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Plasma Exchange And Glucocorticoids In Anti-neutrophil Cytoplasm Antibody Associated Systemic Vasculitis: A Randomised Controlled Trial (PEXIVAS Australia)
Funder
National Health and Medical Research Council
Funding Amount
$420,110.00
Summary
ANCA-associated vasculitis is a life-threatening disease. The PEXIVAS trial will investigate whether plasma exchange, in addition to immunosuppressive therapy and glucocorticoids, will reduce death and the development of severe kidney failure due to this disease. Additionally, the project will also look at whether using a reduced dose of glucocorticoids is just as effective as larger doses in lessening the infectious complications of treatment.
The Beta-blocker To LOwer CArdiovascular Dialysis Events (BLOCADE) Feasibility Study
Funder
National Health and Medical Research Council
Funding Amount
$597,811.00
Summary
The BLOCADE Feasibility Study aims to find out what is needed for a study to see if the drug carvedilol reduces heart disease events in people who need kidney dialysis. Carvedilol is widely used to treat the types of heart disease that are common in people on dialysis but the nature of dialysis may lead to more side effects or to less benefit. A Feasibility Study must be done first to properly plan a large study of carvedilol in people on dialysis that answers this important question.
Canadian-Australasian Randomised Trial Of Screening Kidney Transplant Recipients For Coronary Artery Disease (CARSK Study)
Funder
National Health and Medical Research Council
Funding Amount
$1,223,933.00
Summary
Patients waitlisted for kidney transplantation are at increased risk of heart attack and routinely undergo tests every year to screen for heart disease. This may lead to excessive tests, inconvenience, cost and missed opportunities for transplantation. This randomised trial will determine whether such testing is necessary and what it costs to patients and the health system. The results will have implications for tens of thousands of patients worldwide.