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Large-scale Randomised Evidence: The Reliable Detection Or Refutation Of Treatment Effects Through Large, Simple Randomised Trials And Collaborative Meta-analyses Of Trials Using Individual Participant Data
Funder
National Health and Medical Research Council
Funding Amount
$425,897.00
Summary
Randomised controlled trials are the most reliable scientific method of studying medical treatments. Well-designed trials are thus needed to confidently guide doctors, other health professionals and policy-makers, particularly for common conditions such as cardiovascular disease. This Fellowship will study how we can better prevent and treat cardiovascular disease through the design, conduct and analysis of such trials at the University of Oxford, a world-leader in randomised controlled trials.
Moving Research Into Practice – Using Process Evaluations Of Treatment Mechanisms To Inform The Implementation Of Evidence-based Healthcare
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
Effective treatments must be integrated into clinical practice. But this process isn’t always efficient. One reason for this is a lack of understanding for how treatments work. My research will identify treatment mechanisms for chronic back pain (leading cause of disability world-wide) and use this information to integrate effective reatments into practice. I will work with experts from the Oxford Clinical Trials Unit, UK and apply this research to clinical health service units in Australia.
Understanding The Association Between Low Back Pain And Risk Factors For Chronic Disease
Funder
National Health and Medical Research Council
Funding Amount
$314,644.00
Summary
Being overweight or obese and smoking are believed to be significant contributors to the development of long term back pain. However we know little about the relationship between low back pain and these risks for chronic disease. This research aims to understand these relationships by testing if weight and smoking programs reduce low back pain disability in overweight or smoking patients, and secondly if back pain also influences risk factors for chronic disease.
Towards Global Control Of Scabies: Advances In Diagnosis, Treatment And Community Control
Funder
National Health and Medical Research Council
Funding Amount
$340,891.00
Summary
The scabies mite causes severe itch and rash and leads to infections, kidney and heart disease. Scabies affects up to 50% of children in Indigenous communities. We now know most scabies can be prevented, so we urgently need to find the most effective strategies. My research will develop new tests to help doctors to accurately diagnose scabies. I will test new medicines to treat scabies and strategies to prevent scabies and its complications in children, families and entire populations.
Psychoeducational Program To Address Women’s Genital Appearance Concerns
Funder
National Health and Medical Research Council
Funding Amount
$191,261.00
Summary
An increasing number of women are seeking to alter the appearance of their genitals through unproven cosmetic surgery. There are no options besides surgery for women concerned about their genitals. I propose to develop and evaluate an online psychological program which aims to assist these women. If found to be effective, the program could be used throughout Australia and internationally, potentially reducing the total number of women undergoing genital cosmetic surgery.
Improving Outcomes Of Severe Bacterial Infections In Northern Australia
Funder
National Health and Medical Research Council
Funding Amount
$217,274.00
Summary
Severe infections such as pneumonia can cause failure of vital organs (severe sepsis) and subsequent death. 30-40% of people who develop severe sepsis die, even with the best modern therapies. Sepsis is five times more common in northern Australia than elsewhere. In this program of research, we plan to test new therapies for sepsis; to determine the causes of and risk factors for severe pneumonia in northern Australia; and to use this information to inform new guidelines for the management of se ....Severe infections such as pneumonia can cause failure of vital organs (severe sepsis) and subsequent death. 30-40% of people who develop severe sepsis die, even with the best modern therapies. Sepsis is five times more common in northern Australia than elsewhere. In this program of research, we plan to test new therapies for sepsis; to determine the causes of and risk factors for severe pneumonia in northern Australia; and to use this information to inform new guidelines for the management of sepsis and pneumonia in northern Australia.Read moreRead less
Simple Cognitive Behavioural Treatment Of The Symptoms Of Trauma In First Episode Psychosis
Funder
National Health and Medical Research Council
Funding Amount
$173,898.00
Summary
Psychotic disorders (such as schizophrenia) are some of the most severe forms for mental disorder. Many people with psychosis have experienced trauma in childhood or as a result of their psychosis, and have developed post-traumatic stress disorder as a result. The aim of the proposed study is to test whether a simple psychological intervention is effective in reducing trauma symptoms in FEP. This has the potential to significantly improve outcomes in FEP.
Skill Building Interventions To Address Barriers To Social Inclusion For People With Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$251,715.00
Summary
People with a psychotic illness often experience unemployment, social isolation and difficulty living independently. Social and cognitive (e.g. thinking and memory) skill difficulties contribute to this, however, most psychiatric treatments fail to improve the underlying skill problems. This program of research will measure whether computer-assisted cognitive remediation and social skill training can effectively improve everyday living and social participation in people with a psychotic illness.
A Randomised Trial Of Allowing Men Who Have Sex With Men To Have HIV And Syphilis Tests Between Clinic Consultations.
Funder
National Health and Medical Research Council
Funding Amount
$381,414.00
Summary
Rates of HIV and syphilis are rising in gay men in Australia. If these men have HIV and syphilis blood tests more frequently this is likely to reduce the spread of these infections. This trial tests the hypothesis that increased access to testing will increase the rate of testing. We are comparing the rate of testing in 420 gay men, half of whom are allowed to test whenever they choose, without having another clinical consultation.
Studies of pregnant women are essential for determining new ways to improve the health of women and their infants. Information collected in these studies can answer many valuable questions, but only if used in the right way. This project will develop new statistical methods to make the most of information collected in these studies so that we can understand the true effects of a treatment and hence accurate health advice can be given to pregnant women.