Defining Early Epigenetic Causes Of Cardiac Hypertrophy And Failure
Funder
National Health and Medical Research Council
Funding Amount
$620,917.00
Summary
A big heart is bad news, no matter what the cause. Sometimes this happens when the heart is under stress. At other times no cause can be found. These studies will identify the molecular switches and signals that can transform a normal heart into a big heart. Some of these are inherited, some activated by stress. Armed with knowledge of the molecular mechanisms we can identify those at risk and design new targets for novel treatment strategies.
Mechanisms Responsible For Neurogenic Hypertension: Role Of A Novel Interaction Between Amygdala-hypothalamic GABA Pathways And The MicroRNA Regulation Of Renin
Funder
National Health and Medical Research Council
Funding Amount
$576,538.00
Summary
We identified that mice bred to have high blood pressure (hypertension) have an overactive nervous system due to a faulty molecule in a small region of the brain that controls emotion and the response to stress. The high nervous activity affects a hormone in the kidney that may lead to hypertension. The proposal will determine the mechanisms and neurochemicals in the brain that are responsible for magnifying the responses to stress leading to hypertension and test a new therapy to treat high blo ....We identified that mice bred to have high blood pressure (hypertension) have an overactive nervous system due to a faulty molecule in a small region of the brain that controls emotion and the response to stress. The high nervous activity affects a hormone in the kidney that may lead to hypertension. The proposal will determine the mechanisms and neurochemicals in the brain that are responsible for magnifying the responses to stress leading to hypertension and test a new therapy to treat high blood pressure.Read moreRead less
Mechanism Of Epidermal Growth Factor Receptor Transactivation
Funder
National Health and Medical Research Council
Funding Amount
$578,268.00
Summary
This application examines the cellular events that control heart growth in response to angiotensin, a hormone linked to heart failure. We believe that the same cell processes are also involved in cancer cell growth and by understanding the mechanism by which angiotensin promotes growth, better therapies against human cardiovascular disease and its relationship to uncontrolled growth will evolve.
CCR4/NOT Complex Is A Conserved Regulator Of Heart Function
Funder
National Health and Medical Research Council
Funding Amount
$467,567.00
Summary
Cardiovascular diseases kill an Australian every 11 minutes. The goal of this proposal is to characterize the role of the conserved heart regulators in cardiac function and disease. Our combined multi-species and informatics approach has identified a major disease locus for sudden cardiac death in humans, which we propose to characterize. This work can lead to new classes of drugs to improve cardiac health and also aid in early diagnosis of patients susceptible to sudden cardiac death.