Roadblocks To DNA Replication And Implications For Antimicrobial Resistance
Funder
National Health and Medical Research Council
Funding Amount
$1,050,000.00
Summary
Antimicrobial drugs have revolutionised modern medicine in their ability to specifically target microbial infections. However, overuse of these drugs is resulting in more and more infectious microbes becoming resistant to them. This program aims to use molecular imaging techniques to visualise how microbes respond to antimicrobials and how they evolve to become resistant. The outcomes of this program will enable the identification of drug targets and the development of diagnostics.
Axonal Regeneration And Degeneration: Cellular And Molecular Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$2,088,220.00
Summary
The ability to surgically repair an injured axon and restore neuronal function is still a significant challenge in neurosurgery. However, a spontaneous repair mechanism, axonal fusion, by which the two separated ends of a transected axon are fused back together, has been observed in invertebrates. Understanding the molecular mechanisms of this biological event will allow us to determine its potential as a novel therapeutic approach to repair injured and damaged neurons.