A Randomised Controlled Trial Of Exercise Programs For Preventing Knee Injuries
Funder
National Health and Medical Research Council
Funding Amount
$1,160,491.00
Summary
The promotion of physical activity, either through organised sport or active recreation, is a key public health strategy in this country. However, there is a risk of injury during this participation and efforts need to be undertaken to reduce this risk so that spor is safe for all. Sports injury prevention efforts to date in Australia have been severely hampered by a lack of evidence supporting currently advocated countermeasures. This concern has been recognised by both the NHMRC and the Common ....The promotion of physical activity, either through organised sport or active recreation, is a key public health strategy in this country. However, there is a risk of injury during this participation and efforts need to be undertaken to reduce this risk so that spor is safe for all. Sports injury prevention efforts to date in Australia have been severely hampered by a lack of evidence supporting currently advocated countermeasures. This concern has been recognised by both the NHMRC and the Commonwealth Department of Health and Ageing. It is imperative that we formally evaluate the effectiveness of sports injury countermeasures in the context of broad community level participation in sport, in contrast to previous research focussed on professional sport, and begin to deliver the preventive measures to the community. Australian football is a popular sport throughout Australia and it is associated with more medically-treated injuries than any other sport. Knee injuries are particularly common and can have severe consequences. One of the most commonly recommended knee injury prevention strategies is a well-designed exercise training program. Despite their potential to significantly reduce injury rates, the effectiveness of exercise training programs to prevent knee injuries in football, and indeed in most other sports, has not previously been assessed but has been identified as a priority research area by the NHMRC. This project will determine the effectiveness of exercise training programs for preventing knee injuries in community-level football players by monitoring injury rates, player behaviours and player attitudes before and after the training programs are implemented.Read moreRead less
National Centre Of Research Excellence To Improve Management Of Peripheral Arterial Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,618,637.00
Summary
Approximately 15% of adults have blockages or weakness of major arteries in the periphery, associated with impaired quality of life and a high mortality. Significant management deficiencies for these problems include limited diagnostic, prognostic and treatment options, as well as poor adoption of evidence based practice. The proposed national centre will bring together a group of experts in the field to instigate a number of initiatives to improve patient management.
A Phase III Trial Comparing Adjuvant Versus Salvage Radiotherapy For High Risk Patients Post Radical Prostatectomy
Funder
National Health and Medical Research Council
Funding Amount
$819,138.00
Summary
About half of all patients Treated with an operation to remove their prostate cancer have a high chance of the cancer coming back. Giving immediate radiotherapy to all patients will improve cure rates but does not benefit all men and can cause significant side effects. This study explores whether it is safe to wait and only give radiotherapy when there is a rising PSA after surgery indicating active cancer. A total of 470 men from Australasia will enter this study comparing the two approaches.
Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial o ....Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial of a tailored program for kinship carers and expects to generate vital knowledge on evidence-based support. Via implementing an innovative program for kinship carers in statutory child protection, this project should build capacity for research-based practice and benefit family wellbeing and placement outcomes in kinship care.Read moreRead less
Aspirin For The Prevention Of Cognitive Decline In The Elderly: A Neuro-Vascular Imaging Study (ENVIS-ion) From ASPREE
Funder
National Health and Medical Research Council
Funding Amount
$1,341,232.00
Summary
The ENVIS-ion trial will examine whether Aspirin is effective in delaying the onset of worsening of thinking and memory abilities in healthy older adults. Magnetic resonance imaging (MRI) of brain structure will detect markers of early worsening of thinking and memory abilities. Blood vessels in the back of the eye (retina) share many features with vessels in the brain. We will compare whether aspirin lessens changes over time of features shown with brain MRI and retinal photography.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Improving The Prevention, Treatment And Management Of Cardiovascular & Chronic Disease In The Community
Funder
National Health and Medical Research Council
Funding Amount
$774,540.00
Summary
The identification, prevention and management of cardiovascular and chronic disease risk factors and understanding impact on clinical outcomes is fundamental to improving health and well-being. The program of work encapsulated in this application utilises modern epidemiological research methods involving large scale clinical trials, registries and epidemiological modelling to advance our understanding and provide new directions for cardiovascular disease prevention and management.
Centre Of Research Excellence In Cardiovascular Outcomes Improvement
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
Quality, safety and the effectiveness of providing prevention and treatments to those with cardiovascular disease is the focus of research of the CRE in Cardiovascular Outcomes Improvement. Utilizing data derived from clinical registries and large patient databases of patients receiving various treatments for heart problems, we will investigate what factors are important in delivering cost-effective favorable outcomes. The centre will train future leaders in cardiovascular research focusing on
Novel Approaches To The Prevention And Treatment Of Chronic Heart Disease And Its Co-morbid Complications
Funder
National Health and Medical Research Council
Funding Amount
$5,793,580.00
Summary
Cardiovascular disease (CVD) and its associated additional disorders constitute major public health problems, especially given the rapidly ageing population which is increasingly affected by obesity and diabetes. This Program will explore novel therapies for the treatment of CVD and associated diseases, particularly focussing on chronic kidney disease, translating preliminary laboratory-based findings into clinical trials and then clinical and epidemiological findings into practice and policy.
A Randomised Controlled Trial Of Interventional Versus Conservative Treatment Of Primary Spontaneous Pneumothorax
Funder
National Health and Medical Research Council
Funding Amount
$412,315.00
Summary
Primary spontaneous pneumothorax (PSP) is a collapsed lung that occurs in otherwise healthy people without underlying lung disease. Current standard treatment is to insert a chest drain into the chest to remove the air around the collapsed lung so that the lung re-inflates rapidly ("interventional treatment"). We will determine whether doing nothing, i.e. letting the lung re-inflate slowly on its own over several weeks ("conservative treatment"), is just as good or even better for patients.