Control Of The Ras/Erk Signaling Pathway By The Brahma Chromatin-remodeling Complex
Funder
National Health and Medical Research Council
Funding Amount
$524,820.00
Summary
Hormones bind and initiate molecular signals within cells to proliferate or change into specific cell types. This is important for growth and development of different tissues. A pathway which is critical for transmitting the effects of hormones in cells is the Ras pathway. New studies by the applicants indicate that the Brahma complex, a molecule important in controlling the levels of proteins in cells, activates the Ras pathway. This project will define how Brahma controls the Ras pathway.
Understanding The Role Of RAS Mutations In Thyroid Cancer.
Funder
National Health and Medical Research Council
Funding Amount
$463,854.00
Summary
My fellowship will examine the association of RAS mutations in thyroid cancer. RAS proteins are the most mutated in cancer and I will investigate how they work in thyroid cancer. RAS mutated thyroid cancer is more likely to cause death. This grant will be based in the pioneering lab of Prof Fagin at Memorial Sloan Kettering Cancer Center and the Garvan Institute of Medical Research. It is hoped by understanding these mutations, new treatments for thyroid cancer can be developed.
KRAS- And BRAF-Mediated Methylation Signatures In Colorectal Cancers And Polyps
Funder
National Health and Medical Research Council
Funding Amount
$457,076.00
Summary
Bowel cancer is one of the most common cancers affecting Australians. We hypothesise that there are different types of bowel cancer depending on different genes that can be inactivated abnormally, and these subgroups have different clinical features and responses to therapy. We aim to identify the major gene changes that characterise these subgroups, which will in the future allow the development of gene markers for early detection as well as the possibility of individualised patient therapy.
Characterization Of Ras-Stimulated Macropinocytosis In Pancreatic Cancer
Funder
National Health and Medical Research Council
Funding Amount
$470,964.00
Summary
Pancreatic cancer (PC) is one of the most lethal human cancers, namely due to frequent late stage diagnosis. Thus, there is urgent need to better understand the biology of this disease. Cancer cells are characteristically more reliant on nutrients in order to sustain their growth, making them more vulnerable to inhibition of nutrient supplies. The key aim of this project is to better understand the ways in which PC cells take up nutrients so that these processes may potentially be blocked.
Targeting KRAS Mutations In Cancer Using A Novel SiRNA Delivery Technology
Funder
National Health and Medical Research Council
Funding Amount
$498,899.00
Summary
Mutations in a gene called KRAS are found in 20% of human cancers but are impossible to target with existing treatments. RNA interference is a promising new way to target genes previously considered undruggable, but there is no way to deliver the molecules required for RNA interference to tumours. We will evaluate the ability of a new nanotechnology based delivery system (antibody targeted minicells) to deliver RNA interference, thereby selectively targeting of KRAS in tumours while avoiding tox ....Mutations in a gene called KRAS are found in 20% of human cancers but are impossible to target with existing treatments. RNA interference is a promising new way to target genes previously considered undruggable, but there is no way to deliver the molecules required for RNA interference to tumours. We will evaluate the ability of a new nanotechnology based delivery system (antibody targeted minicells) to deliver RNA interference, thereby selectively targeting of KRAS in tumours while avoiding toxicity to normal tissue.Read moreRead less
Wnt And MAPK Signalling In The Determination Of Colorectal Neoplasia Pathway
Funder
National Health and Medical Research Council
Funding Amount
$397,179.00
Summary
Polyps are growths in the bowel that may progress to become a bowel cancer. To prevent the development of cancer, these polyps must be removed by timely colonoscopy. There are many different types of bowel polyps, and these are associated with distinct genetic changes and likelihood of recurrence. This study aims to better understand the DNA changes that occur in bowel polyps and how these impact the clinical features of the polyps. In the future this will aid detection and surveillance strategi ....Polyps are growths in the bowel that may progress to become a bowel cancer. To prevent the development of cancer, these polyps must be removed by timely colonoscopy. There are many different types of bowel polyps, and these are associated with distinct genetic changes and likelihood of recurrence. This study aims to better understand the DNA changes that occur in bowel polyps and how these impact the clinical features of the polyps. In the future this will aid detection and surveillance strategies.Read moreRead less