Neurodevelopmental Outcome After Sevoflurane Versus Dexmedetomidine/remifentanil Anaesthesia In Infancy: A Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$825,787.00
Summary
Evidence in animals show that some anaesthetics affect the developing brain. Some human data also show a link between childhood surgery and poorer neurodevelopmental outcome. It is unknown if this association is due to the anaesthetic. Our recent GAS trial showed no evidence for toxicity after 1 hour of anaesthesic but many children have longer anaesthetics. We plan to enrol 420 infants in a study comparing neurodevelopmental outcome after 2 different anaesthetics for surgery lasting >2 hours ....Evidence in animals show that some anaesthetics affect the developing brain. Some human data also show a link between childhood surgery and poorer neurodevelopmental outcome. It is unknown if this association is due to the anaesthetic. Our recent GAS trial showed no evidence for toxicity after 1 hour of anaesthesic but many children have longer anaesthetics. We plan to enrol 420 infants in a study comparing neurodevelopmental outcome after 2 different anaesthetics for surgery lasting >2 hours.Read moreRead less
The Influence Of Anaesthetic Depth On Patient Outcome After Major Surgery
Funder
National Health and Medical Research Council
Funding Amount
$2,893,795.00
Summary
Millions of high-risk patients have general anaesthesia for major surgery worldwide every year, but the optimal depth of anaesthesia for these patients is not known. The aim of this large randomised trial is to determine the impact of light versus deep general anaesthesia on survival at one year postoperatively in 6,500 older patients. If light anaesthesia is associated with better survival, this result will be immediately implementable, will save lives and will reduce the costs of care.
Outcomes From A Multi-site Randomised Controlled Trial Comparing Regional And General Anaesthesia For Effects On Neurodevelopmental Outcome And Apnoea In Infants
Funder
National Health and Medical Research Council
Funding Amount
$757,831.00
Summary
Animal studies suggest general anaesthetics harm the developing brain. It is unclear if these findings are relevant to humans. The aim of this international randomised controlled trial is to determine whether children exposed to general anaesthesia as an infant have a poorer neurodevelopmental outcome. A previous NHMRC grant funded the first phase of the trial along with substantial funding from overseas. The trial will tell us if general anaesthetics affect the developing brain in children.