High Penetrance Deleterious Mutations In Blinding Glaucoma
Funder
National Health and Medical Research Council
Funding Amount
$1,345,055.00
Summary
This project aims to identify the genes most commonly mutated in individuals with advanced glaucoma. Identification of such genes will lead to improved understanding of glaucoma pathogenesis, a better ability to predict risk, and the identification of drug targets for novel therapies.
Effects Of Latrepirdine On Beta Amyloid Clearance, Aggregation And Neurodegeneration In Alzheimer�s Disease
Funder
National Health and Medical Research Council
Funding Amount
$512,647.00
Summary
Alzheimer's disease (AD) is becoming more common with our growing aged population and currently no treatment exists that halts disease progress. The increasing health costs of AD underscore the need for development of any treatment that will slow or halt AD pathogenesis. By understanding the mechanisms of action of a drug [latrepirdine] that has recently shown some promise in phase II clinical trials, related drugs that are more specific and potent will be developed.
The Effect Of Selected Nutraceuticals On Brain Blood Vessels And Memory.
Funder
National Health and Medical Research Council
Funding Amount
$445,206.00
Summary
The human brain receives 1000L of blood per day, distributed through minute vessels called capillaries. The integrity and function of brain capillaries is compromised with aging and this may contribute to memory disturbances. Our laboratory has identified several naturally occurring compounds that prevent age-associated defects of brain capillaries. The primary aim of this project is to explore if these agents are beneficial for restoring brain capillary function and memory.
Judgment, responsibility, and the life-world: The phenomenological critique of formalism. This project will contribute to building Australia's capacity in the area of phenomenology and connecting Australian researchers into the international network of phenomenology research. More generally the project will contribute to the broader community debate that is currently emerging around issues of the role and limits of knowledge, especially scientific knowledge, but also knowledge as it arises and i ....Judgment, responsibility, and the life-world: The phenomenological critique of formalism. This project will contribute to building Australia's capacity in the area of phenomenology and connecting Australian researchers into the international network of phenomenology research. More generally the project will contribute to the broader community debate that is currently emerging around issues of the role and limits of knowledge, especially scientific knowledge, but also knowledge as it arises and is applied in organisational and social contexts, and the importance of responsibility and judgment even in areas of technical problem-solving and decision-making. In this latter respect, the project is likely to have an impact in more directly applied areas such as policy formation and decision-making across many different areas.Read moreRead less
Gender and the Production of Early Modern French Medicine. This project contributes to a long-term, large-scale research endeavour focused on the interaction of gender and the development of forms of science and technology in history. This project constitutes a significant investigation into the gendering of medical theory and practice. It is an innovative survey of early modern ideas about the production of medical knowledge and practices, about who had the right and authority to determine medi ....Gender and the Production of Early Modern French Medicine. This project contributes to a long-term, large-scale research endeavour focused on the interaction of gender and the development of forms of science and technology in history. This project constitutes a significant investigation into the gendering of medical theory and practice. It is an innovative survey of early modern ideas about the production of medical knowledge and practices, about who had the right and authority to determine medical theory and about how women participated in this framework. The project is expected to result in a major research monograph and a number of key articles.
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Reduction of risk in exploration for petroleum liquids. Australia has an urgent need to establish additional reserves of crude oil. A feature of petroleum exploration in recent decades has been discovery of vast reserves of natural gas but an inability to replace our diminishing reserves of crude oil. Clearly new technology is required to enhance our capability to recognise crude oil-prone rather than gas-prone source rocks. The proposed project will establish the fundamental geochemical pro ....Reduction of risk in exploration for petroleum liquids. Australia has an urgent need to establish additional reserves of crude oil. A feature of petroleum exploration in recent decades has been discovery of vast reserves of natural gas but an inability to replace our diminishing reserves of crude oil. Clearly new technology is required to enhance our capability to recognise crude oil-prone rather than gas-prone source rocks. The proposed project will establish the fundamental geochemical processes that will support the potential exploration techniques, developed with Woodside Energy Limited support.Read moreRead less
Productive Pedagogies, Productive Schools and Gender Reform. This proposal seeks to document policy developments at federal, state and school systems in relation to boys' schooling and measure their effectiveness within a gender equity framework. It also seeks to document and evaluate the effectiveness of school structural and pedagogical reforms geared to better meeting the educational needs of boys without detracting from the education of girls. Finally, the study will map pedagogies and analy ....Productive Pedagogies, Productive Schools and Gender Reform. This proposal seeks to document policy developments at federal, state and school systems in relation to boys' schooling and measure their effectiveness within a gender equity framework. It also seeks to document and evaluate the effectiveness of school structural and pedagogical reforms geared to better meeting the educational needs of boys without detracting from the education of girls. Finally, the study will map pedagogies and analyse their effectiveness against such factors as the gender of the teacher and gender composition of classes, and subject domains, across both primary and secondary schools.Read moreRead less
Psychosomatic Illness in Early Modern Italy: lessons for modern psychiatric theory and practice. This pioneering collaboration between researchers in humanities and medicine will investigate the ways psychosomatic illness was defined and spread in early modern Italy. Epidemics of such illness still occur today and have had a major social and economic impact on Australia in recent decades. Our project will draw lessons for modern psychiatric theory and practice from historical and cultural differ ....Psychosomatic Illness in Early Modern Italy: lessons for modern psychiatric theory and practice. This pioneering collaboration between researchers in humanities and medicine will investigate the ways psychosomatic illness was defined and spread in early modern Italy. Epidemics of such illness still occur today and have had a major social and economic impact on Australia in recent decades. Our project will draw lessons for modern psychiatric theory and practice from historical and cultural differences in the conceptualisation and communication of 'hypochondria'. It will shed light on a very contemporary ethical dilemma in psychiatry: should doctors lie to 'hypochondriacal' patients? It will also contribute to current debates on the role of disease labels and information in the incidence and 'infectiousness' of psychosomatic illness.Read moreRead less