Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to ....Enabling Technologies for Motion Corrected Positron Emission Tomography (PET) of Unanaesthetized Laboratory Animals. Small animal molecular imaging is a powerful tool in biological research and drug discovery. Anaesthesia is routinely used to avoid motion distortion, but can profoundly alter the biological process studied. This research will enable quantitative imaging of neurobiological phenomena in awake laboratory animals. It will create new opportunities for Australian basic researchers to use innovative technology with expected high economic potential, and benefit small biotech companies by facilitating pre-clinical and clinical development of new pharmaceuticals. The new motion tracking and image reconstruction technologies developed will strengthen Australia's leading position in engineering and biomedical systems development.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775747
Funder
Australian Research Council
Funding Amount
$160,000.00
Summary
Distributed Medical Image Analysis and Visualisation Engine (MedVis). Improved understanding of neurological processes is crucial to improving clinical outcomes for patients. MedVis will contribute in three ways: support development of new methods of interpretation and analysis of complex neurological studies, allowing current methods to be applied more efficiently, and enabling distributed simulations and visualisations in real-time from remote sites.
The leading-edge, grid-based, software and ....Distributed Medical Image Analysis and Visualisation Engine (MedVis). Improved understanding of neurological processes is crucial to improving clinical outcomes for patients. MedVis will contribute in three ways: support development of new methods of interpretation and analysis of complex neurological studies, allowing current methods to be applied more efficiently, and enabling distributed simulations and visualisations in real-time from remote sites.
The leading-edge, grid-based, software and computational techniques developed for the project will enable visualization, analysis and modelling of massive volumes of image and other visualisation data. This capability is important in medical research where large visualisation data volumes are being created and studied by experts remote from each other.
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High resolution single particle analysis of biological macromolecules. One of the great challenges of cell biology is to increase the rate of atomic resolution structure determination, particularly of membrane proteins and macromolecular assemblies. The current rate-limiting step is high quality crystal production. Our goal is to prove that protein structures can be determined to atomic resolution by single-particle analysis. 3D structures will be produced by computationally aligning high-resolu ....High resolution single particle analysis of biological macromolecules. One of the great challenges of cell biology is to increase the rate of atomic resolution structure determination, particularly of membrane proteins and macromolecular assemblies. The current rate-limiting step is high quality crystal production. Our goal is to prove that protein structures can be determined to atomic resolution by single-particle analysis. 3D structures will be produced by computationally aligning high-resolution electron microscope images of individual, randomly oriented molecules. The importance of this project is highlighted by the fact over 120,000 protein sequences are already databased, a number set to increase rapidly as new genome sequencing projects are completed.
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Special Research Initiatives - Grant ID: SR0567334
Funder
Australian Research Council
Funding Amount
$125,748.00
Summary
A Grid-Enabled National Archive of Nanostructural Imagery (GRANI). The Nanostructural Analysis Network Organization (NANO) is an Australian Major National Research Facility that provides access to a grid of advanced microscopic instruments for the nanostructural analysis of both physical materials and biological systems. The aim of this initiative is to provide the NANO community with a set of common, interoperable tools and services to enable more efficient, cost-effective storage, management, ....A Grid-Enabled National Archive of Nanostructural Imagery (GRANI). The Nanostructural Analysis Network Organization (NANO) is an Australian Major National Research Facility that provides access to a grid of advanced microscopic instruments for the nanostructural analysis of both physical materials and biological systems. The aim of this initiative is to provide the NANO community with a set of common, interoperable tools and services to enable more efficient, cost-effective storage, management, analysis and sharing of generated microscopic images, video and analytical data. The significance of the proposed middleware is that it will improve collaboration and reduce duplication across many disciplines, through a shareable, distributed national scientific image/video database.Read moreRead less
The Origin and Evolution of Cosmic Magnetism. This research will significantly advance our understanding of structure and evolution in the Universe, in keeping with Australia's outstanding track record of astronomical discovery. This program will also train students and build research capacity in the frontier area of X-ray astronomy, in which Australia currently has limited expertise. The instrumentation and techniques to be developed will lead to innovative transfers of technology to fields su ....The Origin and Evolution of Cosmic Magnetism. This research will significantly advance our understanding of structure and evolution in the Universe, in keeping with Australia's outstanding track record of astronomical discovery. This program will also train students and build research capacity in the frontier area of X-ray astronomy, in which Australia currently has limited expertise. The instrumentation and techniques to be developed will lead to innovative transfers of technology to fields such as telecommunications and medical imaging. These new facilities will also serve as vital stepping stones to the Square Kilometre Array, a billion-dollar international project which promises enormous economic, engineering and scientific opportunities for Australia.Read moreRead less
