Exploring The Function Of Breast Cancer-Associated Variants In Long Non-Coding RNAs
Funder
National Health and Medical Research Council
Funding Amount
$501,585.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel a ....Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known protein coding genes, suggesting that non-protein coding genes could be responsible for the associated risk. The aim of this proposal is to identify and characterise these non-coding genes. Understanding how sequences variations in these novel genes contribute to breast cancer will provide novel avenues for therapy.Read moreRead less
Gene Expression Profiling In Critically Ill Patients With Septic Shock: The ADRENAL-GEPS Study
Funder
National Health and Medical Research Council
Funding Amount
$863,304.00
Summary
Sepsis refers to a whole body inflammation caused by severe infection. Approximately one in three adults admitted with septic shock die within 28 days and it is unclear whether treatment with anti-inflammatory drugs is beneficial in terms of patient survival. The aim of this study is to develop a clinical test based on gene activity that can be used to predict patient survival and also determine what the best treatment might be for individual patients.
Identifying Novel Long-noncoding RNAs Involved In The Development Of Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$785,204.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. The aim of this proposal is to identify and characterise these non-coding genes that are modulate breast cancer risk. Understanding how sequences variations that alter these novel genes contribute to breast cancer will provide novel avenues for therapy.
Enhanced Multilingual Speaker Recognition through the Incorporation of High-Level Features, Late Fusion and Discriminative Classification Methods. The development of robust multilingual speaker recognition systems will benefit the community through the elimination of fraud incurred by financial institutions and customers by enabling several person authentication applications such as: voice based signatures and document issuance; credit card verification by voice and secure over-the-phone financi ....Enhanced Multilingual Speaker Recognition through the Incorporation of High-Level Features, Late Fusion and Discriminative Classification Methods. The development of robust multilingual speaker recognition systems will benefit the community through the elimination of fraud incurred by financial institutions and customers by enabling several person authentication applications such as: voice based signatures and document issuance; credit card verification by voice and secure over-the-phone financial transactions. The technology will also assist in the protection of the community and safeguard Australia by enabling the implementation of the following: suspect identification using voice print; national security measures for combating terrorism by using voice to locate and track terrorists; preemptive criminal activity counter-measures; surveillance and secure building access by voice.Read moreRead less
Robust speaker recognition with reduced utterance duration and intersession variability. The development of robust and accurate speaker recognition systems will enable secure person authentication in over-the-phone financial transactions and benefit the community through the elimination of identity fraud incurred by customers and financial institutions. The technology will also assist in safeguarding Australia by enabling the implementation of suspect identification using voice and security meas ....Robust speaker recognition with reduced utterance duration and intersession variability. The development of robust and accurate speaker recognition systems will enable secure person authentication in over-the-phone financial transactions and benefit the community through the elimination of identity fraud incurred by customers and financial institutions. The technology will also assist in safeguarding Australia by enabling the implementation of suspect identification using voice and security measures for combating terrorism by using voice to locate and track terrorists. Our research at QUT Speech Research Lab is at the forefront of development in this field and will provide Australia with a technological advantage in the rapidly evolving global market for speaker recognition technology for person authentication applications.Read moreRead less
Robust Automatic Speaker Diarisation of Audio Documents by Exploiting Prior Sources of Information. Speaker Diarisation, the task of determining who spoke when, is a technology fundamental in deriving intelligent information from audio and multimedia resources. The requirement for efficient and accurate Speaker Diarisation systems, portable across different domains is heightened by the explosive growth of audio and multimedia archives online and throughout the world. This research will provide t ....Robust Automatic Speaker Diarisation of Audio Documents by Exploiting Prior Sources of Information. Speaker Diarisation, the task of determining who spoke when, is a technology fundamental in deriving intelligent information from audio and multimedia resources. The requirement for efficient and accurate Speaker Diarisation systems, portable across different domains is heightened by the explosive growth of audio and multimedia archives online and throughout the world. This research will provide the foundation for a commercial service of automatic Speaker Diarisation to be developed, growing Australia's impact on the information and communications technology (ICT) sector. The outcome of this research will also assist in the tracking of terrorist and unlawful activity by enabling effective intelligence gathering from different audio sources.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0561231
Funder
Australian Research Council
Funding Amount
$671,715.00
Summary
MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools acc ....MRI GRID Computing Facility: Design, Optimisation and Image Processing. The MRI Grid Computing Facility provides the IT infrastructure to achieve effective e-research in the area of magnetic resonance (MR) imaging, a field of neuroscience research that revolutionizes the way brain diseases are identified and treated. The facility consists of a dedicated high performance grid compute engine, distributed visualisation workstations, and distributed data warehouse facilities. Software tools accessible through the Internet will enable researchers to archive, retrieve and exchange data and software; access distributed MR image databases and the latest MR image analysis tools; schedule analysis tasks on the grid compute engine, the outcomes of which will be visualized by the visualization workstations.Read moreRead less
Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament ....Automatic cartilage segmentation in magnetic resonance imaging. Osteoarthritis (OA) is the most common form of arthritis, affecting nearly 1.4 million Australians. This research aims at engineering new tools for use in Magnetic Resonance Imaging systems to enable automated analyses of the cartilage and bones in joint images. The goals of the work are to assist with improved diagnosis and treatment planning for both chronic disease, such as OA, and acute injuries, such as cartilage and ligament tears in sporting injuries and other traumas.
The software developed will be provided on the project’s partner (Siemens) platform and will therefore be available worldwide and have a consequently large impact on the field.
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Techniques to use stereo vision for improving person identification systems based on face recognition. The broad aim of this project is to use three-dimensional information available by processing images from stereo cameras in order to bridge the gap between constrained face recognition systems and viable systems that work well under varying illumination, changes in pose and variations in spectacles, facial hair and attire. Such a system will be useful in passenger verification at airports and a ....Techniques to use stereo vision for improving person identification systems based on face recognition. The broad aim of this project is to use three-dimensional information available by processing images from stereo cameras in order to bridge the gap between constrained face recognition systems and viable systems that work well under varying illumination, changes in pose and variations in spectacles, facial hair and attire. Such a system will be useful in passenger verification at airports and as a component of personal identification systems to counter terrorism. The key to successful face location and recognition is an effective combination of all data - range, luminance and colour - and techniques for this will be the discovered outcomes.Read moreRead less
Non-viral Vectors For Targeted Delivery Of RNAi Nucleotides To Cervical Cancers
Funder
National Health and Medical Research Council
Funding Amount
$415,738.00
Summary
RNA interference (or gene silencing) is a new technique whereby we are able to turn off the expression of a particular gene either temporarily or permanently. Cancer is basically a genetic disease where certain protective genes are lost or cancer-causing genes expressed. Gene silencing holds great promise in the treatment of genetic disorders, infectious diseases and cancer. Cervical cancer is caused by infection with the human papillomavirus and the expression of two cancer-causing genes. Using ....RNA interference (or gene silencing) is a new technique whereby we are able to turn off the expression of a particular gene either temporarily or permanently. Cancer is basically a genetic disease where certain protective genes are lost or cancer-causing genes expressed. Gene silencing holds great promise in the treatment of genetic disorders, infectious diseases and cancer. Cervical cancer is caused by infection with the human papillomavirus and the expression of two cancer-causing genes. Using RNA interference we can turn off the expression of these two genes which results in the death of the cancer cell. We are also able to cure mice of tumours derived from human cervical cancer. The major issue with gene silencing is how to deliver it effectively to patients. Here we are investigating novel nanoparticulate systems to deliver this new gene-inhibiting drugs preferentially to the tumour site.Read moreRead less