The Persisting Vascular Effects Of Activation Of The Renin-Angiotensin System
Funder
National Health and Medical Research Council
Funding Amount
$628,456.00
Summary
Heart attacks and strokes are the major cause of death and disability in Australians. Heart disease is widely viewed to be the legacy of our diet and lifestyle, and even that of our parents. We propose to explore in detail the molecular mechanism of how this imprinting comes about and identify new targets to prevent, retard or reverse heart disease.
Modulating Pathogenic Signalling Towards The Prevention Of Diabetic Complications
Funder
National Health and Medical Research Council
Funding Amount
$622,655.00
Summary
Diabetes is associated with an increased risk of heart attacks and kidney failure. There remains an urgent need for new targets and therapies for preventing, arresting, treating and reversing these diabetic complications. My research directly focuses on identifying and validating these targets treatments, building on strong preliminary data and understanding of the molecular mechanisms set off by high sugar levels.
Interactions Between RAGE And The Type 1 Angiotensin Receptor Determine The Pro-atherosclerotic Actions Of Angiotensin II
Funder
National Health and Medical Research Council
Funding Amount
$521,956.00
Summary
Heart attacks and strokes are a major cause of death and disability in Australians. Activation of the renin angiotensin system plays a key role in the development and progression of atherosclerosis, the process that leads to narrowing and obstruction of arteries. In preliminary data we have found a way to block these pathways without affecting the control of blood pressure. We believe that interventions based on these data will be important for the prevention and treatment of heart disease.
RAGE And ACE2 Shedding As Therapeutic Targets In Diabetes And Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$748,447.00
Summary
We have previously demonstrated the pivotal role of two shed proteins, Receptor for Advanced Glycation End-products (RAGE) and Angiotensin Converting Enzyme Receptor 2 (ACE2) in heart disease and diabetic complications. In this project, we will use a novel technologies to modify shedding of these proteins from the cell surface and alter their ability to cause disease.
Hybrid cooling for coal fired power stations. Water shortage is a nation wide problem facing Australian industries. The project will directly benefit the Victorian power industry through water saving. If the new proposed hybrid cooling system concept is proved to be practically feasible, it will put the Australian power industry in a strong competitive position in terms of its efficiencies and waste heat recovery technology. Lowering the temperature of water into the cooling tower by 2 degree, b ....Hybrid cooling for coal fired power stations. Water shortage is a nation wide problem facing Australian industries. The project will directly benefit the Victorian power industry through water saving. If the new proposed hybrid cooling system concept is proved to be practically feasible, it will put the Australian power industry in a strong competitive position in terms of its efficiencies and waste heat recovery technology. Lowering the temperature of water into the cooling tower by 2 degree, by using the hybrid cooling system, it would save over 17,500,000 tons of makeup water per year for the Victorian power industry alone. At the same time, the waste heat recovered by the heat pump can be fed back to the power generation cycle. Read moreRead less
Hydro-mechanical interactions in coal geo-sequestration of carbon dioxide. One of the most critical environmental issues facing society is that of global warming because of increasing concentrations of carbon dioxide released from burning of fossil fuels. Storage of CO2 in the ground, geo-sequestration, offers the promise of significant reductions in atmospheric CO2 release, particularly from coal fired power stations which produce 40% of Australia's CO2 emissions. The proposed project will lead ....Hydro-mechanical interactions in coal geo-sequestration of carbon dioxide. One of the most critical environmental issues facing society is that of global warming because of increasing concentrations of carbon dioxide released from burning of fossil fuels. Storage of CO2 in the ground, geo-sequestration, offers the promise of significant reductions in atmospheric CO2 release, particularly from coal fired power stations which produce 40% of Australia's CO2 emissions. The proposed project will lead to greater understanding and reduced risks during the injection and storage of CO2 in deep unmineable coal deposits. This will contribute to national efforts to reduce global warming, safeguard the Australian coal industry, and allow continued electricity generation from coal-fired plants. Read moreRead less
Monitoring and Modelling Hydrogeochemical Interactions with Groundwater : Implications for Mine Dewatering on Groundwater, River and Lake Chemistry. Alcoa operates a power station and brown coal mine at Anglesea in western Victoria. Following heavy rain in 2000 acidic water entered the Anglesea estuary causing precipitation of iron and aluminium flocs and fish kills. Estuary closure to tourism resulted. This project will identify the cause(s) of this phenomenon by modelling groundwater movement ....Monitoring and Modelling Hydrogeochemical Interactions with Groundwater : Implications for Mine Dewatering on Groundwater, River and Lake Chemistry. Alcoa operates a power station and brown coal mine at Anglesea in western Victoria. Following heavy rain in 2000 acidic water entered the Anglesea estuary causing precipitation of iron and aluminium flocs and fish kills. Estuary closure to tourism resulted. This project will identify the cause(s) of this phenomenon by modelling groundwater movement and studying geochemical processes. The resultant hydrogeochemical model will also be applied to simulating longer term water quality changes in the catchment arising from current mine dewatering operations and future rewatering following mine closure.
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Numerical and experimental studies of the gas-particle flow and dust collection in electrostatic precipitation systems. This project will generate an integrated computer model to describe the gas-solid flow and dust collection in an ElectroStatic Precipitator (ESP). The model can be used to aid the design and control of ESP systems which are widely used for dust collection, leading to more competitive energy and related industries.
Synthesis of functionalised metal oxide beads with hierarchical pores for radionuclide and metal sequestration. The central aim of this project is to fabricate nanostructured materials to address the worldwide issue of nuclear waste. These novel materials, with tailored porosity and surface functionality, will decrease both radioactive waste volume and the potential for environmental risk. The collaboration between the Caruso group at the University of Melbourne and the Luca group at ANSTO will ....Synthesis of functionalised metal oxide beads with hierarchical pores for radionuclide and metal sequestration. The central aim of this project is to fabricate nanostructured materials to address the worldwide issue of nuclear waste. These novel materials, with tailored porosity and surface functionality, will decrease both radioactive waste volume and the potential for environmental risk. The collaboration between the Caruso group at the University of Melbourne and the Luca group at ANSTO will educate more scientists and students in the areas of nuclear science and engineering, and the environmental impact of nuclear power generators. Such expertise is currently in high demand around the world, thereby enhancing Australia's position in the global nuclear field.Read moreRead less
An assessment of carbon dioxide storage capacity of water bearing sedimentary basins. Dealing with the problems caused by climate change and global warming is among the greatest challenges facing Australia today. One of the approaches being considered to minimise anthropogenic influence over climate is the geo-sequestration of carbon dioxide (CO2). The proposed project will lead to greater understanding of storage capacity of sedimentary basins and identification of optimum injection conditions ....An assessment of carbon dioxide storage capacity of water bearing sedimentary basins. Dealing with the problems caused by climate change and global warming is among the greatest challenges facing Australia today. One of the approaches being considered to minimise anthropogenic influence over climate is the geo-sequestration of carbon dioxide (CO2). The proposed project will lead to greater understanding of storage capacity of sedimentary basins and identification of optimum injection conditions for geo-sequestration in such aquifers, and any potential mechanisms that could lead to migration of CO2 from the source rock back to the atmosphere.This will contribute to national efforts to reduce global warming, safeguard the Australian economy, and allow continued electricity generation from coal-fired plants.Read moreRead less