Identification Of Novel ERBB2 Co-operating Tumor Suppressors Using In Vivo RNAi Screens.
Funder
National Health and Medical Research Council
Summary
Invasive breast cancer is often lethal, however, noninvasive disease has a >98% survival rate. Thus, understanding how breast cancer develops invasive ability is an important research goal. Using a new method in mice predisposed to breast cancer, we will find genes that prevent tumor invasion and determine if they are important in human cancer. By understanding how these genes restrict tumor invasion, we hope to develop therapies to improve breast cancer treatment.