Mitochondrially targeted anti-cancer drugs modulate the mitochondrial genome. Successful cancer management requires novel therapeutical approaches. This project will test the effect of a new class of compounds that target mitochondria, the powerhouse of the cells, where they suppress expression of mitochondrial genes. By this mechanism, cancers that are resistant to apoptosis induction can be inhibited.
Continuous Reaction Networks that Model Chemical Evolution of RNA. This Project aims to develop experimental models for chemical evolution that may have happened on the early Earth and which were important to the emergence of life. This Project expects to uncover synthetic pathways for ribonucleotide production using a combination of ionizing radiation and dry-wet cycles. Expected outcomes include an increased understanding of the range of physical and chemical parameters that will allow for rib ....Continuous Reaction Networks that Model Chemical Evolution of RNA. This Project aims to develop experimental models for chemical evolution that may have happened on the early Earth and which were important to the emergence of life. This Project expects to uncover synthetic pathways for ribonucleotide production using a combination of ionizing radiation and dry-wet cycles. Expected outcomes include an increased understanding of the range of physical and chemical parameters that will allow for ribonucleotide production to occur under the proposed geochemical settings. The knowledge gained in this Project will benefit the understanding of the chemical evolution of complex chemical mixtures relevant to early Earth environments and provide new mechanisms for how ribonucleotides could have arisen abiotically.Read moreRead less
The Total Column Carbon Observing Network in the Southern Hemisphere: constraining our understanding of the carbon cycle and climate. The global carbon cycle and the distribution, sources and sinks of greenhouse gases such as carbon dioxide and methane are crucial drivers of climate change. The Total Carbon Column Observing Network (TCCON) measures the amounts of greenhouse and other trace gases in the atmosphere by solar remote sensing from the ground with unprecedented accuracy and precision. ....The Total Column Carbon Observing Network in the Southern Hemisphere: constraining our understanding of the carbon cycle and climate. The global carbon cycle and the distribution, sources and sinks of greenhouse gases such as carbon dioxide and methane are crucial drivers of climate change. The Total Carbon Column Observing Network (TCCON) measures the amounts of greenhouse and other trace gases in the atmosphere by solar remote sensing from the ground with unprecedented accuracy and precision. TCCON data are the "gold standard" for total column measurements and an essential part of greenhouse gas science. They are used to improve knowledge of the carbon cycle and future climate change, both directly and by validating global-scale satellite measurements. This project will continue to expand TCCON in the southern hemisphere and the enhanced scientific understanding it will provide.Read moreRead less
Novel platinum(IV) complexes that are targeted to and trapped by tumours and tumour cells. Platinum complexes continue to be a mainstay in the treatment of solid tumours and their combination with molecularly targeted agents selected for the type of tumour and the mutations identified is expected to lead to continued growth in their use. However, their toxicity remains a major impediment to their use and effectiveness and therefore, this project aims to develop less toxic analogues that are as l ....Novel platinum(IV) complexes that are targeted to and trapped by tumours and tumour cells. Platinum complexes continue to be a mainstay in the treatment of solid tumours and their combination with molecularly targeted agents selected for the type of tumour and the mutations identified is expected to lead to continued growth in their use. However, their toxicity remains a major impediment to their use and effectiveness and therefore, this project aims to develop less toxic analogues that are as least as effective as current drugs. This project will combine recent developments in stabilisation and cellular trapping of platinum(IV) pro-drugs with a range of strategies designed to limit activation of these pro-drugs to the tumour environment.Read moreRead less
The Contribution of Tropical Cyclones to the Earth Energy Budget. This project aims to quantify the tropical cyclone contribution to the earth energy budget to understand whether tropical cyclones feed back to the climate system. While existing literature focuses exclusively on the effects of climate change on tropical cyclone variability, this project switches this viewpoint around. One possible outcome is a better understanding of long-term tropical cyclone variability. This is particularly im ....The Contribution of Tropical Cyclones to the Earth Energy Budget. This project aims to quantify the tropical cyclone contribution to the earth energy budget to understand whether tropical cyclones feed back to the climate system. While existing literature focuses exclusively on the effects of climate change on tropical cyclone variability, this project switches this viewpoint around. One possible outcome is a better understanding of long-term tropical cyclone variability. This is particularly important for tropical cyclone vulnerable regions including the Australian east coast and the oil and gas industry off the Northwest Shelf. Furthermore, the anticipated knowledge gained by this project will inform international understanding on the impacts of tropical cyclones to the overall climate system.Read moreRead less