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Reducing Household Air Pollution Exposure To Improve Early Child Health And Development; Extending The Intervention And Follow-up Of Poriborton: The CHANge Trial.
Funder
National Health and Medical Research Council
Funding Amount
$2,916,420.00
Summary
Around the world each year household air pollution causes 4.3 million deaths. Mothers, babies and children, who spend the most time at home are extremely vulnerable. We will study the health of infants who have had reduced exposure in their first critical years of life and compare them to infants whose exposure was not reduced. This will provide compelling evidence for governments around the world of the need to assist families in developing settings to adopt clean energy.
Cancers can spread to the lung causing fluid build-up and requires drainages in hospital that are painful and costly. Surgery is previously seen as the definitive option to stop fluid forming, but is invasive with complications. Indwelling pleural catheter (IPC) is a novel implanted device inside the chest that allows patients to drain fluid at home. AMPLE Trial-3 is the first multicenter randomized clinical trial to compare surgery vs IPC to provide fluid control and improve quality of life.
Breathing Control As A Treatment For Non-Epileptic Seizures
Funder
National Health and Medical Research Council
Funding Amount
$1,740,186.00
Summary
Non-epileptic Seizures (NES) are fits that look like epilepsy but are not, and are instead thought to be a psychological response to problems. Treating them psychologically is difficult, however, and doesn't usually work. We have discovered that patients' fits involve hyperventilation, like a panic attack, and can be stopped by teaching them to control their breathing in a similar way. In this study we aim to prove this, by completing a trial of breath control training in NES.
This clinical trial will test whether a combination of two safe therapies, abatacept and nasal insulin, can stop the immune attack that causes type 1 diabetes. Sixty-two children and young adults with recently-diagnosed type 1 diabetes will receive either abatacept and nasal insulin or abatacept and nasal placebo for one year to determine if combined immune therapy preserves pancreas function and decreases the need for insulin therapy.