Fragment based screening to deliver drugs targeting tuberculosis and the gametocyte and liver stages of Plasmodium. This project will identify natural products that bind to critical proteins in malaria and tuberculosis to discover new ways to treat these diseases.
Australian Laureate Fellowships - Grant ID: FL230100104
Funder
Australian Research Council
Funding Amount
$3,400,000.00
Summary
Bringing Equality Home: A New Gender Agenda. Compared to other countries, Australia has slipped backwards in achieving gender equality and is in danger of falling further behind. This jeopardises opportunities for all Australians and undermines social cohesion and economic progress. This project aims to provide the theoretical and empirical foundations to reverse this trend. The expected outcomes will be a new theory of gender inequality, a new approach that foregrounds the explanatory importanc ....Bringing Equality Home: A New Gender Agenda. Compared to other countries, Australia has slipped backwards in achieving gender equality and is in danger of falling further behind. This jeopardises opportunities for all Australians and undermines social cohesion and economic progress. This project aims to provide the theoretical and empirical foundations to reverse this trend. The expected outcomes will be a new theory of gender inequality, a new approach that foregrounds the explanatory importance of caregiving and domestic work and new insights into the life course stages where gender inequality is most malleable. This will provide significant benefits including the impetus for new research, policy initiatives and capacity to build a more equal, stronger and prosperous Australia.Read moreRead less
How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. ....How parents manage climate anxiety: coping and hoping for the whole family. This project studies how Australian parents manage climate anxiety for themselves and their families. Using mixed-methods/mixed-media approaches, it examines whether an increase in climate disasters is accelerating the spread of collective anxiety amongst families, how parents manage this anxiety for their children and partners, and if there are associated mental health burdens and gendered inequities in this management. It also looks at climate anxiety management across generations and climate histories, drawing out pessimistic/optimistic narratives about the future to enable action, resilience, and hope. It will produce an evidence base and photo-voice/documentary resources to help parents and support organisations combat climate anxiety.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100071
Funder
Australian Research Council
Funding Amount
$290,000.00
Summary
Chemi–biology computational platform for lead discovery in infectious disease. A challenge in fighting infectious disease is in finding new bioactive compounds. This facility will provide a high performance computational environment designed to accelerate the discovery of quality compounds for use in anti-infective medicine.
Glycan-based prebiotic approaches to increase food safety in Australia. Since the launch of the first Australian Animal Sector National Antimicrobial Resistance Plan (2018) several approaches have been suggested to reduce the use antibiotics in agriculture, however no alternatives to antibiotics have been suggested or trialled. In this proposal we aim to develop a novel glycan-based prebiotic strategy to reduce Campylobacter jejuni colonisation in chicken and poultry by disrupting important glyc ....Glycan-based prebiotic approaches to increase food safety in Australia. Since the launch of the first Australian Animal Sector National Antimicrobial Resistance Plan (2018) several approaches have been suggested to reduce the use antibiotics in agriculture, however no alternatives to antibiotics have been suggested or trialled. In this proposal we aim to develop a novel glycan-based prebiotic strategy to reduce Campylobacter jejuni colonisation in chicken and poultry by disrupting important glycan-glycan interactions. Outcomes of this proposal is a cost-effective antibiotic- and vaccine-independent animal feed supplement strategy that will decrease the risk of human food-borne illness and therefore promoting food safety and public health in Australia. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100226
Funder
Australian Research Council
Funding Amount
$424,000.00
Summary
Advanced molecular discovery and characterisation facility. Natural product drug discovery in Australia requires access to high throughput functional assays to guide the separation and of novel bioactives with therapeutic potential. By establishing the advanced molecular discovery and characterisation facility in an academic environment across two institutions, research programs in early drug lead discovery and characterisation will be accelerated. It will provide unique capabilities not curren ....Advanced molecular discovery and characterisation facility. Natural product drug discovery in Australia requires access to high throughput functional assays to guide the separation and of novel bioactives with therapeutic potential. By establishing the advanced molecular discovery and characterisation facility in an academic environment across two institutions, research programs in early drug lead discovery and characterisation will be accelerated. It will provide unique capabilities not currently available in Australia, and help Australian researchers remain internationally competitive in breakthrough science and frontier technologies. The research enabled by this facility will lead to development of new drug candidates by the emerging Australian biotechnology industry.Read moreRead less