Exploring the last frontier: cosmic reionization and the first galaxies. This program will help to position Australia as a leader in the development of the Square Kilometre Array, a 1.5 billion Euro radio telescope that Australia is vying to host. The program takes advantage of the uniquely radio quiet environment of Western Australia to achieve unprecedented measurements of the 'first light fossils' in the Universe, which reside in the portion of the radio spectrum that is filled by FM radio tr ....Exploring the last frontier: cosmic reionization and the first galaxies. This program will help to position Australia as a leader in the development of the Square Kilometre Array, a 1.5 billion Euro radio telescope that Australia is vying to host. The program takes advantage of the uniquely radio quiet environment of Western Australia to achieve unprecedented measurements of the 'first light fossils' in the Universe, which reside in the portion of the radio spectrum that is filled by FM radio transmissions in most parts of the planet. This ground-breaking research program will provide training for the next generation of world-class scientists and add to the already high profile of Australian astrophysics.Read moreRead less
International collaboration in gravitational wave data analysis, simulations and third generation detectors. The project brings together seven outstanding international researchers into close collaboration with an Australian team to develop new techniques for finding gravitational wave signals in the vast archive of data they have helped to collect, as well as developing and testing theory for improved detectors that operate with sensitivity beyond the limits set by classical physics. The projec ....International collaboration in gravitational wave data analysis, simulations and third generation detectors. The project brings together seven outstanding international researchers into close collaboration with an Australian team to develop new techniques for finding gravitational wave signals in the vast archive of data they have helped to collect, as well as developing and testing theory for improved detectors that operate with sensitivity beyond the limits set by classical physics. The project will utilize a state of the art supercomputer and the superb national facility for high power laser interferometry at Gingin, Western Australia. Read moreRead less
Low energy all-optical logic gates with improved cascadability and fan-out for future optical communications and signal processing systems. All-optical logic processing is the key to overcoming electronic bottlenecks in high-speed communication networks as single-channel speeds exceed electronic capabilities. This research will build off and extend Australia's world leading specialty fibre and fibre device capabilities and place Australia at the forefront in the international all-optical digital ....Low energy all-optical logic gates with improved cascadability and fan-out for future optical communications and signal processing systems. All-optical logic processing is the key to overcoming electronic bottlenecks in high-speed communication networks as single-channel speeds exceed electronic capabilities. This research will build off and extend Australia's world leading specialty fibre and fibre device capabilities and place Australia at the forefront in the international all-optical digital information-processing race. High quality research publications will enhance Australia's strong research reputation in photonics and advanced materials and promote international collaboration. New optical processing capabilities will benefit other application areas such as sensing and security.Read moreRead less
High-performance computational data-mining techniques for feature detection in complex time series from large-scale, networked plasma experiments. Terabytes of data are gathered from large experimental facilities as complex time-series. Analysis of these data is daunting, especially when they involve high-dimensional spectral or image arrays. We will develop high-performance computational techniques for dimension reduction, efficient data-mining, and experimental control, using as an initial ta ....High-performance computational data-mining techniques for feature detection in complex time series from large-scale, networked plasma experiments. Terabytes of data are gathered from large experimental facilities as complex time-series. Analysis of these data is daunting, especially when they involve high-dimensional spectral or image arrays. We will develop high-performance computational techniques for dimension reduction, efficient data-mining, and experimental control, using as an initial target the H-1NF plasma fusion MNRF at the ANU and its >100 GB/year data stream. The techniques will immediately provide Australian researchers with unique tools for collaboration in international research to develop fusion as a low-emissions source of electricity, and will be applicable to complex time-series analysis in other areas of science, medicine, and defence.Read moreRead less
Nano-Engineered Glass for Next Generation Optical Fibre Devices and Systems. Optical fibre and fibre devices are a major technology platform of the IT revolution. The global photonics market is valued at $220bn, with Australian industry contributing ~$500m to the Australian economy. $158m is from communications photonics companies, largely SMEs, and comprises roughly 1% of the global telecoms photonic market. For Australia to be a significant player in this very competitive environment, the indu ....Nano-Engineered Glass for Next Generation Optical Fibre Devices and Systems. Optical fibre and fibre devices are a major technology platform of the IT revolution. The global photonics market is valued at $220bn, with Australian industry contributing ~$500m to the Australian economy. $158m is from communications photonics companies, largely SMEs, and comprises roughly 1% of the global telecoms photonic market. For Australia to be a significant player in this very competitive environment, the industry needs a continuing flow of research innovations. The breakthrough science in this research project will extend Australia's world leading speciality fibre and fibre device capabilities and the innovation will succour the growing Australian industry, ensuring a place on the next wave of deployment of photonic technology.Read moreRead less