequence of actions via a conversation with human users, based on intricate processing of not just visual input, but human-computer verbal exchanges. Artificial intelligence has great potential as a tool for economic productivity and daily tasks. Applications in cars and assistant robots, still in their early days, typically require significant expertise to use effectively. The outcomes of this project will push the boundary of vision-language research to produce a conversational intelligent agent that can be easily used in common situations across industry, transport, the medical sector, and at home.Read moreRead less